Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Human apolipoprotein E (ApoE) was first identified as a polymorphic gene in the 1970s; however, the genetic association of ApoE genotypes with late-onset sporadic Alzheimer's disease (sAD) was only discovered 20 years later.
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For decades, the study of genetically isolated populations has improved our understanding and management of genetic diseases that affect all populations.
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43/100
Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data.
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The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for Alzheimer's disease (AD).
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Apolipoprotein E (APOE) is a major cholesterol carrier responsible for lipid transport and injury repair in the brain.
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The glucagon-like peptide-1 receptor (GLP-1R) agonists reduce glycated hemoglobin in patients with type 2 diabetes.
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The MR analysis conducted in this study found no statistically significant causal association between 20 dietary habits and the risk of AD (All p > 0.05).
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Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common form of dementia.
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Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity.
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Highly penetrant autosomal dominant Alzheimer's disease (ADAD) comprises a distinct disease entity as compared to the far more prevalent form of AD in which common variants collectively contribute to risk.
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GWAS focuses on significance loosing false positives; machine learning probes sub-significant features relying on predictivity.
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In this narrative review, we delved into the intricate interplay between Apolipoprotein E (APOE) alleles (typically associated with Alzheimer's disease-AD) and alpha-synucleinopathies (aS-pathies), involving Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), and multiple-system atrophy (MSA).
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Late-onset Alzheimer's disease is the leading cause of dementia worldwide, accounting for a growing burden of morbidity and mortality.
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Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race.
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Among CN, APOE4 carriers showed lower entorhinal cortex neurite density than non-carriers, whereas APOE2 carriers showed lower cingulum neurite density than non-carriers.
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Dementia is a syndrome that can cause a number of progressive illnesses that affect memory, thinking, and ability to perform everyday tasks.
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The nervous system is one of the most complicated and enigmatic systems within the animal kingdom.
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The proliferation of single-cell RNA-sequencing data has led to the widespread use of cellular deconvolution, aiding the extraction of cell-type-specific information from extensive bulk data.
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43/100
The impact of apolipoprotein E (ApoE) isoforms on sporadic Alzheimer's disease has long been studied; however, the influences of apolipoprotein E gene (APOE) on healthy and pathological human brains are not fully understood.
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Alzheimer's disease (AD) involves degeneration of cells in the brain.
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The drug development pipeline for a new compound can last 10-20 years and cost over $10 billion.
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Cerebral small vessel disease (cSVDs) account for 25% of stroke and are a frequent cause of cognitive or motor disability in adults.
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β amyloid protein (Aβ)1-42 level from the APOE ε4 carrier group was significantly lower than that from the non-carrier group (p = 0.023), which was associated with worse cognitive function.
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Biological systems are immensely complex, organized into a multi-scale hierarchy of functional units based on tightly regulated interactions between distinct molecules, cells, organs, and organisms.
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Alzheimer's disease (AD) is the most common neurodegenerative disease in the world.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Evaluating Diabetes Drug Targets for Vascular Dementia Prevention Using Drug Target Mendelian Randomisation
- Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia
- Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation
- Altered cell and RNA isoform diversity in aging Down syndrome brains
- ATN Classification and Machine-Learned Plasma Biomarker Phenotypes Reveal Distinct Alzheimer’s Pathology in a Population-Based Cohort
- Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia
- Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer's Disease
- Genome-wide association analysis of secondary imaging phenotypes from the Alzheimer's disease neuroimaging initiative study
- Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology
- Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements