Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort.
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Most veterans with LLE/AD taking statins for secondary prevention do not discontinue statins following CLC admission.
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It is unclear what non-pharmacological interventions to prevent cognitive decline should comprise.
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In this study, we explored whether several individual self-reported health behaviors were associated with cognitive decline when considered simultaneously, using data from the Wisconsin Registry for Alzheimer's Prevention (WRAP), an Alzheimer's disease risk-enriched cohort who were non-demented and in late midlife at baseline.
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This review of reviews provides a comprehensive and systematic overview of epidemiological evidence from previously conducted research to assess the associations of physical activity with physical and mental health outcomes in older adults.
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Overall, the psychological intervention and cognitive training may be beneficial to cognitive function and psychological well-being.
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The purpose of the present study was to explore the effects of computer-based multidomain cognitive training program on Greek patients with Mild Cognitive Impairment (MCI).
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An extensive literature on childhood adversity and neurodevelopment has emerged over the past decade.
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High levels of caregiver burden are present in a large proportion of caregivers of people with dementia and this increases over time for those without services.
Why it matters
This three-year study found that caregiver burden was common and increased over time for caregivers of patients not receiving services, while it did not change for those receiving services or residential care. It identifies factors linked to greater burden but does not test a treatment for Alzheimer's disease itself.
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A cohort of 4 522 160 US veterans (4 243 462 [93.8%] male; median [interquartile range] age, 64.1 [55.7-75.5] years; 3 702 942 [82.0%] white, 667 550 [14.8%] black, and 145 593 [3.2%] other race) was followed up for a median (interquartile range) of 10.0 (6.8-10.2) years.
Why it matters
This cohort study of US veterans estimated the burden of death associated with PM2.5 air pollution for several causes, including cardiovascular disease and cerebrovascular disease. It concerns mortality burden from air pollution and does not address treating, curing, or preventing Alzheimer's disease.
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Our review suggests that MNPIs may improve the global, executive function and memory of PWD in NHs.
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Change in occupational performance predicted change in depressive symptoms.
Why it matters
In this small secondary analysis of 40 people with mild cognitive impairment, those in the daily engagement group showed significant increases in confidence and physical function, and change in self-rated performance predicted change in depressive symptoms. It concerns activity and well-being in mild cognitive impairment, not treating, curing or preventing Alzheimer's disease.
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Cognitive training is a popular intervention aimed at attenuating age-related cognitive decline, however, the effects of this intervention on brain structure and function have not been thoroughly explored.
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Even though the provision of PC was empirically recognised as a care step in the management of dementia, there are barriers that hinder access of patients with dementia to appropriate facilities.
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Whether the cognitive benefits of physical exercise can improve the overall well-being of this group remains unknown.
Why it matters
In this randomized controlled trial, older people with mild cognitive impairment in the aerobic exercise group had significantly greater improvement in cognitive function. It is a single trial in people with mild cognitive impairment and does not show that exercise prevents or cures Alzheimer's disease.
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Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research.
Why it matters
This validation study checked how accurately dementia diagnoses in UK Biobank primary care, hospital and mortality records matched expert review of medical records, finding positive predictive values of roughly 50% to 87% depending on the dataset and dementia type. It is about identifying dementia cases for research, not about treatment, cure or prevention.
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Enrollees in a comprehensive dementia care comanagement program had high engagement in advance care planning, high rates of hospice use, and low acute care utilization near the end of life.
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Of 6,379 citations, 36 articles met inclusion criteria.
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There is a strong association between PM 2.5 exposure and neurological disorders.
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Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies.
Why it matters
This meta-analysis of longitudinal studies found that people with REM sleep behavior disorder had a high estimated risk of developing a neurodegenerative disease over long-term follow-up, with most converting to Parkinson's disease and then dementia with Lewy bodies. It suggests that future studies should target REM sleep behavior disorder as a precursor of neurodegeneration to develop protective trials.
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Retinal structures may serve as a biomarker for dementia, but longitudinal studies examining this link are lacking.
Why it matters
This study examined whether the thickness of inner retinal layers, measured with optical coherence tomography, is associated with dementia in a general population of Dutch adults. It is an observational study, so it cannot show that retinal changes cause dementia or that eye testing prevents it.
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People from the black ethnic group had a higher incidence of dementia diagnosis and those from the Asian ethnic group had lower incidence compared with the white ethnic group.
Why it matters
Dementia diagnosis rates in UK primary care rose between 2007 and 2015 and differed by ethnic group, with higher rates in black women and men and lower rates in Asian women. These are patterns of diagnosis, not of disease cause or treatment, and the study estimated that many people with dementia may go undiagnosed.
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We concluded that cognitive training along with active tDCS is a useful combined approach in the management of mood and cognitive dysfunctions in PD.
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The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome.
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The growing prevalence of neurodegenerative disorders associated with aging and cognitive decline has generated increasing cross-disciplinary interest in non-pharmacological interventions, such as computerized cognitive training (CCT), which may prevent or slow cognitive decline.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Research Gaps and Controversies in Chronic Traumatic Encephalopathy: A Review
- The Clinician Interview-Based Impression (CIBI): a clinician's global change rating scale in Alzheimer's disease
- Advance care planning in nursing homes: correlates of capacity and possession of advance directives
- White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
- Running‐Centred Injury Prevention Support: A Scoping Review on Current Injury Risk Reduction Practices for Runners
- Challenges and opportunities in understanding dementia and delirium in the acute hospital
- Adverse Social Exposome During the Life Course and Vascular Brain Injury
- Barriers to telehealth access among homebound older adults
- Hippocampal correlates of pain in healthy elderly adults: a pilot study
- Machine learning approaches to racial/ethnic differences in social determinants of mild cognitive impairment and its progression to dementia in the All of Us Research Program