Home › Research › Risk factors
Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study
Dong Chen, Yu Long, Yudiyang Ma, Weihong Sha, Lijun Zhang, Yuying Ma, Qinming Li, Jing Feng et al.. Journal of the American Heart Association, 2025-05-02
Topic: Air pollution and environmental exposures
Plain-language summary
Over 13 years, 65 336 patients with FCMD were identified, with 2584 developing dementia and 10 664 dying. Each interquartile range increase in pollutant concentrations showed the hazard ratios (HRs) of particulate matter with aerodynamic diameter ≤2.5 μm (HR, 1.03 [95% CI, 1.02-1.05]); nitrogen dioxide (HR, 1.04 [95% CI, 1.03-1.05]), and nitrogen oxides (HR, 1.03 [95% CI, 1.02-1.04]) for transitioning from baseline to FCMD; particulate matter with aerodynamic diameter ≤2.5 μm (HR, 1.11 [95% CI, 1.05-1.16]; nitrogen dioxide: HR, 1.12 [95% CI, 1.06-1.18]; and nitrogen oxides (HR, 1.07 [95% CI, 1.03-1.12]) for transitioning from FCMD to dementia, and the association between pollutants and this trajectory remained consistent after adjusting for genetic susceptibility to dementia (particulate matter with aerodynamic diameter ≤2.5 μm: HR, 1.06 [95% CI, 1.04-1.08]; nitrogen dioxide: HR, 1.05 ([95% CI, 1.03-1.07); and nitrogen oxides: HR, 1.05 [95% CI, 1.03-1.06]) for transitioning from baseline to death; and particulate matter with aerodynamic diameter ≤2.5 μm: HR, 1.03 ([95% CI, 1.00-1.05); nitrogen dioxide: HR, 1.05 ([95% CI, 1.02-1.08); nitrogen oxides: HR, 1.04 ([95% CI, 1.01-1.06]) for transitioning from subsequent FCMD to death. Particulate matter with aerodynamic diameter ≤10 μm was only significantly associated with the transition from baseline to FCMD. Our study provides the first evidence that atmospheric pollutants are associated with the progression of FCMD and subsequent dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, D., Long, Y., Ma, Y., Sha, W., Zhang, L., Ma, Y., et al. (2025). Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study. Journal of the American Heart Association. https://doi.org/10.1161/jaha.124.040844
Vancouver
Chen D, Long Y, Ma Y, Sha W, Zhang L, Ma Y, et al. Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study. Journal of the American Heart Association. 2025. doi:10.1161/jaha.124.040844. PMID: 40314379.
BibTeX
@article{chen2025-40314379,
author = {Chen, Dong and Long, Yu and Ma, Yudiyang and Sha, Weihong and Zhang, Lijun and Ma, Yuying and Li, Qinming and Feng, Jing and others},
title = {{Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study}},
journal = {Journal of the American Heart Association},
year = {2025},
doi = {10.1161/jaha.124.040844},
pmid = {40314379},
url = {https://doi.org/10.1161/jaha.124.040844}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Over 13 years, 65 336 patients with FCMD were identified, with 2584 developing dementia and 10 664 dying.
- Each interquartile range increase in pollutant concentrations showed the hazard ratios (HRs) of particulate matter with aerodynamic diameter ≤2.5 μm (HR, 1.03 [95% CI, 1.02-1.05]); nitrogen dioxide (HR, 1.04 [95% CI, 1.03-1.05]), and nitrogen oxides (HR, 1.03 [95% CI, 1.02-1.04]) for transitioning from baseline to FCMD; particulate matter with aerodynamic diameter ≤2.5 μm (HR, 1.11 [95% CI, 1.05-1.16]; nitrogen dioxide: HR, 1.12 [95% CI, 1.06-1.18]; and nitrogen oxides (HR, 1.07 [95% CI, 1.03-1.12]) for transitioning from FCMD to dementia, and the association between pollutants and this trajectory remained consistent after adjusting for genetic susceptibility to dementia (particulate matter with aerodynamic diameter ≤2.5 μm: HR, 1.06 [95% CI, 1.04-1.08]; nitrogen dioxide: HR, 1.05 ([95% CI, 1.03-1.07); and nitrogen oxides: HR, 1.05 [95% CI, 1.03-1.06]) for transitioning from baseline to death; and particulate matter with aerodynamic diameter ≤2.5 μm: HR, 1.03 ([95% CI, 1.00-1.05); nitrogen dioxide: HR, 1.05 ([95% CI, 1.02-1.08); nitrogen oxides: HR, 1.04 ([95% CI, 1.01-1.06]) for transitioning from subsequent FCMD to death.
- Particulate matter with aerodynamic diameter ≤10 μm was only significantly associated with the transition from baseline to FCMD.
- Our study provides the first evidence that atmospheric pollutants are associated with the progression of FCMD and subsequent dementia.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Participants149
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Heart Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 149 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40314379) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Risk factors from nearby years
Also tagged “air”
237 studies in the library carry the topic tag “air”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 237 tagged studies.