Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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39/100
The past decade has seen the maturation of multiple different forms of high-dimensional molecular profiling to the point that these methods could be deployed in initially hundreds and more recently thousands of human samples.
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Estimated mean survival was 11.6 (10.4-12.9) years and was similar for APP and PSEN1 mutations.
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Genetically predisposition to longer educational attainment and harder math class taken were associated with significantly lower statistical odds ratio of ALS.
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Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer's disease (AD).
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The expression of microRNA (miRNA) is influenced by ongoing biological processes, including aging, and has begun to play a role in the measurement of neurodegenerative processes in central nervous system.
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'Triggering receptor expressed on myeloid cells 2' (TREM2) gene is involved in Alzheimer's disease (AD) and TREM2 mRNA expression is known to be increased in the peripheral blood cells of AD patients.
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A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 (APOE4), is linked to blood-brain barrier breakdown and subsequent cognitive decline.
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The APOE gene alleles modify human aging and the response to the diet at many levels with diverse pleotropic effects from gut to brain.
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In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD).
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction.
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Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane.
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39/100
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently affecting over 5 million Americans with projections expected to rise as the population ages.
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Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment.
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In this regard, this study presents GenEpi, a computational package to uncover epistasis associated with phenotypes by the proposed machine learning approach.
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Alzheimer's disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline.
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The allele ε4 of the apolipoprotein E gene (APOE ε4) is the major genetic risk factor for non-dominantly inherited Alzheimer's Disease (AD).
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Numerous clinical trials of drug candidates for Alzheimer's disease (AD) have failed, and computational drug repositioning approaches using omics data have been proposed as effective alternative approaches to the discovery of drug candidates.
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that mostly strikes the elderly.
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From The Cancer Genome Atlas (TCGA) database, we found 1,643 somatic mutations in the APP, PSEN1, PSEN2, MAPT, SNCA and LRRK2 genes in cancer patients.
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Alzheimer's disease (AD) is the most common form of dementia.
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Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide and may have serious cardiovascular health consequences.
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Episodic memory impairment is the hallmark symptom of Alzheimer's Disease (AD).
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In the present study, a novel mutation in the presenilin 1 gene was discovered in an Iraq-native patient with early-onset Alzheimer's disease, who presented with speech impairment and memory decline at age 46 years.
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Ample evidence suggests that ApoE4 induces microglial dysregulation and impedes Aβ clearance in AD, but the direct neuronal effects of ApoE variants are poorly studied.
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Apolipoprotein E (apoE), a key lipid transport protein in the brain, is predominantly produced by astrocytes.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The epigenetics of aging and neurodegeneration
- Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
- Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimer’s disease
- Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease
- Integrating CSF and EV Proteomes Enhances Biomarker Discovery by Capturing Shared Variation Across Compartments
- Multi-Omics Analysis Reveals Molecular Responses of Alkaloid Content Variations in Lycoris radiata Across Different Locations
- Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies
- The importance of understanding individual differences in Down syndrome
- The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis
- A Deep Learning-Derived Insulin Resistance Index for Cardiovascular Risk Prediction: A Prospective Cohort Study with External Validation in Chinese and US Populations