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Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia
Gonzalez AI, Tristão-Pereira C, Martinez L, Ramirez NJ, Silva GA, Alcina J, Martinez JE, Giudicessi A et al.. medRxiv, 2026-10-19
Topic: Brain imaging, connectivity and assessment
Introduction Cognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals. Methods Sixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome. Results Higher mean performance was associated with greater hippocampal volume ( β =0.24, p =.03), while memory IIV was not ( β =0.028, p =.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ( β =-0.34, p <.01), while mean performance was not ( β =-0.07, p =.52). Discussion Memory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.
Key findings
- Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy.
- Results Higher mean performance was associated with greater hippocampal volume ( β =0.24, p =.03), while memory IIV was not ( β =0.028, p =.84).
- Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ( β =-0.34, p <.01), while mean performance was not ( β =-0.07, p =.52).
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Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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APA 7th
Gonzalez, A. I., Tristão-Pereira, C., Martinez, L., Ramirez, N. J., Silva, G. A., Alcina, J., et al. (2026). Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia. medRxiv. https://doi.org/10.64898/2026.10.15.26365658
Vancouver
Gonzalez AI, Tristão-Pereira C, Martinez L, Ramirez NJ, Silva GA, Alcina J, et al. Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia. medRxiv. 2026. doi:10.64898/2026.10.15.26365658.
BibTeX
@article{gonzalez2026-ac416493,
author = {Gonzalez, A. I. and Tristão-Pereira, C. and Martinez, L. and Ramirez, N. J. and Silva, G. A. and Alcina, J. and Martinez, J. E. and Giudicessi, A. and others},
title = {{Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia}},
journal = {medRxiv},
year = {2026},
doi = {10.64898/2026.10.15.26365658},
url = {https://doi.org/10.64898/2026.10.15.26365658}
}