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Molecular imaging of beta-amyloid deposition in late-life depression
Gwenn S Smith, Hiroto Kuwabara, Ayon Nandi, Neda F Gould, Najilla Nassery, Alena Savonenko, Jin Hui Joo, Michael Kraut et al.. Neurobiology of aging, 2021-01-15
Topic: Plasma and spinal-fluid biomarkers
Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology. Twenty-one LLD patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a current major depressive episode and 21 healthy controls underwent clinical and neuropsychological assessments, magnetic resonance imaging to measure gray matter volumes, and high-resolution positron emission tomography to measure beta-amyloid (Aβ) deposition. Clinical and neuropsychological assessments were repeated after 10-12 weeks of Citalopram or Sertraline treatment (LLD patients only). LLD patients did not differ from healthy controls in baseline neuropsychological function, although patients improved in both depressive symptoms and visual-spatial memory during treatment. Greater Aβ in the left parietal cortex was observed in LLD patients compared with controls. Greater Aβ was correlated with greater depressive symptoms and poorer visual-spatial memory, but not with improvement with treatment. The study of LLD patients with prospective measurements of mood and cognitive responses to antidepressant treatment is an opportunity to understand early neurobiological mechanisms underlying the association between depression and subsequent cognitive decline.
Key findings
- Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology.
- Greater Aβ in the left parietal cortex was observed in LLD patients compared with controls.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33592548) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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APA 7th
Smith, G. S., Kuwabara, H., Nandi, A., Gould, N. F., Nassery, N., Savonenko, A., et al. (2021). Molecular imaging of beta-amyloid deposition in late-life depression. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2021.01.002
Vancouver
Smith GS, Kuwabara H, Nandi A, Gould NF, Nassery N, Savonenko A, et al. Molecular imaging of beta-amyloid deposition in late-life depression. Neurobiology of aging. 2021. doi:10.1016/j.neurobiolaging.2021.01.002. PMID: 33592548.
BibTeX
@article{smith2021-33592548,
author = {Smith, Gwenn S and Kuwabara, Hiroto and Nandi, Ayon and Gould, Neda F and Nassery, Najilla and Savonenko, Alena and Joo, Jin Hui and Kraut, Michael and others},
title = {{Molecular imaging of beta-amyloid deposition in late-life depression}},
journal = {Neurobiology of aging},
year = {2021},
doi = {10.1016/j.neurobiolaging.2021.01.002},
pmid = {33592548},
url = {https://doi.org/10.1016/j.neurobiolaging.2021.01.002}
}
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