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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Molecular psychiatry 2013-02-19 Genetics

    Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in Alzheimer's disease (AD) pathogenesis with a significant genetic contribution.

  2. Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2010-05-01 Genetics

    The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status.

  3. Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. BMJ 1997-10-25 Risk factors

    46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease.

  4. Explainable variational autoencoder (E-VAE) model using genome-wide SNPs to predict dementia

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of biomedical informatics 2023-11-04 Genetics

    We obtained a predictive accuracy of 0.71 (95 % CI [0.59, 0.84]) with an AUC of 0.69 in the HRS test dataset and got an accuracy of 0.62 (95 % CI [0.56, 0.68]) with an AUC of 0.63 in the ROSMAP dataset.

  5. Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature neuroscience 2023-06-01 Genetics

    Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes that occur in specific cell types have not been fully characterized.

  6. Multi-omic integration via similarity network fusion to detect molecular subtypes of ageing

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain communications 2023-04-04 Genetics

    Fusion of all five data modalities (n = 111) yielded two subtypes (n S1 = 53, n S2 = 58), which were nominally associated with diffuse amyloid plaques; however, this effect was not significant after correction for multiple testing.

  7. Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-12-04 Genetics

    Mutation screening revealed a novel probably pathogenic mutation (PSEN1 p.Leu232Phe).

  8. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-10-17 Risk genes beyond APOE

    We identified 133 unique and shared metabolites associated with ADAD, TREM2, and sAD.

  9. Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurobiology of aging 2022-03-07 Genetics

    We investigated which factors might explain the differences between the frequencies of brain β-amyloid (Aβ) deposition in Korean and European cognitively normal individuals (CNs).

  10. Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2022 Genetics

    Disrupted iron homeostasis is associated with several neurodegenerative diseases, including Alzheimer's disease (AD), and may be partially modulated by genetic risk factors.

  11. The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-12-08 Risk factors

    Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience.

  12. Genetic underpinnings of sociability in the general population

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021-05-30 Genetics

    Levels of sociability are continuously distributed in the general population, and decreased sociability represents an early manifestation of several brain disorders.

  13. Why Inclusion Matters for Alzheimer's Disease Biomarker Discovery in Plasma

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of Alzheimer's disease : JAD 2021 Disparities

    In total, 740 proteins were identified of which, 25 differentially-expressed proteins in AD came from comparisons within a single racial and ethnic background group.

  14. APOEε4 potentiates the relationship between amyloid-β and tau pathologies

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Molecular psychiatry 2020-03-11 Brain scans and imaging

    APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and is associated with cerebral amyloid-β.

  15. Genome-wide association analysis of secondary imaging phenotypes from the Alzheimer's disease neuroimaging initiative study

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. NeuroImage 2016-10-04 Genetics

    The aim of this paper is to systematically evaluate a biased sampling issue associated with genome-wide association analysis (GWAS) of imaging phenotypes for most imaging genetic studies, including the Alzheimer's Disease Neuroimaging Initiative (ADNI).

  16. Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurobiology of aging 2014-02-05 TREM2 and immune genetics

    Recent studies have reported that a rare nonsynonymous variant rs75932628-T in the TREM2 gene is associated with increased risk of Alzheimer's disease and Parkinson's disease (PD) in European-descended populations.

  17. Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. American journal of medical genetics. Part A 2012-09-28 Genetics

    Niemann-Pick disease, type C1 (NPC1) is a lipid storage disorder that results in progressive neurological impairment.

  18. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature genetics 2024-03-21 Genetics

    The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied.

  19. A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature neuroscience 2019-12-01 Genetics

    There is currently little information available about how individual cell types contribute to Alzheimer's disease.

  20. Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature Communications 2019-05-21 Genetics

    Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer's disease (AD).

  21. Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Scientific data 2016-10-11 Genetics

    Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD).

  22. Phenome-wide analysis of genome-wide polygenic scores

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Molecular Psychiatry 2015-08-25 Genetics

    Genome-wide polygenic scores (GPS), which aggregate the effects of thousands of DNA variants from genome-wide association studies (GWAS), have the potential to make genetic predictions for individuals.

  23. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature genetics 2011-06-19 Genetics

    Progressive supranuclear palsy (PSP) is a movement disorder with prominent tau neuropathology.

  24. Clinical Phenotype of Apoe Ɛ4 Carriers In Patients With Vascular Dementia: A Cross-Sectional Study From Indonesia

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. F1000Res 2026-09-02 Lewy body dementia

    This study demonstrated that APOE4 carrier status was associated with lower MoCA-INA scores in this small VaD cohort.

  25. Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular neurodegeneration 2025-10-01 Genetics

    Transcriptomics and polygenic risk analysis position resilience as an intermediate AD state.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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