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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Structured Genome-Wide Association Studies with Bayesian Hierarchical Variable Selection

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Genetics 2019-04-22 Genetics

    It becomes increasingly important in using genome-wide association studies (GWAS) to select important genetic information associated with qualitative or quantitative traits.

  2. The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Genes 2019-03-15 Genetics

    Human longevity is a complex phenotype resulting from the combinations of context-dependent gene-environment interactions that require analysis as a dynamic process in a cohesive ecological and evolutionary framework.

  3. Dynamic DNA Methylation During Aging: A "Prophet" of Age-Related Outcomes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in genetics 2019-02-18 Genetics

    The biological markers of aging used to predict physical health status in older people are of great interest.

  4. GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current genetic medicine reports 2019-02-14 Genetics

    Neurodegenerative diseases, neuropsychiatric disorders, and related traits have highly complex etiologies but are also highly heritable and identifying the causal genes and biological pathways underlying these traits may advance the development of treatments and preventive strategies.

  5. Benefits and Challenges of Rare Genetic Variation in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current genetic medicine reports 2019-02-01 Genetics

    It is well established that sporadic Alzheimer's disease (AD) is polygenic with common and rare genetic variation alongside environmental factors contributing to disease.

  6. A Biophysical Approach to the Identification of Novel ApoE Chemical Probes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biomolecules 2019-01-29 Genetics

    Alzheimer's disease (AD) is the most common type of dementia and, after age, the greatest risk factor for developing AD is the allelic variation of apolipoprotein E (ApoE), with homozygote carriers of the ApoE4 allele having an up to 12-fold greater risk of developing AD than noncarriers.

  7. Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in genetics 2019-01-25 Genetics

    Alzheimer disease (AD) is the fourth major cause of death in the elderly following cancer, heart disease and cerebrovascular disease.

  8. Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Dialogues in clinical neuroscience 2019 Biomarkers

    Alzheimer's disease (AD)-a complex disease showing multiple pathomechanistic alterations-is triggered by nonlinear dynamic interactions of genetic/epigenetic and environmental risk factors, which, ultimately, converge into a biologically heterogeneous disease.

  9. Understanding the Role of ApoE Fragments in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurochemical research 2018-09-17 Genetics

    Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases.

  10. Discovery and validation of autosomal dominant Alzheimer's disease mutations

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Alzheimer's research & therapy 2018-07-18 Risk genes beyond APOE

    We propose that PSEN1 M84V, PSEN1 A396T, PSEN2 R284G, and APP T719N are likely pathogenic mutations, whereas PSEN1 c.379_382delXXXXinsG and PSEN2 L238F have uncertain pathogenicity.

  11. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current genetic medicine reports 2018-05-29 Genetics

    The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases.

  12. Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience 2018-04-18 Genetics

    Apolipoprotein E (ApoE) is an important lipid carrier in both the periphery and the brain.

  13. AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Human gene therapy. Clinical development 2018-03-13 Genetics

    Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly one in nine elderly people in the United States.

  14. Reprogramming neurodegeneration in the big data era

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current opinion in neurobiology 2018-01-10 Genetics

    Recent genome-wide association studies (GWAS) have identified numerous genetic risk variants for late-onset Alzheimer's disease (AD) and Parkinson's disease (PD).

  15. ApoE and Neurodegenerative Diseases in Aging

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Advances in experimental medicine and biology 2018 Genetics

    Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear.

  16. Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The journal of prevention of Alzheimer's disease 2018 Genetics

    Population-attributable risk models estimate that up to one-third of Alzheimer's disease (AD) cases may be preventable through risk factor modification.

  17. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurobiology of aging 2017-12-30 Genetics

    Alzheimer's disease (AD) is heritable with complex genetic underpinnings.

  18. ApoE4 Accelerates Early Seeding of Amyloid Pathology

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuron 2017-12-06 Genetics

    Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the pathogenesis of Alzheimer's disease (AD).

  19. MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular neurobiology 2017-09-06 Risk genes beyond APOE

    MicroRNAs are small non-coding RNAs that function as regulators of gene expression.

  20. Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current neurology and neuroscience reports 2017-08-21 Genetics

    We aimed to summarize the recent advances in genetic findings of Alzheimer's disease (AD), focusing on traditional single-marker and gene approaches and non-traditional ones, i.e., polygenic and epistatic components.

  21. [DIAN/DIAN-J/DIAN-TU]

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain and nerve = Shinkei kenkyu no shinpo 2017-07 Risk genes beyond APOE

    The Dominantly Inherited Alzheimer's Network (DIAN) observational study compared pathophysiological markers between mutation carriers and non-carriers in autosomal dominant Alzheimer's disease.

  22. Rare causes of early-onset dystonia-parkinsonism with cognitive impairment: a de novo PSEN-1 mutation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurogenetics 2017-06-29 Risk genes beyond APOE

    Mutations in PSEN1 are responsible for familial Alzheimer's disease (FAD) inherited as autosomal dominant trait, but also de novo mutations have been rarely reported in sporadic early-onset dementia cases.

  23. Dementia and osteoporosis in a geriatric population: Is there a common link?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. World journal of orthopedics 2017-05-18 Prevention and risk

    Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations.

  24. Apolipoprotein E: the resilience gene

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Experimental brain research 2017-03-15 Genetics

    The apolipoprotein E (apoE) gene has been implicated in various conditions, most notably Alzheimer's disease and coronary artery disease.

  25. ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Trends in endocrinology and metabolism: TEM 2017-01-02 Disease mechanisms

    As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are becoming a significant burden on patients, their families, and health-care systems.

From across this topic

8 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

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