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Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes
Sayoni Saha, Daniel J Hatch, Kathleen M Hayden, David C Steffens, Guy G Potter. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016-06-06
Topic: Brain imaging, connectivity and assessment
Higher scores on the appetite and weight loss symptom factor were associated with an increased hazard of both AD and non-AD dementia. This factor was moderated by age at first depression onset, such that higher scores were associated with higher risk of non-AD dementia when depression first occurred earlier in life. Other depression symptom factors and overall depression severity were not related to risk of AD or non-AD dementia. Results suggest greater appetite/weight loss symptoms in active episodes of LLD are associated with increased likelihood of AD and non-AD dementia, but possibly via different pathways moderated by age at first depression onset. Results may help clinicians identify individuals with LLD at higher risk of developing AD and non-AD dementia and design interventions that reduce this risk.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Saha, S., Hatch, D. J., Hayden, K. M., Steffens, D. C., & Potter, G. G. (2016). Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2016.05.004
Vancouver
Saha S, Hatch DJ, Hayden KM, Steffens DC, Potter GG. Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2016. doi:10.1016/j.jagp.2016.05.004. PMID: 27555110.
BibTeX
@article{saha2016-27555110,
author = {Saha, Sayoni and Hatch, Daniel J and Hayden, Kathleen M and Steffens, David C and Potter, Guy G},
title = {{Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2016},
doi = {10.1016/j.jagp.2016.05.004},
pmid = {27555110},
url = {https://doi.org/10.1016/j.jagp.2016.05.004}
}
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Key findings
- Higher scores on the appetite and weight loss symptom factor were associated with an increased hazard of both AD and non-AD dementia.
- This factor was moderated by age at first depression onset, such that higher scores were associated with higher risk of non-AD dementia when depression first occurred earlier in life.
- Other depression symptom factors and overall depression severity were not related to risk of AD or non-AD dementia.
- Results suggest greater appetite/weight loss symptoms in active episodes of LLD are associated with increased likelihood of AD and non-AD dementia, but possibly via different pathways moderated by age at first depression onset.
- Results may help clinicians identify individuals with LLD at higher risk of developing AD and non-AD dementia and design interventions that reduce this risk.
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Study details
- Participants290
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 290 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27555110) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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