Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features.
Why it matters
This cohort study describes the design and first results of a study of patients with subjective cognitive decline. It found that this group is heterogeneous, with some having preclinical Alzheimer's disease and others having subthreshold psychiatric features, and that certain criteria were associated with preclinical Alzheimer's disease.
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Most families chose comfort as the primary GOC.
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To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison.
Why it matters
This analysis externally validated four existing dementia prediction models in people aged 55 and older from the Rotterdam Study. It concerns risk prediction tools, not treating, curing or preventing Alzheimer's disease.
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Our results demonstrate delirium is a significant marker of mortality among seniors in the ED, and mortality risk is most salient in the first 3 months following an ED visit.
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67/100
This study provides evidence for sex differences in the progression to cognitive impairment in PD, while specific cognitive features become more important indicators of progression with impending conversion to PDD.
Why it matters
In Parkinson's disease, male sex was the main predictor of progressing from no cognitive impairment to mild cognitive impairment or dementia, and males progressed more rapidly than females. Among those with Parkinson's mild cognitive impairment, processing speed and working memory were associated with conversion to dementia, which may help plan care and trials.
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We demonstrated the higher short-term improvement of cognitive functions scores in individuals of the MedDiet plus low dose of extravirgin olive oil rather than MedDiet alone.
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Palliative care is related to reduced life-sustaining treatments for patients with dementia.
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This population-based study in community-dwellers aged 70 years or over suggested that multidomain intervention and n3 PUFA supplementation have not significant effects on cognitive function change in frail older adults with memory complaints.
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A novel method using an EHR phenotype plus brief medical record review is effective to identify hospitalized patients with late-stage dementia.
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Evidence that short-term, single-component physical activity interventions promote cognitive function and prevent cognitive decline or dementia in older adults is largely insufficient.
Why it matters
Evidence was insufficient to conclude whether aerobic training, resistance training, or tai chi improves cognition, and low-strength evidence showed multicomponent physical activity had no effect on cognitive function. Low-strength evidence showed a multidomain intervention of physical activity, diet, and cognitive training improved several cognitive outcomes.
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In older adults with normal cognition, training improves cognitive performance in the domain trained.
Why it matters
This review of trials lasting at least six months found that cognitive training did not improve performance in people with mild cognitive impairment. For healthy older adults, training improved some cognitive measures, but the evidence on preventing dementia is limited.
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Patients with FTLD were distributed between FTLD-tau (34 patients: 10 corticobasal degeneration, nine progressive supranuclear palsy, eight Pick's disease, three frontotemporal dementia with parkinsonism associated with chromosome 17, three unclassifiable tauopathy, and one argyrophilic grain disease); FTLD-TDP (55 patients: nine type A including one with motor neuron disease, 27 type B including 21 with motor neuron disease, eight type C with right temporal lobe presentations, and 11 unclassifiable including eight with motor neuron disease), FTLD-FUS (eight patients), and one patient with FTLD-ubiquitin proteasome system positive inclusions (FTLD-UPS) that stained negatively for tau, TDP-43, and FUS.
Why it matters
This study found that the six core behavioural variant frontotemporal dementia features were similar in FTLD-tau and FTLD-TDP, so these features alone cannot separate patients by major molecular class. Data-driven classification of the 10 most common pathological diagnoses was most accurate at up to 60.2% using a combination of known predictive factors, so accurate diagnosis from clinical features remains limited.
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Elevated blood pressure during midlife, persistence of elevated blood pressure into late life, and, among nonhypertensives, a steep decline in blood pressure during mid- to late life were associated with an increased dementia risk in a community-based cohort.
Why it matters
In 1,440 Framingham participants, high blood pressure in midlife and its persistence into late life were linked to higher dementia risk, and a steep drop in blood pressure among those without hypertension was also linked to higher risk. This suggests that blood pressure patterns over time may matter for dementia risk, but it did not test whether treating blood pressure prevents dementia.
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Main results We identified no studies which met the inclusion criteria.
Why it matters
This systematic review identified no studies that met its inclusion criteria on assistive technology for memory support in dementia. No conclusion about benefit or harm can be drawn from it.
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67/100
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.
Why it matters
This 2017 consensus report from the DLB Consortium updates its earlier, widely used criteria for diagnosing dementia with Lewy bodies. It separates clinical features from diagnostic biomarkers, gives more weight to REM sleep behavior disorder and MIBG myocardial scintigraphy, and adjusts the pathology criteria to take account of co-existing Alzheimer disease brain changes. It states that its treatment recommendations are largely based on expert opinion because randomized controlled trials in DLB are few.
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Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown.
Why it matters
This study measured blood flow in the brain and then followed participants to see who developed dementia, to test whether reduced blood flow comes before cognitive decline. If poor brain perfusion precedes dementia, it could be a target for prevention, but this study only examined the association over time.
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Fasting lipid fractions (triglycerides [TGs], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC]) were studied as continuous variables, and results are reported per SD increase of each lipid fraction.
Why it matters
In this cohort, higher LDL cholesterol and total cholesterol were linked to higher Alzheimer risk, but the link weakened after accounting for APOE epsilon4. Triglycerides and HDL cholesterol were not linked to dementia risk after accounting for vascular risk factors.
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This review has shown that wearable systems are used mostly for the monitoring and provision of feedback on posture and upper extremity movements in stroke rehabilitation.
Why it matters
This review is about wearable systems for upper body rehabilitation, mostly in stroke rehabilitation, and does not address treating, curing, or preventing Alzheimer's disease. Only three of the included studies conducted clinical trials, including one randomized clinical trial.
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67/100
Fifteen studies met inclusion criteria.
Why it matters
This systematic review of community-dwelling people with cognitive impairment or dementia found that new-learning, memory, and executive functioning were associated with improved medication adherence and were the focus of most studies. It extracted data on adherence factors and strategies to improve medication adherence, comparing them with cognitively intact populations when available.
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Later GOCDs were associated with greater risk of aggressive interventions and death as an inpatient and greater odds of ICU admission.
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The Mediterranean-style diet (MedDiet) involves substantial intake of fruits, vegetables, and fish, and a lower consumption of dairy, red meat, and sugars.
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These studies show that remote physical activity monitoring is feasible in neurological diseases, including in people with moderate to severe neurological disability.
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We found no definitive evidence on effectiveness, or lack of effectiveness, of specific interventions but studies were small and short term.
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Frailty and depression are important issues affecting older adults.
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Seventeen randomized clinical trials tested decision tools in serious illness.
From across this topic
9 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Epidemiology and risk factors of fungal pathogens in sepsis: a prospective nationwide multicenter cohort study
- Communication and end-of-life care in dementia: insights from a close family member working in healthcare
- Multidomain interventions for prevention of dementia: Achievements, challenges and future perspectives
- Potential Benefits of Physical Activity in MCI and Dementia
- Digital Detection of Dementia in Primary Care: A Randomized Clinical Trial
- Development and Validation of a Prognostic Survival Model With Patient-Reported Outcomes for Patients With Cancer
- Mind Care: The Moral Significance of the Dementia Caregiving Dyad
- The attitudes and practices of general practitioners regarding dementia diagnosis in Ireland
- Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies