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Association between depression, gender and Alzheimer's neuropathology in older adults without dementia
Doyoung Kim, Alex Kiss, Susan E Bronskill, Krista L Lanctôt, Nathan Herrmann, Damien Gallagher. International journal of geriatric psychiatry, 2022-10
Topic: Brain imaging, connectivity and assessment
This study included 407 participants (96 Thal, 405 Braak, and 406 CERAD). Those who had recently active depression (within previous 2 years) but not remote depression only were more likely to have higher Thal phase score compared to those without a history of depression (OR = 3.74; 95% CI, 1.15-12.17; p = 0.028). Sex did not moderate this association. No significant associations between recent depression and Braak or CERAD scores were observed. Our findings indicate that the association between late life depression and Alzheimer's neuropathology is associated with spread of amyloid pathology beyond the neocortex to include allocortical and subcortical regions critical for regulation of mood and motivated behavior.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kim, D., Kiss, A., Bronskill, S. E., Lanctôt, K. L., Herrmann, N., & Gallagher, D. (2022). Association between depression, gender and Alzheimer's neuropathology in older adults without dementia. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.5809
Vancouver
Kim D, Kiss A, Bronskill SE, Lanctôt KL, Herrmann N, Gallagher D. Association between depression, gender and Alzheimer's neuropathology in older adults without dementia. International journal of geriatric psychiatry. 2022. doi:10.1002/gps.5809. PMID: 36047339.
BibTeX
@article{kim2022-36047339,
author = {Kim, Doyoung and Kiss, Alex and Bronskill, Susan E and Lanctôt, Krista L and Herrmann, Nathan and Gallagher, Damien},
title = {{Association between depression, gender and Alzheimer's neuropathology in older adults without dementia}},
journal = {International journal of geriatric psychiatry},
year = {2022},
doi = {10.1002/gps.5809},
pmid = {36047339},
url = {https://doi.org/10.1002/gps.5809}
}
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Key findings
- This study included 407 participants (96 Thal, 405 Braak, and 406 CERAD).
- Those who had recently active depression (within previous 2 years) but not remote depression only were more likely to have higher Thal phase score compared to those without a history of depression (OR = 3.74; 95% CI, 1.15-12.17; p = 0.028).
- No significant associations between recent depression and Braak or CERAD scores were observed.
- Our findings indicate that the association between late life depression and Alzheimer's neuropathology is associated with spread of amyloid pathology beyond the neocortex to include allocortical and subcortical regions critical for regulation of mood and motivated behavior.
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Study details
- Study designcross-sectional
- Participants407
- Effect sizeOR = 3.74
- Evidence strengthLow
How this study scored 63/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 35 of the 56 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 407 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36047339) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 35 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 35 of the 56 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
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