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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurobiology of aging 2012-04-13 Risk genes beyond APOE

    In order to assess the frequency of mutations in the known Alzheimer's disease causative genes in Turkish dementia patients we screened amyloid precursor protein (APP), PSEN1 and PSEN2 for mutations in a cohort of 98 Turkish dementia families.

  2. Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Journal of Alzheimer's disease : JAD 2020 Genetics

    We identified rs13374761-A in SLAMF1 gene associated with less memory decline (MAF = 0.071, β= 0.0103, p = 4.14×10-8).

  3. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Lancet. Neurology 2010-10-01 Genetics

    In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).

  4. Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2025-01-16 Genetics

    Among all participants (mean age 66.7 ± 6.5 years, 100% non-Hispanic White), 451 (6.6%) were using statins at baseline.

  5. APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024-10-11 Genetics

    Significant interactions were found between APOE ε4 status and mindfulness and social engagement on cognitive reserve, indicating stronger associations for APOE ε4 carriers.

  6. Improving genetic risk modeling of dementia from real-world data in underrepresented populations

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Communications biology 2024-08-25 Disparities

    Genetic risk modeling for dementia offers significant benefits, but studies based on real-world data, particularly for underrepresented populations, are limited.

  7. Polygenic effects on the risk of Alzheimer's disease in the Japanese population

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2024-02-27 Genetics

    The PRS using 131 SNPs had an effect independent of APOE.

  8. Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Cell reports 2022-11-29 Genetics

    Translating human genetic findings (genome-wide association studies [GWAS]) to pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease (AD).

  9. Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. BMC medical genomics 2022-08-01 Genetics

    We propose a novel method to identify disease-related genetic variants enriched by imaging endophenotypes, which are the imaging traits associated with both genetic factors and disease status.

  10. Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Frontiers in molecular neuroscience 2022-06-10 Genetics

    Cortical neuron loss is a pathological hallmark of late-onset Alzheimer's disease (AD).

  11. Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer’s Disease and Longitudinal Change in Hippocampus Function

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of Alzheimer's Disease 2022-02-01 Biomarkers

    Increased p-tau181 was observed for both ɛ4 carriers and non-carriers close to AD onset, but exclusively for ɛ4 carriers in the early preclinical groups (7- and 13-years pre-AD).

  12. Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2021-02-13 Risk genes beyond APOE

    Recent genetic progress allows the molecular diagnosis of young-onset dementia, including Alzheimer's disease (AD) and frontotemporal dementia (FTD).

  13. Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurobiology of aging 2020-09-12 Risk genes beyond APOE

    Alzheimer's disease is the most frequent diagnosis of neurodegenerative dementia with early (≤65 years) and late (>65 years) onset ages in familial and sporadic patients.

  14. MAPT haplotype-stratified GWAS reveals differential association for AD risk variants

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-05-13 Genetics

    We identified 11 loci-5 in H2-non-carriers and 6 in H2-carriers-although none of the MAPT haplotype-specific associations achieved genome-wide significance.

  15. High-throughput and efficient multilocus genome-wide association study on longitudinal outcomes

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Bioinformatics (Oxford, England) 2020-05-01 Genetics

    Extensive simulations demonstrated that the proposed approach not only provided accurate selection of single nucleotide polymorphisms (SNPs) with comparable or higher power but also robust control of false positives.

  16. Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Scientific reports 2020-01-29 Genetics

    Variations in the human genome have been found to be an essential factor that affects susceptibility to Alzheimer's disease.

  17. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. An international journal on information fusion 2020-01-07 Risk genes beyond APOE

    Despite subjects with Dominantly-Inherited Alzheimer's Disease (DIAD) represent less than 1% of all Alzheimer's Disease (AD) cases, the Dominantly Inherited Alzheimer Network (DIAN) initiative constitutes a strong impact in the understanding of AD disease course with special emphasis on the presyptomatic disease phase.

  18. Genome-wide association study of hippocampal atrophy rate in non-demented elders

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Aging 2019-11-23 Genetics

    Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear.

  19. Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Annals of translational medicine 2019-11 Genetics

    Two novel SNPs (rs465401 and rs460420), both near the ADAMTS1 gene on chromosome 21, showed genome-wide significant associations with CSF NFL.

  20. Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Translational psychiatry 2019-05-24 Genetics

    Mild-cognitive impairment (MCI) occurs in up to one-fifth of individuals over the age of 65, with approximately a third of MCI individuals converting to dementia in later life.

  21. Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2015-07-01 Genetics

    Numerous genetic susceptibility and protective markers for AD and disease biomarkers have been identified and replicated using ADNI data and have heavily implicated immune, mitochondrial, cell cycle/fate, and other biological processes.

  22. Apolipoprotein E Allele and Hearing Thresholds in Older Adults

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. American journal of Alzheimer's disease and other dementias 2014-06-06 Risk factors

    Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021).

  23. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature 2013-12-11 Genetics

    Genome-wide association studies (GWAS) have identified several risk variants for late-onset Alzheimer's disease (LOAD).

  24. Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2013-10-17 Treatments

    The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer's disease (AD).

  25. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2013-03-25 Genetics

    SPON1 has not been previously associated with AD risk, but is plausibly related because the gene product binds to the amyloid precursor protein and inhibits its cleavage by β-secretase.

From across this topic

9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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