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Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. The Gut-Brain Axis: Literature Overview and Psychiatric Applications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2021-08 Disease mechanisms

    Clinicians are encouraged to consider patients' gut health when evaluating and treating psychiatric conditions, such as anxiety and depression.

  2. Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Experimental brain research 2021-07-20 Drug development

    Insulin deficiency or resistance can promote dementia and hallmarks of Alzheimer's disease (AD).

  3. Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cureus 2021-07-20 Disease mechanisms

    Alzheimer's disease (AD) is the most common form of dementia and the fifth leading cause of death among the elderly.

  4. Structural Brain Changes Associated with Overweight and Obesity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of obesity 2021-07-16 Risk factors

    Obesity is a global health problem with a broad set of comorbidities, such as malnutrition, metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure.

  5. The Relationship Between the Gut Microbiome and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience bulletin 2021-07-03 Disease mechanisms

    Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology.

  6. Metabolic Syndrome: Is It Time to Add the Central Nervous System?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2021-06-30 Risk factors

    Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias.

  7. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2021-06-12 Prevention and risk

    The average life expectancy of the world population has increased remarkably in the past 150 years and it is still increasing.

  8. The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular neuroscience 2021-04-14 Disease mechanisms

    Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative disorders worldwide and poses a major challenge for both affected individuals and their caregivers.

  9. Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2021-04-01 Inflammation and the immune system

    Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive decline, is a major cause of death and disability among the older population.

  10. Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cells

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of biological research (Thessalonike, Greece) 2021-02-25 Disease mechanisms

    No significant cytotoxicity was observed at ART concentrations up to 40 μM. ART could significantly increase the viability of SH-SY5Y cells treated with MPP+ and reduce oxidative stress damage and apoptosis.

  11. High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2021-02-12 Disease mechanisms

    Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer's disease (AD).

  12. Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cell and developmental biology 2021-02-04 Disease mechanisms

    Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD).

  13. EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging 2021-02-03 Disease mechanisms

    Chronic cerebral hypoperfusion (CCH) may lead to the cognitive dysfunction, but the underlying mechanisms are unclear.

  14. Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cellular and molecular neurobiology 2021-01-05 Disease mechanisms

    Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and human health.

  15. Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Mini reviews in medicinal chemistry 2021 Prevention and risk

    The Mediterranean diet (MD) is becoming a milestone for the prevention of chronic diseases, such as cardiovascular diseases (CVDs), Alzheimer's and Parkinson's disease.

  16. The role of the microbiota-gut-brain axis in neuropsychiatric disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 2021 Disease mechanisms

    The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and the central nervous system.

  17. Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current neuropharmacology 2021 Disease mechanisms

    The human digestive system is embedded with trillions of microbes of various species and genera.

  18. The sleep and circadian problems of Huntington's disease: when, why and their importance

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neurology 2020-12-23 Risk factors

    This cycle is challenging to study, as its bidirectional nature renders cause difficult to disentangle from effect.

  19. Mitochondrial unfolded protein response: An emerging pathway in human diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Free radical biology & medicine 2020-12-21 Disease mechanisms

    Mitochondrial unfolded protein response (UPRmt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins and proteases are initiated to maintain proteostasis in mitochondria.

  20. The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in immunology 2020-12-10 Inflammation and the immune system

    The human microbiota has a fundamental role in host physiology and pathology.

  21. Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of pharmaceutical and biomedical analysis 2020-11-21 Disease mechanisms

    Gut microbiota represents a complex physiological ecosystem that influences the host health.

  22. The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain sciences 2020-11-17 Prevention trials

    The glymphatic system is a "pseudo-lymphatic" perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.

  23. Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2020-10-21 Risk factors

    Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain.

  24. Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2020-10-02 Genetics

    These data for the first time provide evidence of potential causal links between gut microbiome and AD, MDD, and SCZ.

  25. Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurobiology 2020-08-23 Disease mechanisms

    Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade.

From across this topic

9 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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