Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Phase 3 (NIH stage 1B) is a feasibility randomized controlled trial of the intervention versus the Health Education Program control.
Why it matters
This is a protocol for a feasibility trial of a mindfulness and self-compassion program for caregivers of people with dementia. No results are reported, and it targets caregiver stress rather than treating or preventing Alzheimer's disease.
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58/100
The analysis involved 4674 participants (2904 [62.13%] female and 1770 [37.87%] male; mean [SD] age, 41.51 [13.41] years).
Why it matters
This study examined links between social vulnerability and mental health and substance use disorder diagnoses and treatment. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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The study included 234 patients (mean 71 years, 42% female).
Why it matters
Among 234 patients with intracerebral hemorrhage, more than 25% were not assessed for hyperlipidemia and diabetes in the year around hospitalization, and less than half of those with off-target values received treatment intensification. Higher area deprivation index was linked to lower odds of blood pressure, LDL, and HbA1c measurement before the hemorrhage, but not with management during or after hospitalization.
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Epilepsy has been associated with cognitive impairment and potentially dementia in older individuals.
Why it matters
This cross-sectional study using UK Biobank data compared dementia risk in people with focal epilepsy, stroke, and migraine, and examined how cardiovascular risk factors affect that risk. It cannot show cause or prevention, and the findings are limited to associations.
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The S@H study is the first randomized trial of a firearm safety decision aid for ADRD caregivers.
Why it matters
This is a protocol for a trial testing a web-based decision aid to help caregivers of people with dementia manage firearm access. Enrollment began in May 2022, and no results on the aid's effectiveness are reported yet.
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Fourteen- and 16-second cut points for the CST are suitable to identify people at higher risk of functional decline among older adults in Mexico and Toledo, Spain.
Why it matters
This study developed age-stratified cutoffs for the 5-repetition chair stand test (14 seconds for ages 70-79 and 16 seconds for ages 80+) that identified older adults at higher odds of incident disability in daily living activities. It is a screening tool for mobility impairment, not a treatment or prevention for Alzheimer's disease.
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Long-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging.
Why it matters
In this observational analysis of 1673 older adults, long-term use of urate-lowering therapies was not associated with reduced cognitive decline over five years. It does not support these drugs as a way to prevent cognitive decline.
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Sedentary behavior (SB) is associated with cardiometabolic disease and mortality, but its association with dementia is currently unclear.
Why it matters
In this UK Biobank cohort, leisure-time sedentary behaviors such as television watching and computer use were tracked in people aged 60 or older, and 3,507 were diagnosed with all-cause dementia. The study examined whether these sedentary behaviors were linked to dementia regardless of how much physical activity people did.
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The number of older adults with dementia in the US and globally is projected to increase as a result of population aging and growth.
Why it matters
This study calculated that vision impairment had a population attributable fraction of 1.8% for dementia, suggesting more than 100,000 prevalent dementia cases in the US could potentially have been prevented through healthy vision. It is a cross-sectional estimate of modifiable risk factors and does not test any treatment or cure.
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This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors.
Why it matters
This UK Biobank cohort study investigated whether grip strength is associated with dementia incidence and mortality. It examines an association with a physical measure, so it does not show that improving grip strength prevents or treats Alzheimer's disease.
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Sleep is essential for life, including daily cognitive processes, yet the amount of sleep required for optimal brain health as we grow older is unclear.
Why it matters
This study examined the relationship between sleep duration, cognitive performance, and brain structure in middle-to-late life individuals. It is an observational study of a possible risk factor and does not test any treatment, cure, or prevention.
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Beneficiaries included 2,713,573 White, 251,958 Black, 196,845 Hispanic, 95,719 Asian, 11,727 American Indian/Alaska Native, and 63,795 of other race/ethnicity.
Why it matters
This study found that using instrumental variables, Medicare Annual Wellness Visit receipt increased dementia diagnoses by 0.47 percentage points, 15% over baseline, with larger increases among Blacks. It suggests that increasing Annual Wellness Visit take-up and supporting physicians' performance of cognitive assessment may further improve dementia detection in the population and among groups at higher risk of undiagnosed dementia.
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This study aimed to examine the therapeutic mechanism of the benefit-finding therapeutic (BFT) intervention that used cognitive reappraisal and alternative thinking to construct positive aspects of caregiving (PAC), in a cluster-randomized controlled trial for Alzheimer caregivers.
Why it matters
This trial examined a benefit-finding group intervention for Alzheimer family caregivers, not a treatment for the disease itself. It found that improved self-efficacy in controlling upsetting thoughts partly explained the intervention's effect on caregivers' depressive symptoms, which concerns caregiver support rather than treating, curing, or preventing Alzheimer's disease.
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Care quality has important implications for people with dementia.
Why it matters
Among Australian aged care users with dementia, four indicators of dementia care quality changed little over time, with only a slight decrease in antipsychotic dispensing and a slight increase in high sedative load and dementia and delirium-related hospitalisations, plus marked geographic variation in cholinesterase inhibitor and memantine dispensing. The authors conclude that existing strategies to improve national performance on these indicators appear insufficient, so this is about care quality, not treating, curing, or preventing dementia.
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The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention, diagnosis and management must evolve as new treatment paradigms and disease-modifying therapies (DMTs) emerge.
Why it matters
This review and synthesis offers practical recommendations for primary care clinicians on timely, accurate diagnosis of symptomatic Alzheimer's disease, noting that pathology builds silently for decades before impairment is detectable. It focuses on diagnosis and preventive intervention in midlife, not on a treatment or cure.
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58/100
Of 502 535 participants in UK Biobank, 143 215 met the inclusion criteria and were included in our analyses. 68 500 (47·8%) of the participants were pre-frail and 5565 (3·9%) were frail.
Why it matters
In this UK Biobank cohort, pre-frailty and frailty were associated with higher risk of developing all-cause dementia, and weight loss, tiredness, low grip strength and slow gait speed were independent contributors. Because it is an observational study, it cannot prove that reducing frailty prevents dementia.
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Benefit-finding is an efficacious intervention for depressive symptoms in Alzheimer caregivers, with strong effects in the medium-term post-intervention and possible moderate effects in the longer-term post-intervention.
Why it matters
In this trial of 96 caregivers, a benefit-finding intervention reduced depressive symptoms at 4 months compared with control conditions, but the effects diminished over time. By 10 months, the intervention was no different from standard psychoeducation, though a moderate effect remained compared with simplified psychoeducation.
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This association may be partially mediated by air pollution, whereas noise exposure did not affect associations.
Why it matters
This population-based cohort study found that road proximity was associated with incidence of non-Alzheimer's dementia, Parkinson's disease, Alzheimer's disease, and multiple sclerosis. It suggests that this association may be partially mediated by air pollution, whereas noise exposure did not affect associations, and there was some evidence of protective effects of greenness.
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58/100
Accounting for educationalfactors, vascular factors, and Aβ burden diminished, but did not eliminate, racial differences in PACC5 performance longitudinally.
Why it matters
In 296 clinically normal participants, Black participants had lower baseline scores on a cognitive composite and declined faster over time than White participants, even after adjusting for education, vascular factors, and amyloid. Amyloid burden, vascular risk scores, and white matter hyperintensities did not differ by race.
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Our model could aid GPs or health service planners with the early detection of dementia.
Why it matters
This study used machine learning on UK primary care records to identify patients with undetected dementia, based on data from 93,120 patients. It is about improving detection and diagnosis, not about treating, curing or preventing dementia.
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Neurodegenerative diseases are characterized by the progressive functional loss of neurons in the brain, causing cognitive impairment and motoneuron disability.
Why it matters
This systematic review found that the Mediterranean diet, nutritional support, and calorie-controlled diets had a protective effect against cognitive decline and Alzheimer's disease, while malnutrition and insulin resistance were significant risk factors. It also found that omega-3 and omega-6 and vitamin supplementation seemed less effective in protecting against neuron degeneration.
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The gap between predicted brain age using magnetic resonance imaging (MRI) and chronological age may serve as a biomarker for early-stage neurodegeneration.
Why it matters
This study tested whether the gap between predicted brain age from MRI and actual age could serve as a risk biomarker for incident dementia. It is about predicting risk, not about treating, curing or preventing Alzheimer's disease.
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Three themes emerged from 29 included studies: self-care needs and behaviors of ICGs, barriers to performing self-care, and enablers of self-care.
Why it matters
This systematic review synthesized evidence on the self-care needs and behaviors of informal caregivers of people with dementia, identifying needs such as sleep, social engagement and leisure activities, along with barriers and enablers. It addresses caregiver support rather than treating, curing or preventing Alzheimer's disease.
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Multiple logistic regression analysis revealed increased likelihood of multiple system atrophy versus Lewy body disease and progressive supranuclear palsy if a patient developed orthostatic hypotension or urinary incontinence with the requirement for urinary catheters [multiple system atrophy versus Lewy body disease: odds ratio (OR): 2.0, 95% confidence interval (CI): 1.1-3.7, P = 0.021; multiple system atrophy versus progressive supranuclear palsy: OR: 11.2, 95% CI: 3.2-39.2, P < 0.01].
Why it matters
This study is about improving the diagnosis of multiple system atrophy, a different brain disease, by using symptoms like orthostatic hypotension and urinary incontinence. It does not address treating, curing, or preventing Alzheimer's disease.
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Anxiety disorders were the most common class of disorders both in the 12 months before the interview (weighted prevalence 5·0%, 4·2-5·8) and in lifetime (7·6%, 6·3-8·8).
Why it matters
A national survey of mental disorders in China (data from 2013) estimated that 5·6% of people aged 65 or older had dementia, with a plausible range of 3·5–7·6%. Anxiety disorders were the most common class overall (5·0% in the past year). It is a descriptive count of cases: it gives a baseline for how common dementia is in China but no evidence about its causes, treatment or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Dissecting the genetic and proteomic risk factors for delirium
- Transitioning From Community-Based to Institutional Long-term Care: Comparing 1915(c) Waiver and PACE Enrollees
- Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population
- Incidence of dementia in a community-dwelling Brazilian population
- A National Examination Of Long-Term Care Setting, Outcomes, And Disparities Among Elderly Dual Eligibles
- Abstract 9: Alirocumab Prior Authorization Approval and Prescription Fill Rates Among Medicare Advantage Patients in a Large US Managed Care Plan
- Association between late-life body mass index and dementia: The Kame Project
- Long-term outcomes of deep brain stimulation in Parkinson disease
- Association Between Circadian Rest-Activity Rhythms and Incident Dementia in Older Adults
- Imaging retina to study dementia and stroke