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Home › Research › Topic

Brain imaging, connectivity and assessment

1,533 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. AI on Alzheimer Disease: Large-Scale Reproduction Shows the Field’s Hypotheses Cannot Be Distinguished on Common Data

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-27 End-of-life care

    After more than three decades of intensive research, Alzheimer disease care remains largely palliative, and the field has drawn sustained criticism, both for that reason and for pursuing some directions of inquiry over others.

  2. Sensorimotor Characterization of Alzheimer’s Disease Using Virtual Reaching and Catching Tasks

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-27 Getting a diagnosis

    Individuals with MCI and AD exhibit marked deficits in the performance and accuracy of upper-limb reaching and catching movements when assessed in a VR environment.

  3. Auditory brainstem response latencies, but not amplitudes, are associated with gray matter volumes across the human auditory pathway in older adults

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-26 Risk factors

    ABR latencies, rather than amplitudes, showed significant associations with regional gray matter volumes.

  4. Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-25 Brain scans and imaging

    Amyloid-β and tau, pathological hallmarks of AD, silently accumulate years before clinical symptoms’ onset and are associated with neuronal dysfunction and cognitive impairment.

  5. Spoken Recall Reveals Lexical and Mnemonic Function Differences in Temporal Lobe Epilepsy Patients

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-25 Digital health tools

    We examined whether natural language processing and acoustic analysis of spoken biographical recall could identify lexical and temporal speech features associated with language and memory performance in TLE.

  6. Cognitive Performance in Spouses of Individuals with Alzheimer’s Disease: A Controlled Cross-Sectional Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-25 Cognitive tests and assessment

    We compared global and domain-level cognitive performance in older adults without a prior dementia diagnosis based on whether their cohabiting spouse had Alzheimer’s disease.

  7. Reliability and disease sensitivity are dissociable properties of EEG foundation-model representations

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-24 Lewy body dementia

    Only the reliability half of that contrast is individually significant.

  8. Calibration-Aware and Interpretable Graph Learning for Multi-Cohort Diffusion Connectome Brain-Age Modeling

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-24 Long-term cohort studies

    Age-bias-corrected brain-age gap was most consistently associated with reduced diffusion-derived microstructural integrity and structural-network organization across cohorts.

  9. Chronic Migraine and Alzheimer’s Dementia: A Candidate Mechanistic Route, and the Evidence That Would Test It

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-08-20 Biomarkers

    The association declines monotonically as control over ascertainment improves.

  10. Retrospective Forecasting and Long-Term Projection of Alzheimer’s Disease Spreading

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-20 How common it is

    The dynamics of Alzheimer’s disease spread in aging groups of population are described using an Inflow-Outflow Model.

  11. Biomarker fidelity score: A quantitative framework for individual-level validation of explainability methods in 3D Alzheimer’s disease MRI classification

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-20 Long-term cohort studies

    Explainability methods applied to deep learning models for Alzheimer’s disease neuroimaging produce attribution maps that vary substantially across methods and architectures, yet no validated quantitative framework exists for determining which method most faithfully localises attribution signal within established AD neuroimaging biomarker anatomy at the individual subject level.

  12. Stable brain architecture but flexible dynamics: distinct structure - function coupling signatures link aging and genetic Alzheimer's risk to cognitive decline in 34,067 adults

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-20 Long-term cohort studies

    Understanding how a stable structural connectome supports flexible cognition, especially in aging, is a fundamental question in neuroscience.

  13. Neuroimaging of affective symptoms in Lewy body dementia: A systematic review

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-17 Clinical safety

    Affective symptoms, such as depression, anxiety and apathy, are highly prevalent in cognitively impaired Lewy body disease (LBD) groups, including Parkinson’s disease dementia and dementia with Lewy bodies.

  14. High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsy

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-13 Risk factors

    Our findings indicate that HFOs likely arise from different neuronal populations and are generated through distinct mechanisms in these two models.

  15. Effectiveness of Modern Diagnostic and Therapeutic Interventions for Major Neurological Disorders: A Systematic Literature Review

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-12 Treatments

    From 464 identified records, 30 peer-reviewed primary studies met all eligibility criteria following the exclusion of low-quality sources and unindexed preprints.

  16. Effect of glycosylated hemoglobin on cognitive impairment related to White Matter Hyperintensity in non diabetes patients: A retrospective study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-12 Cognitive tests and assessment

    HbA1c levels had warning value for cognitive impairment in non diabetes patients with WMH, and a nonlinear correlation exists between HbA1c and WMH-related cognitive impairment.

  17. Cognitive Stimulation and Training in People with Mild-to-Moderate Alzheimer’s Disease: A Scoping Review

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-08-10 Cognitive tests and assessment

    Of 352 records identified, five studies involving 245 participants were included.

  18. Treatment of obstructive sleep apnea may contribute to long-term stabilisation of memory in Alzheimer's and vascular dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-10 Risk factors

    Controlling for baseline differences, treatment of OSA improved delayed recall and may reduce the slope of memory decline in Alzheimer’s disease and vascular dementia.

  19. A Biologically Constrained Continuous-Time Framework for Long-Horizon Cognition Forecasting in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-08-10 Cognitive tests and assessment

    Accurate long-term forecasting of cognitive trajectories across the Alzheimer’s disease continuum is essential for early intervention, personalized prognosis, patient stratification, and clinical trial enrichment.

  20. Differential associations of insulin resistance with anterior hippocampal volume in mild cognitive impairment and Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-10 Cognitive tests and assessment

    Insulin resistance is increasingly recognized as a metabolic factor associated with Alzheimer’s disease (AD); however, its relevance to hippocampal structural changes—a key pathological feature of AD—across disease stages is not fully understood.

  21. The effectiveness and safety of high-intensity interval training, yoga and intermittent hypoxia-hyperoxia exposure on cognitive performance and health in individuals with mild cognitive impairment (KAYH): a study protocol for a randomized, sham-controlled trial

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-08-07 Prevention trials

    Individuals diagnosed with mild cognitive impairment (MCI) have an increased risk of developing dementia.

  22. Conditional Latent Diffusion for Synthetic Brain MRI in Alzheimer’s Disease: A Preprocessing-Focused Pipeline

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-08-07 Digital health tools

    Alzheimer’s disease (AD) detection from structural magnetic resonance imaging (MRI) using deep learning depends on large, labelled datasets.

  23. Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer’s disease continuum

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-07 Cognitive tests and assessment

    While loss of NMDA receptors (NMDARs) is associated with Alzheimer’s disease (AD) severity, the effect of sex or the relationship between regional NMDAR density and antemortem cognitive status across the AD spectrum has not been examined.

  24. Predicting Cognitive Function Using Transformer-Derived Speech Representations and Longitudinal Coherence Features

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-08-06 Cognitive tests and assessment

    Dementia affects more than 55 million people worldwide, and its progressive decline is difficult to track using infrequent in-person assessments, which can miss subtle changes between visits and add to clinician burden.

  25. The Ignite app detects early cognitive impairment and tracks disease severity in genetic frontotemporal dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-03 Cognitive tests and assessment

    Ignite is a sensitive digital cognitive assessment capable of detecting early cognitive changes in genetic FTD and demonstrates improved discrimination compared with standard neuropsychological measures at milder disease severity.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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