Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 933 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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DNA methylation is a major control program that modulates gene expression in a plethora of organisms.
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Psychiatric disorders are among the most intractable enigmas in medicine.
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Neurodegeneration in the brains of Huntington's disease patients is accompanied by widespread changes in gene regulatory networks.
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36/100
Ts65Dn is a mouse model of Down syndrome: a syndrome that results from chromosome (Chr) 21 trisomy and is associated with congenital defects, cognitive impairment, and ultimately Alzheimer's disease.
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Alzheimer disease is the most common cause of dementia.
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Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and inflammation.
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The interaction between gene and environment is known to play a major role in the etiology of several neuropsychiatric disorders, including Alzheimer's disease (AD).
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Alzheimer's disease (AD) is a complex disorder with a clear genetic component.
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The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown.
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Increasing evidence is implicating mitochondrial dysfunction as a central factor in the etiology of Alzheimer's disease (AD).
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Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting millions of people worldwide.
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Genome-wide association studies (GWAS) have gained considerable momentum over the last couple of years for the identification of novel complex disease genes.
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Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability.
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36/100
Apolipoprotein (apo) E has roles beyond lipoprotein metabolism.
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MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown.
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Alzheimer's disease (AD) is associated with regional reductions in fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the cerebral metabolic rate for glucose, which may begin long before the onset of histopathological or clinical features, especially in carriers of a common AD susceptibility gene.
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In both trisomy 21 and rare cases of triplication of amyloid precursor protein (APP) Alzheimer's disease (AD) pathological changes are believed to be secondary to increased expression of APP.
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We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human disease to create a phenome-interactome network.
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In this paper, we develop a method based on support vector machines (SVMs) that starting from the protein sequence information can predict whether a new phenotype derived from a nsSNP can be related to a genetic disease in humans.
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Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins.
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Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the Western world.
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The need for methods to identify disease biomarkers is underscored by the survival-rate of patients diagnosed at early stages of cancer progression.
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This review examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease.
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Eugenic selection of embryos is now possible by employing in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD).
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Apolipoprotein E protein is strategically located at the same anatomic locus where drusen are situated, and the retinal pigmented epithelium is the most likely local biosynthetic source of apolipoprotein E at that location.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Predicting Rates of Cognitive Decline in Older Adults with Brain- and Cardiac-Imputed Transcripts
- Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients
- Alzheimer's Disease: An Updated Overview of Its Genetics
- Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer's disease at 12p12.1
- Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease
- A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
- A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease
- ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
- Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction
- GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease