Home › Research › Risk factors
Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis
Inas Youssef Younis, Mohamed S. Sedeek, Ahmed F. Essa, Abdelbaset M. Elgamal, Basma Mohamed Eltanany, Zeinab M. Goda, Laura Pont, Fernando Benavente et al.. Food Chemistry, 2024-11-05
Topic: Amyloid, tau and blood-test diagnosis
Quinoa is an ancient Andean crop with a significant interest due to its nutritional and health benefits. This work provides a comprehensive metabolite profiling of five commercially available quinoa grains from diverse geographical origins. GC-MS analysis of primary metabolites identified sugars, sugar derivatives, and lipids as the predominant classes. LC-QTOF-MS/MS metabolomics and molecular networking facilitated the identification of 151 secondary metabolites, including 20 flavonoids, 14 saponins, and 20 lipids, which were reported for the first time in quinoa. In the AChE inhibition assay, USA white quinoa exhibited the highest activity. Chemometric analyses indicated that flavonoids and saponins were crucial for distinguishing quinoa grains. Notably, flavonoid glycosides and saponins were positively correlated with AChE inhibition. This study represents the first MS-based metabolomics investigation using molecular networking and chemometrics to explore the metabolome heterogeneity of commercial quinoa grains, underscoring their potential as a promising natural source for combating Alzheimer's disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Younis, I. Y., Sedeek, M. S., Essa, A. F., Elgamal, A. M., Eltanany, B. M., Goda, Z. M., et al. (2024). Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis. Food Chemistry. https://doi.org/10.1016/j.foodchem.2024.141918
Vancouver
Younis IY, Sedeek MS, Essa AF, Elgamal AM, Eltanany BM, Goda ZM, et al. Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis. Food Chemistry. 2024. doi:10.1016/j.foodchem.2024.141918. PMID: 39541691.
BibTeX
@article{younis2024-39541691,
author = {Younis, Inas Youssef and Sedeek, Mohamed S. and Essa, Ahmed F. and Elgamal, Abdelbaset M. and Eltanany, Basma Mohamed and Goda, Zeinab M. and Pont, Laura and Benavente, Fernando and others},
title = {{Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis}},
journal = {Food Chemistry},
year = {2024},
doi = {10.1016/j.foodchem.2024.141918},
pmid = {39541691},
url = {https://doi.org/10.1016/j.foodchem.2024.141918}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Quinoa is an ancient Andean crop with a significant interest due to its nutritional and health benefits.
- Chemometric analyses indicated that flavonoids and saponins were crucial for distinguishing quinoa grains.
Why it matters
This laboratory study analyzed chemicals in quinoa grains and found that certain compounds were associated with inhibition of an enzyme called AChE. This is early, preliminary work and does not show that quinoa or its compounds can treat, cure, or prevent Alzheimer's disease in people.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Food Chemistry) |
| Journal's citation record | 3 / 4 | Food Chemistry: journal h-index 399 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 17 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.2 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 3 / 6 | Cited 3.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Engy Mohsen: h-index 14 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Universitat de Barcelona: institution h-index 1,049 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39541691) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.foodchem.2024.141918
- PubMed: 39541691
- Original source →
- Free full text: Food Chemistry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Risk factors
Also tagged “amyloid-beta”
1,339 studies in the library carry the topic tag “amyloid-beta”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,339 tagged studies.