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Neurologic aspects of cobalamin deficiency
Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J.. Medicine, 1991-07-01
Topic: Brain proteins, microglia and lab models
In addition, the hematocrit correlated significantly with severity, independent of the longer duration of symptoms in nonanemic patients.
Key findings
- In addition, the hematocrit correlated significantly with severity, independent of the longer duration of symptoms in nonanemic patients.
Why it matters
This paper reports that the hematocrit correlated significantly with severity of neurologic aspects of cobalamin deficiency, independent of the longer duration of symptoms in nonanemic patients. No information on treating, curing, or preventing Alzheimer's disease is provided in the available text.
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Study details
- Participants143
- Effect size27.4%; 23.0%; 47.1%
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicine) |
| Journal's citation record | 3 / 4 | Medicine: journal h-index 285 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1991 — older than 20 years, still counted |
| Sample size | 2 / 4 | 143 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 780 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.1 citations a year over 37 year(s) since 1991 |
| Impact for its field and year | 3 / 6 | Cited 7.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 3 / 4 | Cited 62 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author John Lindenbaum: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1648656) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Healton, E. B., Savage, D. G., Brust, J. C., Garrett, T. J., & Lindenbaum, J. (1991). Neurologic aspects of cobalamin deficiency. Medicine. https://doi.org/10.1097/00005792-199107000-00001
Vancouver
Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine. 1991. doi:10.1097/00005792-199107000-00001. PMID: 1648656.
BibTeX
@article{healton1991-1648656,
author = {Healton, E. B. and Savage, D. G. and Brust, J. C. and Garrett, T. J. and Lindenbaum, J.},
title = {{Neurologic aspects of cobalamin deficiency}},
journal = {Medicine},
year = {1991},
doi = {10.1097/00005792-199107000-00001},
pmid = {1648656},
url = {https://doi.org/10.1097/00005792-199107000-00001}
}
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