Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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NPS were observed to be highly prevalent in AD patients.
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Global concern on the potential impact of dementia is mounting.
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Recent studies have used non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), to increase dorsolateral prefrontal cortex (DLPFC) activity and, consequently, working memory (WM) performance.
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64/100
This article reviews all papers published since the inception of the initiative and summarizes the results as of February 2011.
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The diagnostic criteria continued to result in rather frequent diagnosis of comorbidity.
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The Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has provided clinical, operational, and data management support to ADNI since its inception.
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The incidence and prevalence in those over age 65 of neurodegenerative disorders and chronic diseases, which often have deleterious effects on cognition, are rapidly increasing in western societies.
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A history of depression may confer an increased risk for later developing AD.
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Diabetes mellitus may be associated with an increased risk of developing AD and may affect cognitive systems differentially.
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Difficulties in the performance of everyday activities were found more frequently in non-demented subjects with mild cognitive deficits than in the general population.
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Of the 204 patients enrolled in the study, re-review after as many as 5 years of follow-up resulted in a final clinical classification of 188 with probable AD.
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A case-control study was performed to determine the possible roles of various environmental factors, prior illnesses, drug use, and personal habits in the development of Alzheimer's disease.
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Agreement for the global CDR was moderate (κ = 0.53, 95% CI: 0.47-0.59).
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Correlations between in-person and T-COG scores were of moderate to large magnitude (Pearson r: 0.57 to 0.80, intraclass correlation coefficients: 0.52 to 0.79).
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A+/High-EA individuals exhibited slower cognitive decline in global cognition and language domains than A+/Low-EA individuals.
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In 320 patients, baseline plasma NfL levels were negatively associated with global cognition (β=-1.28 (-1.81 ; -0.75) P < 0.001), memory (β=-1.48 (-2.38 ; -0.59), P = 0.001), language (β=-1.72(-2.49 ; -0.95) P < 0.001), praxis (β=-2.02 (-2.91 ; -1.13) P < 0.001) and executive functions (β=-0.81, P < 0.001).
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In weighted models, greater loneliness was associated with microinfarcts, lower episodic and working memory in the absence of AD pathology, lower working memory in the absence of infarcts, a stronger association of infarcts with lower episodic memory, and a stronger association of microinfarcts with lower working and semantic memory.
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After adjusting for age, health status, and young adult general cognitive ability, plasma NfL level was only significantly associated with processing speed and white matter hyperintensity (WMH) volume, but not with other cognitive or neuroimaging measures.
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Currently, 1549 participants have been screened, and 815 randomized.
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Multivariable linear regressions showed an association of metabolic syndrome with lower performance in attention (β=1.62 seconds, 95% CI=0.20, 3.04) and memory (β=-0.62 words, 95% CI=-1.19, -0.05) that could be driven by associations with elevated fasting glucose and abdominal obesity.
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This study included 407 participants (96 Thal, 405 Braak, and 406 CERAD).
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63/100
among VRFs-free participants, TC (HR 0.62, 95%CI 0.40-0.95) and LDL-C (HR 0.47, 95%CI 0.28-0.80) were inversely associated with incident dementia, LDL-C was inversely associated with incident AD (HR 0.50, 95%CI 0.28-0.90).
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63/100
Carriers (n = 39) and noncarriers (n = 36) had similar neuropsychological performance, except for lower Letter Digit Substitution Test scores in carriers.
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ObjectivesIdentifying modifiable factors that shape cognitive aging trajectories is a central goal in aging research.
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After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care.
From across this topic
10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes
- Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study
- [Presbyacusis]
- Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
- Reshaping the mind: The benefits of bilingualism
- The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease
- Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing
- Recommendations for optimal ICD codes to study neurologic conditions: a systematic review
- Plasma markers of neurodegeneration, latent cognitive abilities and physical activity in healthy aging
- Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction