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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. GenoRisk: A polygenic risk score for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & dementia (New York, N. Y.) 2021-09-30 Genetics

    The elastic net model that included age, age x sex interaction, allelic APOE terms, and 29 additional SNPs performed the best.

  2. Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2021-08-05 Genetics

    The PRS for AD was significantly higher in APOE ε4 homozygote AD cases compared to older cognitively healthy APOE ε4/ε4 controls (odds ratio [OR] 8.39; confidence interval [CI] 2.0-35.2; P = .003).

  3. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Cell stem cell 2021-04-27 Genetics

    Sporadic Alzheimer's disease (AD) exclusively affects elderly people.

  4. Interaction Between APOE Genotype and Diabetes in Longevity

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of Alzheimer's disease : JAD 2021 Genetics

    Diabetes was associated with shorter lifespan in APOE3 carriers (n = 12,415, HR = 1.29, 95%CI = 1.17-1.42, p < 0.001) and APOE2 carriers (n = 2,390, HR = 1.37, 95%CI = 1.10-1.69, p = 0.016), while such associations were weaker and not significant in APOE4 carriers (n = 9,490, HR = 1.11, 95%CI = 0.99-1.24, p = 0.162).

  5. APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The Journals of Gerontology Series A 2020-05-25 Clinical safety

    The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common.

  6. Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2019-05-18 Brain scans and imaging

    Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus.

  7. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature medicine 2018-10-29 Brain scans and imaging

    Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer's disease.

  8. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Annals of clinical and translational neurology 2018-03-13 Genetics

    A variant in AKAP9, p.R434W, segregated significantly with LOAD in two large families (OR = 5.77, 95% CI: 1.07-30.9, P = 0.041).

  9. The Association Between Serum ApoE Genetic Polymorphism and Serum Lipid Level in Hemodialysis Patients

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Genetic Testing and Molecular Biomarkers 2015-01-07 Genetics

    Growing evidence indicates that apolipoprotein E (ApoE) is one of the most important candidate genes for influencing the development of hemodialysis (HD).

  10. Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Molecular carcinogenesis 2000-01 Genetics

    Apolipoprotein E (apoE) is a polymorphic gene involved in lipid metabolism with three common variant alleles (epsilon2, epsilon3, and epsilon4).

  11. Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Genomics, proteomics & bioinformatics 2025-10-28 Genetics

    Subjective cognitive decline (SCD) is widely regarded as a potential preclinical stage of Alzheimer's disease (AD), yet its genetic basis remains poorly understood.

  12. A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's research & therapy 2025-07-15 Treatments

    ApoE4 levels ascertained by the e4Quant test exhibited clear genotype-dependent stratification.

  13. GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature genetics 2024-10-08 Genetics

    Genome-wide association studies (GWAS) have identified >80 Alzheimer's disease and related dementias (ADRD)-associated genetic loci.

  14. Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Frontiers in aging neuroscience 2022-03-15 Genetics

    Alzheimer's disease (AD) is the most common form of dementia and a growing public health burden in the United States.

  15. Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. The Lancet. Neurology 2022-03-01 Genetics

    We retrospectively assessed the diagnostic accuracy of whole genome sequencing to detect the most common repeat expansion loci associated with neurological outcomes (AR, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, C9orf72, CACNA1A, DMPK, FMR1, FXN, HTT, and TBP) using samples obtained within the National Health Service in England from patients who were suspected of having neurological disorders; previous PCR test results were used as the reference standard.

  16. An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature neuroscience 2021-04-19 Genetics

    UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes.

  17. Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Acta neuropathologica communications 2021-03-23 Genetics

    Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer's disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to progression to dementia.

  18. Deep representation learning of electronic health records to unlock patient stratification at scale

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. NPJ digital medicine 2020-07-17 Digital health tools

    Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine.

  19. Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of Alzheimer's disease : JAD 2020 Risk factors

    Methylation across all the CpGs strongly correlated with each other.

  20. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2019-01-03 Genetics

    We identified associations in EAs with variants in 12 novel loci.

  21. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Scientific data 2018-09-11 Genetics

    Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability.

  22. Human brain arousal in the resting state: a genome-wide association study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Molecular psychiatry 2018-04-27 Genetics

    Arousal affects cognition, emotion, and behavior and has been implicated in the etiology of psychiatric disorders.

  23. Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2017-08-14 Genetics

    Higher GRS predicted mortality (hazard ratio = 1.05; 95% confidence interval: 1.00-1.10, P = .04).

  24. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Molecular psychiatry 2016-04-05 Genetics

    People's differences in cognitive functions are partly heritable and are associated with important life outcomes.

  25. Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. PLoS medicine 2015-06-16 Drug development

    Inherited lifetime exposure to higher SBP is associated with lower AD risk.

From across this topic

9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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