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Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials
Michael D. Flanders, Michelle Caunca, Renaud La Joie, Lon S. S. Schneider, Sarah F. Ackley. JAMA Neurology, 2026-05-18
Topic: Amyloid, tau and blood-test diagnosis
This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.
Key findings
- This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.
Why it matters
This study looks at a statistical method for combining results in Alzheimer disease trials, using simulated data and existing trial data. It does not test any treatment in patients, so it does not show whether any therapy works.
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Study details
- Study designrandomized controlled trial
- Evidence strengthHigh
How this study scored 58/100
Published in a leading specialty journal, and it is a randomised controlled trial. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sarah F. Ackley: h-index 22 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42149605) |
| Free to read | 2 / 2 | Free to read |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2026.1240
- PubMed: 42149605
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Flanders, M. D., Caunca, M., La Joie, R., Schneider, L. S. S., & Ackley, S. F. (2026). Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2026.1240
Vancouver
Flanders MD, Caunca M, La Joie R, Schneider LSS, Ackley SF. Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials. JAMA Neurology. 2026. doi:10.1001/jamaneurol.2026.1240. PMID: 42149605.
BibTeX
@article{flanders2026-42149605,
author = {Flanders, Michael D. and Caunca, Michelle and La Joie, Renaud and Schneider, Lon S. S. and Ackley, Sarah F.},
title = {{Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials}},
journal = {JAMA Neurology},
year = {2026},
doi = {10.1001/jamaneurol.2026.1240},
pmid = {42149605},
url = {https://doi.org/10.1001/jamaneurol.2026.1240}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.