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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Pharmacogenetic studies in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurologia 2018-06-10 Treatments

    Potential pharmacogenetic biomarkers for AD have been identified; however, it is still necessary to conduct further research into other populations and to identify new biomarkers.

  2. Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Scientific data 2018-03-13 Genetics

    Patients with Alzheimer's disease (AD) and Parkinson's disease (PD) often have overlap in clinical presentation and brain neuropathology suggesting that these two diseases share common underlying mechanisms.

  3. FGWAS: Functional genome wide association analysis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. NeuroImage 2017-07-20 Genetics

    Functional phenotypes (e.g., subcortical surface representation), which commonly arise in imaging genetic studies, have been used to detect putative genes for complexly inherited neuropsychiatric and neurodegenerative disorders.

  4. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Genome medicine 2016-11-01 Genetics

    This transcriptomic network analysis of 19 brain regions provides a comprehensive assessment of the critical molecular pathways associated with AD pathology and offers new insights into molecular mechanisms underlying selective regional vulnerability to AD at different stages of the progression of cognitive compromise and development of the canonical neuropathological lesions of AD.

  5. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Aging 2015-12-01 Genetics

    There is an urgent need to develop molecular biomarkers of brain age in order to advance our understanding of age related neurodegeneration.

  6. The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Respiration 2015 Genetics

    The mean age was 51 ± 12 years. Forty-two of the patients had OSAS.

  7. Screening of CHCHD10 in a French cohort confirms the involvement of this gene in frontotemporal dementia with amyotrophic lateral sclerosis patients

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurobiology of aging 2014-07-24 Risk factors

    Mutations in the CHCHD10 gene have been recently identified in a large family with a complex phenotype variably associating frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS), cerebellar ataxia, myopathy, and hearing impairment.

  8. Mutational analysis in early-onset familial Alzheimer's disease in Mainland China

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurobiology of aging 2014-02-20 Risk genes beyond APOE

    Mutations of 3 causative genes, namely presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP), have been identified as the major causes of early-onset familial Alzheimer's disease (EOFAD).

  9. A genome-wide scan for common variants affecting the rate of age-related cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurobiology of aging 2011-11-04 Genetics

    Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic conditions of aging, including neurodegenerative and vascular disease.

  10. ApoE-4 and Age at Onset of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 1997-01-01 Genetics

    ApoE-4 was strongly associated with AD in this sample (allele frequency = 0.46 vs. 0.14 in controls, p < 0.000001).

  11. Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Human Molecular Genetics 1994-01-01 Genetics

    An association between the 19q13.2 chromosomal region and Alzheimer's disease (AD) has been reported in AD families and for sporadic AD.

  12. Apolipoprotein E polymorphism and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Lancet (London, England) 1993-09-01 Genetics

    Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques.

  13. Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer’s disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Acta neuropathologica 2025-02-25 Down syndrome and Alzheimer's

    Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer’s disease (AD).

  14. Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Cell 2023-09-01 Genetics

    Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are poorly understood.

  15. Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature neuroscience 2022-02-03 Genetics

    The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain incompletely understood.

  16. Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2021-07-23 Genetics

    Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD.

  17. scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2021-03-25 Genetics

    Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from multiple grand challenges, including the sequencing sparsity and complex differential patterns in gene expression.

  18. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2021-03-12 Genetics

    Genome-wide association studies (GWAS) have identified more than 40 loci associated with Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown, impeding a mechanistic understanding of AD pathogenesis.

  19. Machine learning identifies candidates for drug repurposing in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature communications 2021-02-15 Drug development

    Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results.

  20. Genetic predictors of participation in optional components of UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature Communications 2021-02-09 Genetics

    Large studies (e.g. UK Biobank) are increasingly used for GWAS and Mendelian randomization (MR) studies.

  21. Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature genetics 2021-01-28 Genetics

    Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's disease (AD) 1,2 , but how these loci confer AD risk is unclear.

  22. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature 2020-04-29 Tau biomarkers

    Vascular contributions to dementia and Alzheimer's disease are increasingly recognized 1-6 .

  23. Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer s Disease 2016-04-12 Biomarkers

    Higher HOMA-IR was associated with higher sAβPPβ and Aβ42 .

  24. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-03-15 Genetics

    We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007).

  25. Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2014-10-28 Getting a diagnosis

    There is no consensus for a blood-based test for the early diagnosis of Alzheimer's disease (AD).

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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