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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. EBioMedicine 2020-08-30 Disease mechanisms

    Compared to CN counterparts, patients with MCI have higher proportion of families Sclerotiniaceae, Phaffomyceteceae, Trichocomaceae, Cystofilobasidiaceae, Togniniaceae and genera Botrytis, Kazachstania, Phaeoacremonium and Cladosporium and lower abundance of Meyerozyma.

  2. Fecal Microbiota Transplantation in Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in cellular and infection microbiology 2020-03-24 Disease mechanisms

    Of 541 identified studies, 34 were included in the analysis.

  3. The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Nutrients 2017-09-22 Disease mechanisms

    -oxide (TMAO) is a small organic molecule, derived from the intestinal and hepatic metabolism of dietary choline and carnitine.

  4. Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2023-12-01 Disease mechanisms

    Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health.

  5. Targeting immunometabolic pathways for combination therapy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia (New York, N. Y.) 2023-09-30 Treatments

    The recent success of disease-modifying anti-amyloid monoclonal antibodies in slowing Alzheimer's disease (AD) symptoms has been an exciting step forward for the field.

  6. Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2022-10-18 Drug development

    Despite an ever-growing prevalence and increasing economic burden of Alzheimer's disease (AD) and Parkinson's disease (PD), recent advances in drug development have only resulted in minimally effective treatment.

  7. Healthy Aging-Nutrition Matters: Start Early and Screen Often

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Advances in nutrition (Bethesda, Md.) 2021-07-01 Risk factors

    The amount of time spent in poor health at the end of life is increasing.

  8. Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2021-04-19 Genetics

    The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the highest level cognitive and emotional processes.

  9. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. eLife 2021-04-13 Genetics

    Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression.

  10. Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer s Disease 2021-01-29 Disease mechanisms

    Although there was no difference in the microbial α-diversity among the three groups, patients with AD or MCI had increased β-diversity compared with healthy controls.

  11. Rapid improvement in Alzheimer's disease symptoms following fecal microbiota transplantation: a case report

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of international medical research 2020-06-01 Disease mechanisms

    Alzheimer's disease (AD), the most common form of dementia, is a leading cause of death and a major cause of morbidity in older people.

  12. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature medicine 2019-01-07 Tau biomarkers

    Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure.

  13. Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in neurology 2018-08-15 Disease mechanisms

    Alzheimer's disease (AD) is associated with cognitive dysfunction.

  14. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature medicine 2018-06-11 Drug development

    Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases 1,2 .

  15. Glucagon-Like Peptide-1 Decreases Intracerebral Glucose Content by Activating Hexokinase and Changing Glucose Clearance during Hyperglycemia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Cerebral Blood Flow & Metabolism 2012-08-29 Drug development

    Type 2 diabetes and hyperglycemia with the resulting increase of glucose concentrations in the brain impair the outcome of ischemic stroke, and may increase the risk of developing Alzheimer's disease (AD).

  16. Parkinson's disease, insulin resistance and novel agents of neuroprotection

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2012-02-17 Drug development

    Multiple avenues of research including epidemiology, molecular genetics and cell biology have identified links between Parkinson's disease and type 2 diabetes mellitus.

  17. Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025-12 Disease mechanisms

    Among the natural extracts tested, PanQ emerged as the most effective for increasing the active CatB isoform in correspondence with enhanced levels of synaptic proteins and the autophagy marker LC3-II.

  18. Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia (New York, N. Y.) 2025-10-07 Biomarkers

    As expected, males had higher lean mass and VO2peak than females (p = 0.01), but groups did not differ in body mass index (p = 0.51).

  19. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Nature communications 2024-09-27 Disease mechanisms

    Despite recent advances, severe acute pancreatitis (SAP) remains a lethal inflammation with limited treatment options.

  20. APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Cellular & molecular biology letters 2024-06-12 Genetics

    The pathway analysis of six major cell types revealed a strong association between APOE2 and cellular stress and energy metabolism, particularly in excitatory and inhibitory neurons, which was found to be more pronounced in the presence of beta-amyloid (Aβ).

  21. Dietary Interventions to Prevent or Delay Alzheimer's Disease: What the Evidence Shows

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Current nutrition reports 2020-09 Prevention and risk

    A variety of potentially modifiable risk factors have been investigated in an attempt to delay/prevent Alzheimer's disease (AD).

  22. Nutrition and immunology in mental health: Precision medicine and integrative approaches to address unmet clinical needs in psychiatric treatments

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain, behavior, and immunity 2019-09-27 Prevention and risk

    The 'monoamine hypothesis' is insufficient in approaching the aetiology of psychiatric disorders or in developing novel therapies.

  23. Kynurenine pathway changes in late-life depression with memory deficit

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Psychiatry research 2018-08-13 Risk factors

    Kynurenine pathway (KP) activation is associated with many neuropsychiatric diseases, such as major depressive disorder (MDD) and Alzheimer's disease (AD).

  24. Resveratrol for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Annals of the New York Academy of Sciences 2017-08-16 Clinical trials

    The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's disease (AD).

  25. The metabolic-brain axis: GLP-1 signaling, insulin resistance, and obesity pharmacotherapy in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Metabolism: clinical and experimental 2026-10-30 Drug development

    The intersection of metabolic disease and neurodegeneration represents one of the most consequential frontiers in translational neuroscience.

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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