Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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This represents the largest U.S.-based, multi-site, biomarker initiative of AD in DS.
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We demonstrate that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size.
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We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method.
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The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD.
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69/100
Genetic variants that modify brain gene expression may also influence risk for human diseases.
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This study sets out to identify novel susceptibility genes for late-onset Alzheimer's disease (LOAD) in a powerful set of samples from the UK and USA (1808 LOAD cases and 2062 controls).
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This study analyzed 871 eyes from 439 participants (230 APOE ε4 noncarriers and 209 carriers).
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In addition to the apolipoprotein E (APOE) locus, our GWAS of two independent Chinese samples uncovered three novel AD susceptibility loci (KIAA2013, SLC52A3, and TCN2) and a novel ancestry-specific variant within EGFR (rs1815157).
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The AD PRS model that was most predictive of AD diagnosis (even without APOE) was the liver AD PRS: n = 1,115; odds ratio = 2.15 (1.67-2.78), p = 3.62×10-9.
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It is estimated that the impact of related genes on the risk of Alzheimer's disease (AD) is nearly 70%.
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Dementia is a leading cause of death in many countries.
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The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples.
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The association between PICALM rs3851179 variant and Alzheimer's disease (AD) has been well established by previous genome-wide association studies (GWAS) and candidate gene studies in European population.
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Recently, 19 susceptibility loci for Alzheimer's disease (AD) had been identified through AD genome-wide association studies (GWAS) meta-analysis.
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Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte activation states would shed light on disease processes.
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We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP), which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death.
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We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants.
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We believe that ours is the largest blood biomarker study of preclinical AD to date.
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67/100
We developed a new statistical framework to find genetic variants associated with extreme longevity.
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One hundred and fifty probe-sets form an accurate classifier of young versus older muscle tissue and this healthy ageing RNA classifier performed consistently in independent cohorts of human muscle, skin and brain tissue (n = 594, AUC = 0.83-0.96) and thus represents a biomarker for biological age.
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Overall, our analysis revealed a robustly defined age-related co-methylation module that is present in multiple human tissues, including blood and brain.
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In addition to apolipoprotein E (APOE), recent large genome-wide association studies (GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD).
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APOE -ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis.
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66/100
Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness.
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66/100
Most people's cognitive abilities decline with age, with significant and partly genetically driven, individual differences in rate of change.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- MicroRNAs Related to Cognitive Impairment After Hearing Loss
- Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion
- Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease
- Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology
- Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia
- Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia
- Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
- Integrating Comorbidity Knowledge for Alzheimer's Disease Drug Repurposing using Multi-task Graph Neural Network
- Causal association of cognitive reserve on Alzheimer's disease with putative sex difference
- Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease