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Serum albumin combined with mFI-5 for predicting postoperative delirium in elderly patients with hip fracture
Wei Wang, Rongguang Ao, Xiaokai Li, Xinyu Cao, Wenbo Sheng. Microchemical Journal, 2025-12-16
Topic: Brain proteins, microglia and lab models
The application of electrochemical sensors in medical testing is becoming increasingly widespread. Their high sensitivity, rapid response and portability make them important tools for clinical diagnosis and disease monitoring. In recent years, electrochemical sensors have made remarkable progress in the detection of biomarkers, drug concentrations, pathogens, etc. In elderly patients with hip fractures, the occurrence of postoperative delirium is related to a variety of physiological and biochemical factors, and electrochemical sensors have potential application value in detecting these factors. Hip fractures are common and serious injuries among the elderly. Due to their high incidence, high disability rate and high mortality rate, postoperative delirium is a common acute brain dysfunction, characterized by sharp fluctuations in attention, consciousness and cognitive function. Among elderly patients with hip fractures, the incidence rate is relatively high. It not only prolongs hospital stays and increases medical expenses, but is also closely related to poor functional recovery, long-term cognitive decline, increased risk of dementia and rising mortality. To explore the predictive efficacy of preoperative serum albumin combined with five modified frailty index (mFI-5) scores for postoperative delirium in elderly patients with hip fractures, and to explore the application potential of electrochemical sensors in detecting related biomarkers. The preoperative albumin levels and postoperative oxygenation status data detected by electrochemical sensors provide important support for the prediction of postoperative delirium, and their rapid and accurate detection capabilities are conducive to the early identification of high-risk patients. Therefore, preoperative albumin and mFI-5 score have a significant impact on the occurrence of postoperative delirium in elderly patients with hip fractures, and the combination of the two can improve the predictive efficacy. Electrochemical sensors perform well in detecting related biomarkers, and their application provides new ideas and tools for the early warning and precise prevention and control of postoperative delirium.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wang, W., Ao, R., Li, X., Cao, X., & Sheng, W. (2025). Serum albumin combined with mFI-5 for predicting postoperative delirium in elderly patients with hip fracture. Microchemical Journal. https://doi.org/10.1016/j.microc.2025.116607
Vancouver
Wang W, Ao R, Li X, Cao X, Sheng W. Serum albumin combined with mFI-5 for predicting postoperative delirium in elderly patients with hip fracture. Microchemical Journal. 2025. doi:10.1016/j.microc.2025.116607.
BibTeX
@article{wang2025-f75ced1e,
author = {Wang, Wei and Ao, Rongguang and Li, Xiaokai and Cao, Xinyu and Sheng, Wenbo},
title = {{Serum albumin combined with mFI-5 for predicting postoperative delirium in elderly patients with hip fracture}},
journal = {Microchemical Journal},
year = {2025},
doi = {10.1016/j.microc.2025.116607},
url = {https://doi.org/10.1016/j.microc.2025.116607}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- It not only prolongs hospital stays and increases medical expenses, but is also closely related to poor functional recovery, long-term cognitive decline, increased risk of dementia and rising mortality.
- Therefore, preoperative albumin and mFI-5 score have a significant impact on the occurrence of postoperative delirium in elderly patients with hip fractures, and the combination of the two can improve the predictive efficacy.
Why it matters
This study explores whether combining preoperative serum albumin with the mFI-5 frailty score can predict postoperative delirium in elderly hip fracture patients. It concerns prediction of a complication, not treatment, cure, or prevention of Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 31/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 29 of the 93 points we could judge it on, which is 31 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Microchemical Journal) |
| Journal's citation record | 2 / 4 | Microchemical Journal: journal h-index 154 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Wenbo Sheng holds only 5 work(s), too few to judge a track record — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 29 of the 93 points we could judge it on is 31 out of 100. |
| Total | 31 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Also tagged “delirium”
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