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Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain
Shoubridge AP, Manning SK, Tan S, Kidson S, Richard A, Trinder J, Miller S, Laver K et al.. medRxiv, 2026-10-19
Topic: Gut, metabolism and diet
INTRODUCTION Alzheimer’s disease (AD) begins with cerebral amyloid-beta (AP) deposition decades before clinical symptoms. While the microbiota–gut–brain axis has been implicated in AD, its role in this preclinical phase remains unclear. We examined potential links between gut microbiome features and presymptomatic cerebral Ap burden. METHODS Asymptomatic individuals (n=101, median age 70.0 years, 53% female) underwent cognitive assessment, cerebral Ap quantification, and stool metagenomic sequencing. Associations between microbial characteristics and Ap levels were performed using multivariable-adjusted ordinal logistic regression. RESULTS Gut microbiota composition varied with Ap levels (p(perm)=0.03, R 2 =0.014). Higher Ap was associated with increased Alistipes communis, and decreased Anaerotignum faecicola and Eubacterium rectale, abundance (q<0.001). Ap-associated microbiome traits corresponded to lower biosynthetic capacity for y-aminobutyric acid, and systemic regulators of immunity and autophagy (q<0.01). DISCUSSION Early Ap accumulation is associated with distinct gut microbial signatures and reduced neuroactive metabolic potential, identifying targets for potential preclinical AD intervention.
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APA 7th
Shoubridge, A. P., Manning, S. K., Tan, S., Kidson, S., Richard, A., Trinder, J., et al. (2026). Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain. medRxiv. https://doi.org/10.64898/2026.10.15.26365677
Vancouver
Shoubridge AP, Manning SK, Tan S, Kidson S, Richard A, Trinder J, et al. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain. medRxiv. 2026. doi:10.64898/2026.10.15.26365677.
BibTeX
@article{shoubridge2026-ae56d04b,
author = {Shoubridge, A. P. and Manning, S. K. and Tan, S. and Kidson, S. and Richard, A. and Trinder, J. and Miller, S. and Laver, K. and others},
title = {{Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain}},
journal = {medRxiv},
year = {2026},
doi = {10.64898/2026.10.15.26365677},
url = {https://doi.org/10.64898/2026.10.15.26365677}
}
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Key findings
- RESULTS Gut microbiota composition varied with Ap levels (p(perm)=0.03, R 2 =0.014).
- Higher Ap was associated with increased Alistipes communis, and decreased Anaerotignum faecicola and Eubacterium rectale, abundance (q<0.001).
- DISCUSSION Early Ap accumulation is associated with distinct gut microbial signatures and reduced neuroactive metabolic potential, identifying targets for potential preclinical AD intervention.
Study details
- Participants101
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 29 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 18 of the 62 points we could judge it on, which is 29 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 101 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 18 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 18 of the 62 points we could judge it on is 29 out of 100. |
| Total | 29 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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