Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Alzheimer's disease (AD) is still a major public health challenge without an effective treatment to prevent or stop it.
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Currently there is no effective therapy available for cognitive impairments in Down syndrome (DS), one of the most prevalent forms of intellectual disability in humans associated with the chromosomes 21 trisomy.
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One hundred and fifty years ago, Paul Langerhans described what would come to be known as pancreatic 'islet of Langerhans'.
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This paper describes the effects of the gut microbiota on the pathogenesis of Alzheimer's pathology by evaluating the current original key findings and identifying gaps in the knowledge required for validation.
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Single-cell digital PCR revealed GLP-1 receptor expression in neurogliaform cells and showed that copy numbers of mRNA of the Glp1r gene in hyperglycaemia exceeded those in hypoglycaemia by 9.6 times (p < 0.008).
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Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD), and insulin-resistance is commonly seen in patients with Hhcy.
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39/100
Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision.
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Incretin contains two peptides named glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
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Recently, Alzheimer's disease (AD) is understood as "diabetes of the brain" or "type 3 diabetes."
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39/100
Neurodegenerative disorders are the most devastating disorder of the nervous system.
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Some observational studies have instead demonstrated that, in older individuals, frailty and Alzheimer-type dementia are associated with fecal microbiota dysbiosis, that is, reduced biodiversity and overexpression of pathobionts.
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Elevated homocysteine in the blood, or hyperhomocysteinemia, is a recognized risk factor for multiple causes of dementia including Alzheimer’s disease.
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Neuromodulation regulates critical functions of CNS synapses, ranging from neural circuit development to high-order cognitive processes, including learning and memory.
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Hearing loss has been recently ranked as the fifth leading cause of years lived with disability, ahead of many other chronic diseases such as diabetes, dementia, or chronic obstructive pulmonary disease.
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Alzheimer's disease (AD) is an increasingly common neurodegenerative disease.
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To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density.
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Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease.
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Laboratory and epidemiological data indicate that high blood sugar levels and/or consuming high glycemia diets are linked to multiple age-related diseases, including age-related macular degeneration, cataract, Parkinson's disease, Alzheimer's disease, diabetic retinopathy, and, apparently glaucoma.
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Major depressive disorder in the elderly-or late-life depression (LLD)-is one of the most common mental illnesses in the aging population.
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Obesity and diabetes are both risk factors and consequences of psychiatric disorders.
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Insulin resistance (IR), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and Alzheimer's disease.
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Cerebrospinal fluid (CSF) is a fluidic part of the brain's microenvironment that isolates the brain from the rest of the body.
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We report herein that wildtype, PSEN2 N141I and CRISPR/Cas9-corrected iPSC-derived BFCNs (and their precursors) show indistinguishable insulin signaling profiles as determined by the phosphorylation of canonical insulin signaling pathway molecules.
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39/100
Frailty, which is a syndrome that encompasses losses in physical, psychological and social domains, is responsible for enhanced vulnerability to endogenous and/or exogenous stressors.
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that develops insidiously and causes dementia finally.
From across this topic
10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- High fat diet induces brain insulin resistance and cognitive impairment in mice
- The Role of Oxidative Stress in Neurodegenerative Diseases
- The Gut-Brain Axis Mechanism in Alzheimer’s Disease: From Animal Models to Clinical Translation and Innovative Treatment Strategies
- Impact of Metabolic Syndrome on Neuroinflammation and the Blood-Brain Barrier
- The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease
- [Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?]
- Molecular Basis of Late-Life Depression
- Lipid peroxidation products and antioxidants in human disease
- Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
- Enteric nervous system and intestinal epithelial regulation of the gut-brain axis