Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Combining physical exercise with cognitive training is a popular intervention in dementia prevention trials and guidelines.
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Cognitive decline and dementia incidence have also been consistently associated with exposure to air pollution.
Why it matters
This review reports that cognitive decline and dementia incidence have been consistently associated with exposure to air pollution. It does not describe any treatment or prevention effect.
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Data collected from clinical trials and cohort studies, such as dementia studies, are often high-dimensional, censored, heterogeneous and contain missing information, presenting challenges to traditional statistical analysis.
Why it matters
This study compared machine learning methods for survival analysis to predict time until dementia using clinical data. It notes there is no cure for dementia and no treatment that can change its course, and the work is about prediction models, not treatment or prevention.
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This kMCT drink improved cognitive outcomes in MCI, at least in part by increasing blood ketone level.
Why it matters
In this 6-month randomized controlled trial, a ketogenic drink improved several cognitive outcomes in people with mild cognitive impairment compared with placebo, and some outcomes correlated positively with plasma ketones. The authors say the data support further assessment of mild cognitive impairment progression to Alzheimer's disease.
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ACP is complex, and trial characteristics were heterogeneous.
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Our results suggest that having an increased body weight or abdominal obesity are associated with increased dementia incidence.
Why it matters
This study of older English adults investigated whether increased body weight or central obesity were associated with a higher risk of developing dementia over a mean follow-up of 11 years. It examines obesity as a risk factor and does not report a treatment, cure, or prevention.
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Why it matters
The 2020 report of the Lancet Commission on preventing dementia, intervening once it is present, and caring for people who have it. It gathers and weighs existing evidence across those areas rather than testing a treatment of its own.
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Real-world deprescribing patterns of antihypertensives among NH residents with HTN and LLE/AD appear to reflect variation in recommendations for HTN treatment intensity and individualization of patient care in a population with potential overtreatment.
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67/100
Among 34 349 participants, 19 378 individuals who were free of stroke and dementia and had longitudinal BP, cognitive, and covariate data were included in the analysis.
Why it matters
Black individuals had faster declines in global cognition and memory than white individuals, and the study examined whether cumulative blood pressure levels explained this difference. It addresses racial differences in cognitive decline and does not test a treatment, cure, or prevention for Alzheimer's disease.
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Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals.
Why it matters
This paper describes a fast deep learning pipeline for automatically processing structural brain MRI scans, replicating FreeSurfer's anatomical segmentation, surface reconstruction, and cortical parcellation. It is a neuroimaging analysis tool and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Effective learning in old age, particularly in those at risk for dementia, is essential for prolonging independent living.
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This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults.
Why it matters
This randomized controlled trial gave a virtual reality-based intervention to 68 older adults with mild cognitive impairment and measured cognition, brain activity and physical function. It is a small, single trial, so it cannot yet show whether such programs prevent or treat Alzheimer's disease.
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The incidence and prevalence of delirium in hospitals appears to be stable, though publication bias may have masked true changes.
Why it matters
This systematic review found that delirium occurred in 23% of adult medical inpatients overall, with no change in occurrence from 1980 to 2019. Delirium remains consistently under-diagnosed despite being associated with a wide range of adverse patient safety outcomes.
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Midlife vascular risk burden is associated with late-life dementia.
Why it matters
This British birth cohort study examined whether vascular risk in early adulthood, midlife and late life is associated with late-life brain structure and pathology. It reports associations with brain measures, so it does not show that modifying vascular risk prevents or treats Alzheimer's disease.
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Extrapolating results to the US population, we estimate that annually nearly a million individuals who are likely eligible for hospice die without its services.
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As there is currently no cure for dementia, there is an urgent need for preventive strategies.
Why it matters
This review of 56 articles found that eating closer to a Mediterranean diet was linked to better thinking scores in 17 of 25 long-term studies and to lower Alzheimer's risk in 6 of 8 long-term studies, but only 1 of 3 trials showed better thinking scores. Far fewer studies looked at the DASH and MIND diets, though some found similar links. These are associations rather than proof that a diet prevents Alzheimer's, and the authors found little evidence for dementia in general.
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CCT was most effective in cognitive rehabilitation, particularly in the subdomain of memory.
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Over a median of 18 years, 1180 former soccer players (15.4%) and 3807 controls (16.5%) died.
Why it matters
Former professional soccer players had higher mortality from neurodegenerative disease than matched controls, though all-cause mortality was lower before age 70. This is an observational comparison of death records and does not show that soccer causes dementia or how to prevent it.
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The findings suggest that midlife HI is a risk factor for temporal lobe volume loss.
Why it matters
In 194 adults whose hearing was tested at an average age of 54.5, poorer hearing (measured in the better ear, and also in the right ear) was associated with faster later-life shrinkage of the right temporal gray matter, right hippocampus and left entorhinal cortex, regions the authors describe as an early Alzheimer's biomarker. Left-ear hearing showed no association. This is an observational study of brain volume, not dementia; it does not show that hearing loss causes Alzheimer's or that treating it would protect the brain.
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Thirty-five studies were analyzed with data from 3268 caregivers (pooled mean age [SD of sample means], 63.48 [5.99] years; 76.7% female) were analyzed.
Why it matters
This meta-analysis of 35 studies found that sleep quality was significantly lower in dementia caregivers than in comparison groups. It is about caregiver sleep and does not test any treatment or cure for Alzheimer's disease.
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Incident AF was associated with an increased risk of dementia, independent of clinical stroke in an elderly population.
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Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear.
Why it matters
This study examined whether daily steps and light-intensity physical activity relate to brain volumes on MRI in Framingham Heart Study participants. It is cross-sectional, so it cannot show that physical activity prevents dementia.
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67/100
The evidence base for treating a range of nonmotor symptoms in PD has grown substantially in recent years.
Why it matters
This review of treatments for non-motor symptoms in Parkinson's disease found no randomized controlled trials meeting criteria for several conditions, including anxiety, REM sleep behavior disorder, and impaired olfaction. Overall treatment options remain limited, and developing and testing new treatments for these symptoms is stated as a top priority.
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The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories.
Why it matters
This machine-learning technique uncovered subgroups with distinct trajectories of regional neurodegeneration in genetic frontotemporal dementia and three subtypes in Alzheimer's disease, and improved prediction of conversion between diagnostic categories. It is a data analysis method for stratifying patients and does not itself test any treatment, cure, or prevention.
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Diabetes and prediabetes accelerate cognitive decline and might predict microvascular lesions among dementia-free older adults.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Conference report: dementia research and care and its impact in Switzerland
- In-home respite care in dementia: An evolutionary concept analysis
- Predictors of Hospital Admission Following Emergency Department Presentation for Falls Among Older Adults: A Retrospective Analysis
- Aging effects on cerebral blood and cerebrospinal fluid flows
- Measuring the Impact of a Full Service Grocery Store in a Food Desert
- Outcomes for Dual-Eligible Beneficiaries With Dementia in Special Needs Plans and Other Medicare Advantage Plans
- Urban Planning for Disaster Risk Reduction and Climate Change Adaptation: A Review at the Crossroads of Research and Practice
- Walking and Talking: Recommendations for Doing Mobile Interviews with Older Adults
- Vitamin E and donepezil for the treatment of mild cognitive impairment
- Can physicians conceive of performing euthanasia in case of psychiatric disease, dementia or being tired of living?