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Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR)
Trivedi M, Chirravuri R, Schwedt TJ, Ischii R, Dumkrieger G, Dodick D, Gottschalk CH, Tepper SJ et al.. Research Square, 2026-10-18
Topic: Brain imaging, connectivity and assessment
Results Among 1,231 patients (87.2% women; mean age 46.0 ± 13.7 years; 71.5% chronic migraine), 1,175/1,231 (95.5%) endorsed cognitive symptoms, with a mean Mig-SCog total score of 8.2 ± 4.8. In multivariable regression, migraine frequency classification was not independently associated with cognitive impairment. Women reported significantly greater cognitive impairment than men across all domains (8.4 ± 4.8 vs. 6.8 ± 4.7; p < 0.001, small effect). Word-finding difficulty demonstrated the largest ictal symptom-frequency association, with scores rising from 3.3 ± 2.6 among those never reporting word-finding difficulty to 13.6 ± 3.6 among those always reporting it (adjusted p < 0.001, large effect). In phase-based analyses, word-finding difficulty and impaired concentration were associated with 4.6- and 3.7-point higher cognitive impairment scores than in patients who did not report these symptoms during the prodrome and 5.1- and 4.0-point higher scores during the postdrome, respectively (all p < 0.001, large effects). Among patients with chronic migraine and available disease duration data (n = 661), cognitive burden was lower among those within the first 12 months of chronicity compared with those with longer-standing chronic migraine (7.7 ± 4.9 vs. 9.0 ± 4.6; p = 0.010, d = 0.27).
Key findings
- Results Among 1,231 patients (87.2% women; mean age 46.0 ± 13.7 years; 71.5% chronic migraine), 1,175/1,231 (95.5%) endorsed cognitive symptoms, with a mean Mig-SCog total score of 8.2 ± 4.8.
- In multivariable regression, migraine frequency classification was not independently associated with cognitive impairment.
- Women reported significantly greater cognitive impairment than men across all domains (8.4 ± 4.8 vs. 6.8 ± 4.7; p < 0.001, small effect).
- Word-finding difficulty demonstrated the largest ictal symptom-frequency association, with scores rising from 3.3 ± 2.6 among those never reporting word-finding difficulty to 13.6 ± 3.6 among those always reporting it (adjusted p < 0.001, large effect).
- In phase-based analyses, word-finding difficulty and impaired concentration were associated with 4.6- and 3.7-point higher cognitive impairment scores than in patients who did not report these symptoms during the prodrome and 5.1- and 4.0-point higher scores during the postdrome, respectively (all p < 0.001, large effects).
Study details
- Study designcross-sectional
- Participants661
- Effect size87.2%; 71.5%; 95.5%
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 42 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 26 of the 62 points we could judge it on, which is 42 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 661 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 26 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 26 of the 62 points we could judge it on is 42 out of 100. |
| Total | 42 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Trivedi, M., Chirravuri, R., Schwedt, T. J., Ischii, R., Dumkrieger, G., Dodick, D., et al. (2026). Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR). Research Square. https://doi.org/10.21203/rs.3.rs-11118845/v1
Vancouver
Trivedi M, Chirravuri R, Schwedt TJ, Ischii R, Dumkrieger G, Dodick D, et al. Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR). Research Square. 2026. doi:10.21203/rs.3.rs-11118845/v1.
BibTeX
@article{trivedi2026-9a7ee369,
author = {Trivedi, M. and Chirravuri, R. and Schwedt, T. J. and Ischii, R. and Dumkrieger, G. and Dodick, D. and Gottschalk, C. H. and Tepper, S. J. and others},
title = {{Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR)}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-11118845/v1},
url = {https://doi.org/10.21203/rs.3.rs-11118845/v1}
}
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