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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Spatial Transcriptomic Analysis Identifies a SERPINA3-Expressing Astrocytic State Associated with the Human Neuritic Plaque Microenvironment

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2024-11-14 Genetics

    Single-nucleus transcriptomic studies have revealed glial cell states associated with Alzheimer's disease; however, these nuclei are dissociated from the complex architecture of the human neocortex.

  2. Phenotype Scoring of Population Scale Single-Cell Data Dissects Alzheimer's Disease Complexity

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv : the preprint server for health sciences 2024-11-02 Genetics

    The complexity of Alzheimer's disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms (NPSs).

  3. Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research square 2024-08-16 Genetics

    Although human cerebellum is known to be neuropathologically impaired in Alzheimer's disease (AD) and AD-related dementias (ADRD), the cell type-specific transcriptional and epigenomic changes that contribute to this pathology are not well understood.

  4. The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2024-06-28 Biomarkers

    Aβ42/40 and Aβ37/42 ratios were associated with AAO across PSEN2 variants, strongly driven by PSEN2 variants with PSEN1 homologs.

  5. Pervasive biases in proxy GWAS based on parental history of Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2023-10-17 Genetics

    Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history.

  6. A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv : the preprint server for health sciences 2023-09-08 Biomarkers

    Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases.

  7. Human brain single nucleus cell type enrichments in neurodegenerative diseases

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv : the preprint server for health sciences 2023-07-01 Genetics

    Single cell RNA sequencing has opened a window into clarifying the complex underpinnings of disease, particularly in quantifying the relevance of tissue- and cell-type-specific gene expression.

  8. Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease

    ⚠ Retracted — do not rely on it alzhub usefulness score 10 out of 100. Nature 2013-07-24 Genetics

    Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E ε4 allele (referred to here as APOE4), as well as non-genetic determinants including ageing.

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