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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 1999-03-01 Disease mechanisms

    The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important.

  2. Glutamate in CNS disorders as a target for drug development: an update

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Drug news & perspectives 1998-11-01 Risk factors

    The authors provide an extensive review of new data related to the role of glutamate in CNS disorders, describing new aspects in glutamate and glutamatergic receptors-NMDA receptors, NR2B-selective antagonists, non-NMDA ionotropic glutamate receptors, N-acetylaspartylglutamate, and glutamate and glycine transporters.

  3. The Impact of Gender and Estrogen on Striatal Dopaminergic Neurotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 1998-05-01 Biomarkers

    The reproductive properties of estrogen are well established, but it is now evident that this steroid hormone has substantial modulatory capabilities in nonreproductive systems.

  4. Cyclooxygenases 1 and 2

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of pharmacology and toxicology 1998-01-01 Inflammation and the immune system

    Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid.

  5. Human neuronal nicotinic receptors

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 1997-10-01 Clinical safety

    Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative, behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptors (NAChRs).

  6. Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Neuroscience Research 1997-09-15 Disease mechanisms

    The transcription factor NF-kappaB is expressed in neurons wherein it is activated in response to a variety of stress- and injury-related stimuli including exposure to cytokines such as tumor necrosis factor-alpha (TNFalpha), and excitotoxic and oxidative insults.

  7. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1997-07-01 Disease mechanisms

    Oxidative stress is believed to play important roles in neuronal cell death associated with many different neurodegenerative conditions (e.g., Alzheimer's disease, Parkinson's disease, and cerebral ischemia), and it is believed also that apoptosis is an important mode of cell death in these disorders.

  8. Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Neurochemistry 1997-07-01 Disease mechanisms

    Deposits of amyloid beta-peptide (A beta), reduced glucose uptake into brain cells, oxidative damage to cellular proteins and lipids, and excitotoxic mechanisms have all been suggested to play roles in the neurodegenerative process in Alzheimer's disease.

  9. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 1997-05-01 Disease mechanisms

    Recent studies have demonstrated oxidative damage is one of the salient features of Alzheimer's disease (AD).

  10. Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1997-02-01 Biomarkers

    Metallothionein-III (MT-III), a brain-specific member of the metallothionein family of metal-binding proteins, is abundant in glutamatergic neurons that release zinc from their synaptic terminals, such as hippocampal pyramidal neurons and dentate granule cells.

  11. Adenosine A2 receptor-mediated excitatory actions on the nervous system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 1996-02-01 Brain scans and imaging

    The distribution, molecular structure and role of adenosine A2 receptors in the nervous system, is reviewed.

  12. Pharmacology of nicotine: addiction and therapeutics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of pharmacology and toxicology 1996-01-01 Risk factors

    Nicotine maintains tobacco addiction and has therapeutic utility to aid smoking cessation and possibly to treat other medical diseases.

  13. Oxidative stress in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of pharmacology and toxicology 1996-01-01 Disease mechanisms

    Oxidative stress refers to the cytopathologic consequences of a mismatch between the production of free radicals and the ability of the cell to defend against them.

  14. Vitamin E in Humans: Demand and Delivery

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual Review of Nutrition 1996-01-01 Prevention and risk

    How much vitamin E is enough? An established use of supplemental vitamin E in humans is in the prevention and therapy of deficiency symptoms.

  15. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 1995-11-01 Disease mechanisms

    Four biomarkers of neuronal protein oxidation [W/S ratio of MAL-6 spin-labeled synaptosomes, phenylhydrazine-reactive protein carbonyl content, glutamine synthetase (GS) activity, creatine kinase (CK) activity] in three brain regions [cerebellum, inferior parietal lobule (IPL), and hippocampus (HIP)] of Alzheimer's disease (AD)-demented and age-matched control subjects were assessed.

  16. Role of glucose in regulating the brain and cognition

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of clinical nutrition 1995-04-01 Down syndrome and Alzheimer's

    Extensive evidence indicates that relatively modest increases in circulating glucose concentrations enhance learning and memory processes in rodents and humans.

  17. Oxidative stress: the paradox of aerobic life

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical Society symposium 1995-01-01 Brain scans and imaging

    Alternatively, compounds found in certain foods may be able to significantly bolster biological resistance against oxidants.

  18. Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Psychoneuroendocrinology 1995-01-01 Disease mechanisms

    In addition to a physiological role for CRF in integrating the responses of the brain, endocrine and immune systems to physiological, psychological and immunological stimuli, recent clinical data implicate CRF in the etiology and pathophysiology of various endocrine, psychiatric, neurologic and inflammatory illnesses.

  19. Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Neurochemistry 1994-08-01 Disease mechanisms

    The evidence is compelling that free radicals, plus increases in free cytosolic Ca2+ and Na+, figure prominently in neuronal death after exposure to glutamate and dicarboxylic excitotoxins such as NMDA and kainate.

  20. GFAP mRNA increases with age in rat and human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 1993-09-01 Biomarkers

    Glial fibrillary acidic protein (GFAP) mRNA was examined by RNA blot hybridization in three age groups of two cohorts of male F-344 rats and in 47 human postmortem brain samples.

  21. Free radicals in brain metabolism and pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. British medical bulletin 1993-07-01 Prevention and risk

    Reactive oxygen metabolites (ROM), namely superoxide and hydroxyl free radicals and hydrogen peroxide, are produced as a consequence of the physiological metabolic reactions and functioning of the central nervous system.

  22. NON-CHOLINERGIC NEUROTRANSMITTER ABNORMALITIES IN ALZHEIMER'S DISEASE

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. British Medical Bulletin 1986-01-01 Disease mechanisms

    Apart from the damago to ascending cholinergic projections in Alzheimer's disease, biochemical studies on human brain post mortem have revealed a number of other neurochemical abnormalities.

  23. Neuropeptides in Alzheimer type dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the neurological sciences 1983-12-01 Disease mechanisms

    Five neuropeptides (cholecystokinin (CCK), vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), neurotensin (NT) and substance P (SP)) were measured in 14 brain areas (4 cortical areas, hippocampus, amygdala, 3 striatal areas, 2 thalamic areas and 3 subcortical areas-- septum, substantia innominata and hypothalamus) in 12 brains with neuropathologically confirmed Alzheimer type change and in 13 control brains.

  24. n‐3 Omega fatty acids: a review of current knowledge

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. International Journal of Food Science & Technology 2010-02-10 Prevention and risk

    The very long chain polyunsaturated fatty acids (PUFAs) (C18–C22) and n‐3 Omega PUFAs are apparently widely accepted as a part of modern nutrition because of their beneficial effects on metabolism.

  25. Endocannabinnoids innervate Circadian mechinary mitigating neuroinflammation, amyloidogenesis and cognition phenotypic to AD

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Authorea Preprints 2026-10-29 Brain scans and imaging

    Constant LL exposure induced complete arrhythmicity and impaired recognition, working, and spatial reference memory.

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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