Home › Research › Topics › lithium
lithium
139 studies tagged lithium, dated 1972-06-01 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder 2026-10-16
- Newly diagnosed postoperative depression and incident dementia after major surgery: a Korean nationwide retrospective cohort study 2026-09-30
- Brain Iron Accumulation and Its Cognitive and Olfactory Correlates in Late-Life Depression 2026-09-10
Studies
139 studies carry this tag.
Date range
1972 to 2026
Top journals
- Journal of affective disorders 6
- The British journal of psychiatry : the journal of mental science 6
- International journal of geriatric psychiatry 5
- Journal of Alzheimer's disease : JAD 4
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 4
94 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
-
Cortisol is primarily synthesized by the adrenal glands, but also within specific tissues via a distinct enzymatic pathway. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the synthesis of cortisol within cells to create local higher cortisol environments in those organs where it is highly expressed such as the liver and brain.
-
Newly diagnosed postoperative depression was associated with increased dementia risk, particularly in patients aged < 65 years, supporting prospective evaluation as a potential marker of long-term cognitive risk.
-
Late-life depression (LLD) is associated with cognitive impairment, olfactory dysfunction and dementia risk, while brain iron accumulation has been linked to depressive symptoms, cognitive impairment and Alzheimer’s disease progression.
-
Forty-eight studies, mostly of weak- or moderate-quality, met inclusion criteria.
-
These estimates are planning values for populations resembling the contributing studies, not national population rates.
-
Apathy and depression are among the most common neuropsychiatric symptoms in dementia.
-
Lifetime TBI exposure is associated with increased likelihood and long-term risk of psychiatric disorders in individuals with dementia, stroke, and Parkinson’s disease, with mood disorders being the most consistent outcome across conditions.
-
Social isolation and loneliness are increasingly recognized as detrimental risk factors for brain health.
-
Overall, 81.7% of residents diagnosed with depression had ≥1 pharmacological depression treatment order.
-
Major depressive disorder (MDD) has been associated with an increased risk of cognitive decline and neurodegenerative disorders like Alzheimer's disease (AD), prompting interest in peripheral biomarkers related to amyloid metabolism as well as neuroaxonal and astroglial injury.
-
Late-life depression (LLD) is associated with cognitive decline and increased risk of dementia.
-
Recent mechanistic evidence identifies lithium deficiency as a driver of Alzheimer’s disease and related dementias (ADRD) pathogenesis.
-
In a recent open-label, single-arm study, vortioxetine, an antidepressant, was associated with improved cognitive function in patients with MCI, however, no placebo-controlled studies have been conducted to support these findings.
-
Of 8171 patients with late-life depression, 1443 (17.7 %) had TRLLD.
-
Across 3544 participants, ≥65 years of age, with no diagnosed dementia-related disorders, the depression symptom everything was an effort showed high expected influence across all time points.
-
43/100
Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease.
-
43/100
The 75th anniversary of introducing lithium into modern psychiatry is recognized, attested by the 1949 paper of John Cade.
-
While most studies to date have been cross-sectional, limiting the establishment of causal relationships, the potential benefits of trace lithium for suicide prevention and dementia prevention are notable, especially in the absence of radical treatments for suicide and dementia.
-
Cognitive dysfunction is common in late life depression (LLD) and is a major risk factor for dementia.
-
89/100
Eight studies with 377,060 subjects were included in the analysis.
-
61/100
Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005).
-
The synaptic proteins revealed no statistically significant differences between BD and HC, neither at baseline, one-year follow-up, or in terms of changes from baseline to follow-up.
-
A total of seven studies were included. The forest plot results showed that taking lithium therapy reduced the risk of AD (RR 0.59, 95% confidence interval [CI]: 0.44-0.78) and is also protective in reducing the risk of dementia (RR 0.66, 95% CI: 0.56-0.77).
-
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained.
-
Our sample had a mean age of 66.8 (SD = 5.3) years, a mean HAM-D score of 19.4 (SD = 7.5), and a mean PHQ-9 score of 18.0 (SD = 6.3).
-
43/100
Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal role in various physiological processes.
-
75/100
BDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function.
-
With the unprecedented aging of the world's population, the number of elderly patients with depression is expected to increase.
-
41/100
in multi-adjusted models, relative to individuals without depression, those with major (β per year: 0.33, 95% confidence interval [CI]: 0.06-0.61) and subsyndromal depression (β per year: 0.21, 95%CI: 0.12-0.30) experienced an accelerated rate of somatic multimorbidity accumulation, whereas those with minor depression did not.
-
In older age, frailty is a detrimental transitional status of the aging process featuring an increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves.
-
This study included 407 participants (96 Thal, 405 Braak, and 406 CERAD).
-
Higher neuroticism is a risk factor for Alzheimer's disease (AD), and is implicated in disordered stress responses.
-
Higher cognitive (HR: 0.91/SD, 95%CI: 0.84; 1.00) and brain reserve (HR: 0.88/SD, 95%CI: 0.77; 1.00) were associated with a lower risk of a depressive event after adjustment for baseline depressive symptoms.
-
The loss of olfactory stimulation correlates well with at least 68 widely differing neurological disorders, including depression, and we raise the possibility that this relationship may be causal.
-
A total of 66 patients with MDD (n = 50) and BD (n = 16) were analyzed.
-
The adjusted model showed a significant inverse association of lithium levels with female, but not with male, or total prevalence of AD.
-
41/100
The analysis revealed decreased Aβ42 levels and increased Aβ42/40 ratios in elderly patients with depression at admission compared with healthy subjects.
-
66/100
In this cohort study of data from 8.38 million adults (4.18 million women, 4.20 million men; mean [SD] age 49.18 [18.45] years); 16 679 (0.02%) survived a hospital admission for SARI, and 32 525 (0.03%) survived a hospital admission for COVID-19.
-
There was no statistically significant difference between the two groups in terms of depressive symptoms, cognitive functions, and ADL.
-
Individuals with unipolar depressive disorder (UDD) are having an increased risk of death and development of dementia in later life.
-
Currently, in psychiatry, lithium is a drug of choice as a mood stabilizer in the maintenance treatment of bipolar disorder for the prevention of manic and depressive recurrences.
-
Compared with LLD patients without OI impairment and normal controls, LLD patients with OI impairment exhibited increased FC between the left orbital frontal cortex (OFC) and left calcarine gyrus, between the left OFC and right lingual gyrus, between the right OFC and right rectus gyrus, and decreased FC between the right piriform cortex and right superior parietal lobule.
-
In the incident depression group, there was a mild decline in cognitive scores from baseline to the visit before depression onset compared with the never-depressed group.
-
LOD patients exhibited lower OI scores than EOD patients and normal controls (NCs).
-
Cognitive disorders are frequently found during late-life depression (LLD).
-
Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD.
-
This narrative review aimed to explore the existing knowledge in order to examine the multiple forms of late-life depression (LLD) within a non-neurodegenerative or a neurodegenerative context, in particular Alzheimer's disease (AD).
-
Late-life depression (LLD), compared to depression at a young age, is more likely to have poor prognosis and high risk of progression to dementia.
-
Late-life depression is frequently associated with cognitive impairment.
-
TL was significantly shorter in the LLD compared with control participants (p = .039).
From across this tag
9 of the 139 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Assessment of late life depression
- Depression and dementia
- Dementia Praecox and Paraphrenia
- Cognitive deficits in geriatric depression: clinical correlates and implications for current and future treatment
- The heterogeneity of “major depression”
- Molecular imaging of beta-amyloid deposition in late-life depression
- A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease
- Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
- Suicide as an outcome for mental disorders. A meta-analysis