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ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years
Maria Anabel Uehara, Sumeet Kalia, Mari T. Garcia Campuzano, Zahra Moussavi. Medicina, 2025-11-06
Topic: Risk, prevention and care in population studies
Participants showed a significantly slower rate of cognitive decline than expected from the AD reference rate (p < 0.001), with many demonstrating stabilized ADAS-Cog scores during their respective treatment periods, ranging from 1 to 3 years. Medication analyses revealed no significant effect of AD medications, antidepressants, antihypertensives, or cholesterol-lowering agents on cognitive outcomes. Furthermore, longer no-treatment intervals were significantly associated with greater post-treatment decline (p < 0.001). Repeated non-invasive treatments seem to slow the rate of cognitive decline in individuals living with dementia when administered over a prolonged period. This study provides evidence supporting the feasibility and effects of personalized long-term non-invasive treatment strategies for dementia.
Key findings
- Participants showed a significantly slower rate of cognitive decline than expected from the AD reference rate (p < 0.001), with many demonstrating stabilized ADAS-Cog scores during their respective treatment periods, ranging from 1 to 3 years.
- Medication analyses revealed no significant effect of AD medications, antidepressants, antihypertensives, or cholesterol-lowering agents on cognitive outcomes.
- Furthermore, longer no-treatment intervals were significantly associated with greater post-treatment decline (p < 0.001).
- Repeated non-invasive treatments seem to slow the rate of cognitive decline in individuals living with dementia when administered over a prolonged period.
- This study provides evidence supporting the feasibility and effects of personalized long-term non-invasive treatment strategies for dementia.
Why it matters
In this study, people with dementia who received repeated non-invasive treatments over one to three years declined more slowly than expected, and longer gaps without treatment were linked to greater decline afterward. The study reports no significant effect of Alzheimer's medications, antidepressants, antihypertensives or cholesterol-lowering agents on cognitive outcomes.
Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 50/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicina) |
| Journal's citation record | 1 / 4 | Medicina: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Zahra Moussavi: h-index 35 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Manitoba: institution h-index 666 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41303831) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Uehara, M. A., Kalia, S., Campuzano, M. T. G., & Moussavi, Z. (2025). ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years. Medicina. https://doi.org/10.3390/medicina61111994
Vancouver
Uehara MA, Kalia S, Campuzano MTG, Moussavi Z. ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years. Medicina. 2025. doi:10.3390/medicina61111994. PMID: 41303831.
BibTeX
@article{uehara2025-41303831,
author = {Uehara, Maria Anabel and Kalia, Sumeet and Campuzano, Mari T. Garcia and Moussavi, Zahra},
title = {{ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years}},
journal = {Medicina},
year = {2025},
doi = {10.3390/medicina61111994},
pmid = {41303831},
url = {https://doi.org/10.3390/medicina61111994}
}
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