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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 933 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current Alzheimer research 2017 Genetics

    In a cell free assay, ADAM10 activity was found to be significantly lower in apoE4 samples compared to apoE2. 7WCHO cells over expressing wild type AβPP exposed to apoE4 demonstrated reduced formation of sAβPPα compared to other apoE isoforms.

  2. Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2020-01-08 Tau biomarkers

    Alzheimer's disease (AD) displays a long asymptomatic stage before dementia.

  3. Genetics of Alzheimer's disease: where we are, and where we are going

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Current opinion in neurobiology 2019-12-18 Genetics

    Alzheimer's disease (AD) has a very strong genetic component, whose characterization has become an essential part of efforts to understand the pathophysiological processes of the disease.

  4. deepDR: a network-based deep learning approach to in silico drug repositioning

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Bioinformatics (Oxford, England) 2019-12-01 Drug development

    In this study, we developed a network-based deep-learning approach, termed deepDR, for in silico drug repurposing by integrating 10 networks: one drug-disease, one drug-side-effect, one drug-target and seven drug-drug networks.

  5. Towards clinical utility of polygenic risk scores

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Human molecular genetics 2019-11-01 Genetics

    Prediction of disease risk is an essential part of preventative medicine, often guiding clinical management.

  6. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. International review of neurobiology 2019-10-23 Biomarkers

    Multiplex immunoassay conducted on brain lysates showed that alcohol drinking upregulated primary markers of AD pathology in 3xTg-AD mice: Aβ 42/40 ratio in the lateral entorhinal and prefrontal cortex and total Tau expression in the lateral entorhinal cortex, medial prefrontal cortex, and amygdala at 1-month post alcohol exposure.

  7. A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2019-03-01 Genetics

    Alzheimer's disease (AD) is considered a polygenic disorder.

  8. Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Pathology 2018-12-28 Prevention and risk

    Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids, predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to mediate the clearance of their remnants after enzymatic lipolysis in the circulation.

  9. Sex differences in Alzheimer disease - the gateway to precision medicine

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature reviews. Neurology 2018-08-01 Brain scans and imaging

    Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes, risk factors and pathophysiological mechanisms.

  10. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2018-06-21 Risk genes beyond APOE

    Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer's disease (AD) although definitive evidence has not been presented.

  11. Epigenetic Regulation in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Trends in neurosciences 2018-06-07 Genetics

    Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling, and histone post-translational modifications, are involved in multiple aspects of neuronal function and development.

  12. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2018-05-31 Genetics

    The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzheimer's disease (sAD).

  13. Circular RNA and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Advances in experimental medicine and biology 2018-01-01 Brain scans and imaging

    Circular RNAs (circRNAs) represent a special group of noncoding single-stranded highly stable ribonucleic acid entities abundant in the eukaryotic transcriptome.

  14. Untangling Genetic Risk for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biological psychiatry 2017-05-22 Genetics

    Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder caused by fully penetrant single gene mutations in a minority of cases, while the majority of cases are sporadic or show modest familial clustering.

  15. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell 2017-01-19 Genetics

    Human apolipoprotein E (ApoE) apolipoprotein is primarily expressed in three isoforms (ApoE2, ApoE3, and ApoE4) that differ only by two residues.

  16. Genomic variants, genes, and pathways of Alzheimer's disease: An overview

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2017-01-01 Genetics

    Alzheimer's disease (AD) (MIM: 104300) is a highly heritable disease with great complexity in its genetic contributors, and represents the most common form of dementia.

  17. Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Clinical interventions in aging 2016-10-17 Risk genes beyond APOE

    Alzheimer's disease (AD), the most common form of senile dementia, is a genetically complex disorder.

  18. Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Aging and disease 2016-10-01 Risk factors

    Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages.

  19. APOE genotype and stress response - a mini review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Lipids in health and disease 2016-07-25 Genetics

    The APOE gene is one of currently only two genes that have consistently been associated with longevity.

  20. Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of molecular medicine (Berlin, Germany) 2016-06-09 Genetics

    Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease.

  21. HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. NeuroImage 2016-02-23 Digital health tools

    The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus.

  22. A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurobiology of aging 2015-09-25 Tau biomarkers

    Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD).

  23. A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Psychiatric genetics 2015-08 Genetics

    Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.

  24. Corticobasal Syndrome in a Family with Early-Onset Alzheimer's Disease Linked to a Presenilin-1 Gene Mutation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Movement disorders clinical practice 2015-07-25 Risk genes beyond APOE

    Two of three examined members of this family presented with the usual amnestic pattern.

  25. Bioinformatics methods in drug repurposing for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Briefings in bioinformatics 2015-07-21 Drug development

    Alarming epidemiological features of Alzheimer's disease impose curative treatment rather than symptomatic relief.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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