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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2020-08-17 Disease mechanisms

    The intestinal barrier is essential in human health and constitutes the interface between the outside and the internal milieu of the body.

  2. Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. BMC complementary medicine and therapies 2020-08-01 Drug development

    Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example.

  3. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2020-07-29 Disease mechanisms

    The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD).

  4. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Lancet. Neurology 2020-07-27 Disease mechanisms

    Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of glucose metabolism in peripheral tissues.

  5. Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biochimica et biophysica acta. Molecular basis of disease 2020-07-02 Drug development

    Following acute myocardial infarction, re-establishment of coronary perfusion aggravates further injuries in the heart and remote organs including the brain as a consequence of ischemia/reperfusion (I/R) injury.

  6. Clinical and public health implications of periodontal and systemic diseases: An overview

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Periodontology 2000 2020-06-01 Costs and economics

    Severe periodontitis is defined by extensive loss of the tooth attachment apparatus.

  7. The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular and infection microbiology 2020-05-28 Disease mechanisms

    Mucus is integral to gut health and its properties may be affected in neurological disease.

  8. Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. AMB Express 2020-04-24 Drug development

    Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases (NDD) characterized by progressive degeneration of the central nervous system, and few medications are available to halt the progression of AD and PD.

  9. Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrition & diabetes 2020-04-22 Disease mechanisms

    Akk effectively improved glucose tolerance, intestine barrier dysfunction and dyslipidemia in AD model mice.

  10. The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Foods (Basel, Switzerland) 2020-03-23 Brain scans and imaging

    Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea.

  11. The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular and infection microbiology 2020-03-18 Disease mechanisms

    Gut microbiome is a community of microorganisms in the gastrointestinal tract.

  12. Liraglutide Protects Against Brain Amyloid-β 1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2020-03-04 Drug development

    Alzheimer's disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (Aβ) peptide and hyperphosphorylated tau (p-tau), respectively) and memory loss.

  13. Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International Journal of Molecular Sciences 2020-03-03 Drug development

    Neuronal insulin resistance is a significant feature of Alzheimer's disease (AD).

  14. The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain and Behavior 2020-01-20 Drug development

    Our results demonstrate that DA5‐CH has neuroprotective effects in the STZ‐induced animal model and that DA5‐CH has potential to treat neurodegenerative disorders such as AD.

  15. The progress of gut microbiome research related to brain disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2020-01-17 Disease mechanisms

    There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior.

  16. The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. American journal of Alzheimer's disease and other dementias 2020-01-01 Drug development

    Alzheimer's disease (AD) is a neurodegenerative disorder for which there is no cure.

  17. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Oxidative medicine and cellular longevity 2019-11-11 Risk factors

    Reactive species produced in the cell during normal cellular metabolism can chemically react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing their oxidative modifications leading to alterations in their compositions and potential damage to their cellular activities.

  18. How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Diabetes, metabolic syndrome and obesity : targets and therapy 2019-10-24 Prevention trials

    Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as "civilization diseases", like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer's disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations.

  19. Time to test antibacterial therapy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain : a journal of neurology 2019-10-01 Treatments

    Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and hyperphosphorylated tau.

  20. Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2019-09-23 Disease mechanisms

    Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection.

  21. Physical Activity and Brain Health

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Genes 2019-09-17 Prevention trials

    Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution.

  22. The endotoxin hypothesis of neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2019-09-13 Disease mechanisms

    The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration.

  23. Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific Reports 2019-08-14 Disease mechanisms

    To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer’s disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB activation in lipopolysaccharide (LPS)-stimulated BV-2 cells, and examined whether NK46 could simultaneously alleviate gut dysbiosis and cognitive decline in male 5xFAD-transgenic (5XFAD-Tg, 6 months-old) and aged (18 months-old) mice.

  24. The use of zebrafish (Danio rerio) as biomedical models

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Animal Frontiers 2019-06-25 Disease mechanisms

    Animal models provide consistency and validity of research results from in vitro studies or studies with rodents.

  25. Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of tryptophan research : IJTR 2019-06-19 Disease mechanisms

    The kynurenine pathway is important in cellular energy generation and limiting cellular ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD + (nicotinamide adenine dinucleotide).

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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