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60/100

✓ Peer-reviewed alzhub usefulness score 60 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

The relationship between mild behavioral impairment (MBI) and Alzheimer's disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer's disease Neuroimaging Initiative (ADNI).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Sun, Y., Xu, W., Chen, K. L., Shen, X. N., Tan, L., Yu, J. T., et al. (2021). Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology. Translational psychiatry. https://doi.org/10.1038/s41398-021-01675-2

Vancouver

Sun Y, Xu W, Chen KL, Shen XN, Tan L, Yu JT, et al. Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology. Translational psychiatry. 2021. doi:10.1038/s41398-021-01675-2. PMID: 34759274.

BibTeX

@article{sun2021-34759274,
  author  = {Sun, Y. and Xu, W. and Chen, K. L. and Shen, X. N. and Tan, L. and Yu, J. T. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology}},
  journal = {Translational psychiatry},
  year    = {2021},
  doi     = {10.1038/s41398-021-01675-2},
  pmid    = {34759274},
  url     = {https://doi.org/10.1038/s41398-021-01675-2}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments.
We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer's disease Neuroimaging Initiative (ADNI).
We assess the longitudinal neuropathological and clinical correlates of baseline MBI via linear mixed effects and Cox proportional hazard models.
The mediation analyses were used to test the mediation effects of AD pathologies on cognition.

Why it matters

This study looked at whether amyloid plaques in the brain help explain the link between mild behavioral impairment and cognitive problems in older adults without dementia. It suggests amyloid may play a mediating role, but it does not test any treatment or show that treating amyloid improves behavior or thinking.

Study details

Study designlongitudinal study
Participants1,129
Effect size49.86%; 40.86%; HR = 2.42
Evidence strengthModerate

How this study scored 60/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 58 of the 96 points we could judge it on, which is 60 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Translational psychiatry)
Journal's citation record	2 / 4	Translational Psychiatry: journal h-index 180 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2021 — within 6 year(s) of the newest study here
Sample size	3 / 4	1,129 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 36 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.1 citations a year over 7 year(s) since 2021
Impact for its field and year	2 / 6	Cited 2.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	2 / 4	Cited 26 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	1 / 3	Fudan University: institution h-index 954 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 7 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 34759274)
Free to read	2 / 2	Free to read
Points	58 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 58 of the 96 points we could judge it on is 60 out of 100.
Total	60 / 100	—

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