Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations
Jin Li, Xiaolong Zhang, Ang Li, Shu Liu, Wen Qin, Chunshui Yu, Yong Liu, Bing Liu et al.. Neurobiology of aging, 2017-12-30
Topic: Genetics and APOE
Alzheimer's disease (AD) is heritable with complex genetic underpinnings. Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated. In the present study, we examined the voxel-wise effect of AD PGRS on the entire brain and the influence of AD PGRS on cognitive function in 2 independent healthy young cohorts. In both cohorts, an elevated AD PGRS was associated with a smaller precuneal volume, and the effect remained after excluding the APOE genotype. No correlation was found between AD PGRS and any cognitive measure in either sample. Finding a negative correlation between the AD PGRS and the precuneal volume could help to elucidate the mechanism of the genetic risk for AD and could provide a potential biomarker for early detection and possible interventions in AD.
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APA 7th
Li, J., Zhang, X., Li, A., Liu, S., Qin, W., Yu, C., et al. (2018). Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2017.12.022
Vancouver
Li J, Zhang X, Li A, Liu S, Qin W, Yu C, et al. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations. Neurobiology of aging. 2018. doi:10.1016/j.neurobiolaging.2017.12.022. PMID: 29358118.
BibTeX
@article{li2018-29358118,
author = {Li, Jin and Zhang, Xiaolong and Li, Ang and Liu, Shu and Qin, Wen and Yu, Chunshui and Liu, Yong and Liu, Bing and others},
title = {{Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations}},
journal = {Neurobiology of aging},
year = {2018},
doi = {10.1016/j.neurobiolaging.2017.12.022},
pmid = {29358118},
url = {https://doi.org/10.1016/j.neurobiolaging.2017.12.022}
}
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Key findings
- Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated.
- In both cohorts, an elevated AD PGRS was associated with a smaller precuneal volume, and the effect remained after excluding the APOE genotype.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29358118) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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