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Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation
Deborah A Deliyannides, Jamie A Graff, Izael Niño, Seonjoo Lee, Mustafa M Husain, Brent P Forester, Elizabeth Crocco, Ipsit V Vahia et al.. International journal of geriatric psychiatry, 2023-09
Topic: Drug trials: efficacy and safety
BDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function. More research is needed to understand the potential effects of lithium on BDNF in AD including whether its use might be dependent on the stage of cognitive decline and dementia.
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APA 7th
Deliyannides, D. A., Graff, J. A., Niño, I., Lee, S., Husain, M. M., Forester, B. P., et al. (2023). Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.6002
Vancouver
Deliyannides DA, Graff JA, Niño I, Lee S, Husain MM, Forester BP, et al. Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation. International journal of geriatric psychiatry. 2023. doi:10.1002/gps.6002. PMID: 37732619.
BibTeX
@article{deliyannides2023-37732619,
author = {Deliyannides, Deborah A and Graff, Jamie A and Niño, Izael and Lee, Seonjoo and Husain, Mustafa M and Forester, Brent P and Crocco, Elizabeth and Vahia, Ipsit V and others},
title = {{Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation}},
journal = {International journal of geriatric psychiatry},
year = {2023},
doi = {10.1002/gps.6002},
pmid = {37732619},
url = {https://doi.org/10.1002/gps.6002}
}
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Key findings
- BDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function.
- More research is needed to understand the potential effects of lithium on BDNF in AD including whether its use might be dependent on the stage of cognitive decline and dementia.
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Study details
- Evidence strengthHigh
How this study scored 75/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size and effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 42 of the 56 points we could judge it on, which is 75 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37732619) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 42 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 42 of the 56 points we could judge it on is 75 out of 100. |
| Total | 75 / 100 | — |
What each of these 20 components measures, and what this score is not →
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