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Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals
Adlin Pinheiro, Hugo Javier Aparicio, Vasileios‐Arsenios Lioutas, Alexa S. Beiser, Oluchi Stella Ekenze, Charles S DeCarli, Sudha S. Seshadri, Serkalem Demissie et al.. Journal of the American Heart Association, 2025-11-06
Topic: Risk, prevention and care in population studies
Among 1154 participants (46% men, mean age 70.9±8.7 years), 92 (8%) developed stroke over a median follow-up of 8.6 years (Q1-Q3: 5.1-12.5). In models adjusting for age, sex, time interval between clinic exam and magnetic resonance imaging, Framingham cohort, and FSRP, those with ≥3 markers had increased risk of stroke (hazard ratio [HR], 2.62 [95% CI, 1.17-5.88]). In comparison, a 5% increase in FSRP was also associated with increased risk (adjusted HR, 1.16 [95% CI, 1.04-1.29]). The FSRP and CSVD score had similar model discrimination metrics. Higher CSVD burden is associated with increased risk of stroke, beyond the effect explained by risk factors in the FSRP. These findings support consideration of CSVD burden to identify risk of stroke in community-dwelling individuals for early implementation of preventive strategies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Pinheiro, A., Aparicio, H. J., Lioutas, V., Beiser, A. S., Ekenze, O. S., DeCarli, C. S., et al. (2025). Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals. Journal of the American Heart Association. https://doi.org/10.1161/jaha.124.040263
Vancouver
Pinheiro A, Aparicio HJ, Lioutas V, Beiser AS, Ekenze OS, DeCarli CS, et al. Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals. Journal of the American Heart Association. 2025. doi:10.1161/jaha.124.040263. PMID: 41195792.
BibTeX
@article{pinheiro2025-41195792,
author = {Pinheiro, Adlin and Aparicio, Hugo Javier and Lioutas, Vasileios‐Arsenios and Beiser, Alexa S. and Ekenze, Oluchi Stella and DeCarli, Charles S and Seshadri, Sudha S. and Demissie, Serkalem and others},
title = {{Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals}},
journal = {Journal of the American Heart Association},
year = {2025},
doi = {10.1161/jaha.124.040263},
pmid = {41195792},
url = {https://doi.org/10.1161/jaha.124.040263}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Among 1154 participants (46% men, mean age 70.9±8.7 years), 92 (8%) developed stroke over a median follow-up of 8.6 years (Q1-Q3: 5.1-12.5).
- In models adjusting for age, sex, time interval between clinic exam and magnetic resonance imaging, Framingham cohort, and FSRP, those with ≥3 markers had increased risk of stroke (hazard ratio [HR], 2.62 [95% CI, 1.17-5.88]).
- In comparison, a 5% increase in FSRP was also associated with increased risk (adjusted HR, 1.16 [95% CI, 1.04-1.29]).
- The FSRP and CSVD score had similar model discrimination metrics.
- Higher CSVD burden is associated with increased risk of stroke, beyond the effect explained by risk factors in the FSRP.
Why it matters
In 1154 community-dwelling people followed for a median of 8.6 years, having three or more markers of small vessel disease was linked to a higher risk of stroke. This supports using small vessel disease burden to identify people for preventive strategies, but it does not test a specific treatment for Alzheimer's disease.
Study details
- Participants1,154
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Heart Association) |
| Journal's citation record | 2 / 4 | Journal of the American Heart Association: journal h-index 200 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,154 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jose Rafael Romero: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Boston University: institution h-index 1,456 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41195792) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1161/jaha.124.040263
- PubMed: 41195792
- Original source →
- Free full text: Journal of the American Heart Association →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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