Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Between 1980 and 1987, the number of hospital discharges with total hip replacement (THR) increased by more than 90%, while total hospital discharges fell by more than 10%.
Why it matters
This study examined the growth in total hip replacement surgeries in the 1980s and found that more patients with serious conditions such as dementia were receiving the procedure. It does not test any treatment, cure, or prevention of Alzheimer's disease.
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Cognitive profiles of performances were obtained from a selected group of adult Down syndrome (DS) subjects (n = 20; mean age: 34.5 years; s.d.: 7.7) by means of an ad hoc neuropsychological battery.
Why it matters
This neuropsychological study of 20 adults with Down syndrome found that the mental decline seen with age did not reproduce the cognitive patterns of impairment seen in Alzheimer disease patients. It is a small cognitive study and does not test any treatment or cure.
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The study was conducted in a psychiatric setting that services a large metropolitan population.
Why it matters
This study compared symptoms in black and white psychiatric patients and noted some differences in psychopathology, some possibly due to selection factors. It does not test any treatment, cure or prevention for Alzheimer's disease.
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In 2023, US life expectancy reached 78.5 years and healthy life expectancy 64.5 years, both still below prepandemic 2019 levels, with a persistent 13-14-year gap between life expectancy and healthy life expectancy.
Why it matters
This report describes US trends in chronic disease and disability, noting that Alzheimer's disease climbed in rank as a cause of disability. It does not test any treatment, cure, or prevention.
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Awareness of caregiver distress, burnout, and early grief, as a result of the loss of their loved one’s personhood, has increased.
Why it matters
This review describes the unique palliative care challenges in dementia, including prognostic ambiguity, difficulty expressing pain, and ethical issues around autonomy and dignity. It notes that recent randomized controlled studies of palliative care interventions have shown mixed results regarding effects on the person with dementia, and that a palliative approach is best integrated early.
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Over half of dementia cases remain undiagnosed, with persistent disparities across racial, ethnic, and socioeconomic groups.
Why it matters
This article proposes a pre-diagnosis dementia care navigation framework across six domains to address undiagnosed dementia and diagnostic disparities, and identifies existing reimbursement pathways. It is a framework proposal about improving timely diagnosis, not a treatment, cure or prevention of Alzheimer's disease.
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MDD prevalence was consistently higher among women than men across all regions and age groups, ranging from 4.42%-5.11% in women versus 2.87%-3.41% in men.
Why it matters
This analysis estimated that major depressive disorder accounts for a mean global population-attributable fraction of 4.81% for dementia, with the highest fractions in sub-Saharan Africa and low-SDI regions. The findings highlight geographic inequities in depression-associated dementia risk and the need for stronger mental health systems, rather than testing any treatment or cure.
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34/100
Four attributes distinguished situations in which either approach is preferred: understanding, trust, readiness, and momentum.
Why it matters
This study identified four attributes—understanding, trust, readiness and momentum—that distinguish when different advance care planning approaches are preferred for people with dementia. It is about tailoring care conversations, not treating, curing or preventing Alzheimer's disease.
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Univariate analysis revealed that smoking, moderate aerobic exercise and smartphone use were positively correlated with MMSE score.
Why it matters
In this study, up to one hour of daily aerobic exercise remained positively associated with cognitive scores, and anaerobic exercise and smart device use were linked to better quality of life, while smoking was linked to worse quality of life. These findings suggest exercise and smart device use as promising non-drug approaches, but they do not show that these lifestyle factors prevent or cure dementia.
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Progressive functional decline and behavioral disturbances in people with dementia place sustained emotional and practical demands on family caregivers, often resulting in chronic stress, anxiety, depression, and a high perceived caregiving burden.
Why it matters
In this pilot study, an 8-week online mindfulness program reduced perceived burden, depression, anxiety, and stress among family caregivers of people with dementia. The findings suggest online MBSR is feasible and accessible, though further research is needed.
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A total of 739 patients were included: 504 with AD and 235 with non-AD dementias.
Why it matters
In 739 patients, time to dementia diagnosis was shorter for Alzheimer's disease than for non-Alzheimer dementias, mainly due to longer pre-hospital delays in the non-Alzheimer group. This is about diagnostic timing only and reports nothing about treating, curing, or preventing Alzheimer's disease.
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Neurodegenerative dementias, including Alzheimer's disease and vascular dementia, have long been viewed through a neuron-centric lens.
Why it matters
This review argues that glial cells are central to dementia and examines therapeutic strategies targeting glial pathways. It is a synthesis of research directions, not evidence that any approach treats or prevents Alzheimer's disease.
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The study included seven healthcare workers, five participants with dementia and their caregivers, and 10 persons without dementia.
Why it matters
This qualitative study in rural Cameroon found that community misperceptions about dementia and brain health are common, and multiple barriers to care exist. It does not test any treatment or cure, but highlights the need for multipronged interventions to address stigma, lack of awareness, and limited services.
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The results indicated good usability for the MoCA Duo.
Why it matters
This implementation study found good usability for a tablet-based MoCA administered by medical assistants in general practice, with usability ratings influenced by cognitive status and age. It is about a digital assessment tool and does not treat, cure or prevent Alzheimer's disease.
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=3.40; P=.04). Greater cognitive improvements were associated with younger age, higher functional status, and lower baseline cognitive function.
Why it matters
This single-arm 15-month study found that long-term use of a mobile-based metamemory cognitive training app was associated with cognitive improvements. Because there was no control group and the sample was small, it cannot show that the training treats, cures or prevents Alzheimer's disease.
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In highly segregated counties, Black older adults with elevated CVD demonstrated worse memory than those with lower CVD; in less segregated counties, memory levels did not differ by CVD.
Why it matters
Among 662 Black older adults, those with higher cardiovascular disease measures living in highly segregated counties had worse average memory than those with lower cardiovascular disease. The study found no link between segregation and cardiovascular disease together and the rate of memory decline, so it cannot show that segregation causes memory loss.
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All non-differential bias scenarios were biased toward the null (Table 1).
Why it matters
This study found that if Alzheimer's diagnosis is less sensitive in under-resourced Appalachian counties, the true difference in prevalence between Appalachian and non-Appalachian counties may be underestimated. It is about how disease rates are measured, not about treating, curing, or preventing Alzheimer's disease.
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The mean age of the cohort was 77.4 ± 6.8 years, with 62% males and nearly equal urban–rural distribution.
Why it matters
This cross-sectional study found that EEG abnormalities, including progressive background slowing and higher theta/alpha and delta/alpha ratios, correlated strongly with dementia severity as measured by the MMSE. Quantitative EEG indices may serve as non-invasive markers of cognitive decline, but the study does not test any treatment or prevention.
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Of these, a growing number have secured funding, initiated collaborations, contributed to dementia palliative care research, and increased confidence and comfort with conducting clinical trials (p<.05).
Why it matters
This abstract describes a 10-month training program to equip early- and mid-career researchers to design and conduct clinical trials in dementia palliative care. Since its inception, 53 scholars across three cohorts have completed it, with some securing funding and reporting increased confidence and comfort with conducting clinical trials.
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Artificial intelligence (AI) has gained attention as a tool to support dementia care through efficient and personalized interventions.
Why it matters
In this qualitative study of 19 participants, dementia caregivers in hospice and hospice staff identified both strengths, such as informational support and home symptom monitoring, and concerns about using artificial intelligence in end-of-life dementia care. These are perceptions about care delivery, not evidence that AI treats, cures, or prevents Alzheimer's disease.
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The global increase in dementia cases, which is predicted to exceed 152 million by 2050, poses substantial challenges to healthcare systems and caregiving structures.
Why it matters
This review of 100 dementia-related mobile applications found a predominance of carer resources and support tools, while clinically integrated platforms, cognitive assessments, and adaptive memory aids remain underrepresented. Most apps lack empirical validation and integration with electronic health records, raising concerns about data privacy and informed consent.
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• AT use was limited and AT type used varied by caregiver living arrangement. • Most used ATs: daily living support and risk prevention; risk response least used. • Daily living support ATs linked to fewer care hours. • Risk prevention ATs tied to longer PT, higher CarerQol-7D, and lower SRB scores. • Daily support and risk response ATs most likely to extend PT by over six months.
Why it matters
This survey of 342 informal caregivers in the Netherlands found that daily living support technologies were linked to fewer care hours, while risk prevention technologies were tied to longer perseverance time and higher well-being. The findings concern assistive technology use and caregiver outcomes and do not address treating, curing, or preventing Alzheimer's disease.
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Frontotemporal lobar degeneration (FTLD) represents a heterogeneous group of neurodegenerative disorders with overlapping clinical, pathological, and genetic characteristics.
Why it matters
Increasing evidence indicates that disease mechanisms begin decades before the appearance of clinical symptoms, highlighting the importance of identifying preclinical and prodromal stages of frontotemporal lobar degeneration. Recent advances in biomarker discovery and neuroimaging are enabling earlier diagnosis and intervention, offering the potential to delay phenoconversion and preserve brain function.
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The IVW analysis indicated that antithrombotic agents (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.03-4.34, p = 0.04), HMG CoA reductase inhibitors (OR = 1.36, 95% CI = 1.07-1.72, p = 0.01), and salicylic acid and derivatives (OR = 2.77, 95% CI = 1.44-5.32, p = 0.002) are a strong risk factor for dementia with Lewy bodies (DLB); diuretics (OR = 1.13, 95% CI = 1-1.27, p = 0.047) and calcium channel blockers (OR = 1.16, 95% CI = 1.04-1.29, p = 0.007) might be a risk factor for vascular dementia; thyroid preparations (OR = 1.03, 95% CI = 1.01-1.06, p = 0.01), diuretics (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), and immunosuppressants (OR = 1.07, 95% CI = 1.01-1.12, p = 0.001), are a risk factor for frontotemporal dementia; HMG CoA reductase inhibitors is a risk factor for dementia in Alzheimer disease (OR = 1.32, 95% CI = 1.05-1.65, p = 0.01).
Why it matters
This Mendelian randomization study found that certain drugs, including antithrombotic agents, HMG CoA reductase inhibitors, and salicylic acid derivatives, were associated with increased risk of dementia with Lewy bodies, and HMG CoA reductase inhibitors with increased Alzheimer's disease dementia risk. The authors note that several associations had relatively low statistical power and should be interpreted with caution, so these findings do not establish that these drugs cause dementia.
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Synthesis of the results identified three overarching key principles and seven actionable practices for consideration when designing or delivering dementia education to the rural and remote health and aged care workforce.
Why it matters
This work developed the first Rural and Remote Dementia Training Framework, identifying three key principles and seven actionable practices for dementia education for the rural and remote health and aged care workforce in Australia. It offers a practical guide for employers, training providers, and professional organizations to design, deliver, and evaluate training programs.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cardiometabolic multimorbidity, lifestyle behaviours, and cognitive function: a multicohort study
- Association between chronic illnesses in older adults and caregiver burden: a cross sectional study in the United States
- Systemic inflammation and delirium: important co-factors in the progression of dementia
- Fall risk factors in older people with dementia or cognitive impairment: a systematic review
- The worldwide challenge of the dementias: a role for B vitamins and homocysteine?
- Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study
- Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
- The epidemiology of frontotemporal dementia
- Perspectives on depression, mild cognitive impairment, and cognitive decline
- Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses