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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Apolipoprotein E: far more than a lipid transport protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of genomics and human genetics 2000-01-01 Genetics

    First recognized as a major determinant in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E has emerged as an important molecule in several biological processes not directly related to its lipid transport function, including Alzheimer's disease and cognitive function, immunoregulation, and possibly even infectious diseases.

  2. Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of Human Genetics 1999-07-01 Genetics

    Apolipoprotein E (APOE = gene, apoE = protein) plays a central role in plasma lipoprotein metabolism and in lipid transport within tissues.

  3. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1999-03-01 Drug development

    Mutations in the human presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease.

  4. Apolipoprotein E alleles as risk factors in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of medicine 1996-01-01 Genetics

    Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified.

  5. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of molecular neuroscience : MN 1995-01-01 Down syndrome and Alzheimer's

    Aberrant expression of the amyloid precursor protein (APP) gene may contribute to the beta-amyloid deposition seen in Alzheimer's disease and Down syndrome patients.

  6. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 1994-12-01 Genetics

    Recent evidence indicates that apolipoprotein E (ApoE) plays a central role in the hippocampal response to injury.

  7. Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-30 Risk genes beyond APOE

    This work suggests that although parity history and PSEN2 deficiency exert individual differing age-related effects on cognition and neurobiology, they do not act synergistically.

  8. Integrative systems biology identifies shared neuroimmune co-expression programmes across pulmonary tuberculosis and Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-30 Genetics

    Active PTB was associated with widespread transcriptional remodeling, with 1,389 dysregulated genes organized into 16 PTB-associated co-expression modules.

  9. Joint localization and testing reveals spatial context of differential expression

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-29 Genetics

    Multi-subject spatial transcriptomics is increasingly used to identify molecular differences across individuals and conditions while resolving where in tissue those differences occur.

  10. PIN1-p53 bifurcation dictates opposite cell fate decisions in Alzheimer’s disease and glioblastoma via distinct energy landscape topologies

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-29 Genetics

    Although Alzheimer’s disease (AD) and glioblastoma (GBM) share common aging-related risk factors, they lead to opposite cellular fates—neurodegeneration versus uncontrolled proliferation.

  11. Brain-Derived pTau217 and Plasma Proteomic Profiles Across Cognitive and Dementia Groups in Congolese Older Adults

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-28 Biomarkers

    Blood-based biomarkers for Alzheimer disease and related dementias have been validated largely in populations of European ancestry.

  12. Neuropsychiatric symptom clusters and plasma proteomic signatures across cognitive ageing and dementia in Kinshasa, Democratic Republic of the Congo: a cross-sectional analysis of the EVCD-RDC cohort

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-28 Genetics

    The full cohort included 1044 participants, of whom 779 comprised the proteomics cohort.

  13. Single-Nucleus Profiling Reveals Neuronal Metabolic Collapse During the Transition to Alzheimer’s Disease Dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-28 Genetics

    Current Alzheimer’s disease (AD) neuropathological metrics, including Thal phasing, and Braak staging, often do not accurately predict cognitive status: many cognitively resilient individuals have substantial pathological burdens, whereas some patients with dementia show minimal classical AD pathology.

  14. ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-10-27 Genetics

    Psychosis is a neuropsychiatric feature found across neurodegenerative conditions including Alzheimer’s disease (AD) and Parkinson’s disease (PD).

  15. Proteogenomics captures a midlife biological state of Alzheimer’s disease susceptibility

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-26 Genetics

    Alzheimer’s disease (AD) develops over decades, but biological processes underlying susceptibility during midlife remain poorly understood.

  16. A family-aware All of Us benchmark for polygenic prediction and genomic machine learning

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-26 Genetics

    Polygenic risk scores (PRSs) have improved substantially in predictive performance, yet results remain difficult to compare across studies that differ in cohorts, phenotype definitions, and evaluation procedures.

  17. CausalDiffChem: Causal Network Restoration for Therapeutic Prioritization and Repurposing Across Diseases

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-26 Genetics

    Computational drug repurposing commonly relies on transcriptomic signature matching to identify compounds that reverse disease-associated gene expression, but such approaches do not distinguish putative causal drivers from downstream consequences of disease.

  18. Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-26 Long-term cohort studies

    DNA cytosine modifications play a crucial role in gene regulation that underlies the pathogenesis of complex diseases such as Alzheimer’s disease (AD).

  19. Non-canonical proteoforms of the human fusiform gyrus in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-25 Genetics

    For a long time, the protein coding potential of our genome was underestimated.

  20. Genetic susceptibility to Lewy body disease and the distribution of Lewy pathology

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-24 Genetics

    Across all cases, the SNCA association was indexed by a 5′ signal previously associated with dementia with Lewy bodies and rapid eye movement sleep behaviour disorder, rather than the canonical 3′ Parkinson’s disease variant.

  21. Overcoming segmentation bottlenecks in brain tissue for spatial proteomic inference at population scale

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-24 Genetics

    In spatial proteomics across large cohorts, downstream estimates from tens of thousands of images depend on accurate cell segmentation.

  22. Parental Dementia History is Associated with Peripheral Immune Aging Rather than Generalized Biological and Brain Age Acceleration in Midlife

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-24 Genetics

    Parental history of dementia is a risk factor for Alzheimer’s disease, although the mechanisms underlying this association remain poorly understood.

  23. Associations of genetic predisposition to Alzheimer’s disease with blood-based biomarkers: a community-based study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-23 Biomarkers

    The blood-based biomarker (BBM) profiles associated with genetic susceptibility to Alzheimer’s disease (AD) in general older populations remain poorly understood.

  24. A coordinated and reproducible multicellular response to AD pathology

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-23 Brain tissue and pathology

    While single-cell measurements of the Alzheimer’s disease (AD) brain allow investigation of vulnerable cells in unprecedented depth, reported findings are heterogeneous, mostly descriptive and often ignore interdependence of cellular responses.

  25. Genetic Modifiers of Age at Onset for Parkinson’s Disease in European Populations

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-10-22 Genetics

    This study represents the largest PD AAO meta-analysis in European-ancestry populations to date.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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