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Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology
Haixu Chen, Lianlin Zeng. Medicine, 2025-02-21
Topic: Risk, prevention and care in population studies
The results of the inverse variance weighted analysis demonstrate a significant positive causal relationship between stroke and VaD (OR = 2.06, 95% confidence interval [CI] = 1.17-3.61, P = .01). Conversely, no evidence suggests that VaD increases the risk of stroke. Network pharmacology analysis reveals a total of 222 common targets shared by both conditions, with particular emphasis on peptide tyrosine phosphorylation pathways, including those associated with resistance to EGFR tyrosine kinase inhibitors and the AGE-RAGE signaling pathway. Our MR analysis is based on available summary statistics from genome-wide association studies to support a causal relationship between stroke and VaD. Stroke may contribute to VaD through peptide tyrosine phosphorylation-related biological processes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, H., & Zeng, L. (2025). Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology. Medicine. https://doi.org/10.1097/md.0000000000041686
Vancouver
Chen H, Zeng L. Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology. Medicine. 2025. doi:10.1097/md.0000000000041686. PMID: 39993085.
BibTeX
@article{chen2025-39993085,
author = {Chen, Haixu and Zeng, Lianlin},
title = {{Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology}},
journal = {Medicine},
year = {2025},
doi = {10.1097/md.0000000000041686},
pmid = {39993085},
url = {https://doi.org/10.1097/md.0000000000041686}
}
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Key findings
- The results of the inverse variance weighted analysis demonstrate a significant positive causal relationship between stroke and VaD (OR = 2.06, 95% confidence interval [CI] = 1.17-3.61, P = .01).
- Conversely, no evidence suggests that VaD increases the risk of stroke.
- Network pharmacology analysis reveals a total of 222 common targets shared by both conditions, with particular emphasis on peptide tyrosine phosphorylation pathways, including those associated with resistance to EGFR tyrosine kinase inhibitors and the AGE-RAGE signaling pathway.
- Our MR analysis is based on available summary statistics from genome-wide association studies to support a causal relationship between stroke and VaD.
- Stroke may contribute to VaD through peptide tyrosine phosphorylation-related biological processes.
Why it matters
Using genetic analysis, this study found evidence that stroke may causally raise the risk of vascular dementia, but found no evidence that vascular dementia raises stroke risk. It also identified shared biological targets between the two conditions, pointing to possible mechanisms but not yet to a treatment.
Study details
- Participants222
- Effect sizeOR = 2.06
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicine) |
| Journal's citation record | 3 / 4 | Medicine: journal h-index 285 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 222 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Lianlin Zeng: h-index 7 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Sichuan Vocational College of Health and Rehabilitation: institution h-index 33 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39993085) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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