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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2021-01-06 Risk genes beyond APOE

    Previous studies showed that U1 small nuclear RNA (snRNA) was selectively enriched in the brain of individuals with familial Alzheimer's disease (AD), resulting in widespread changes in RNA splicing.

  2. Apolipoprotein E (APOE) ε4 Status Moderates the Relationship Between Close-Range Blast Exposure and Cognitive Functioning

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of the International Neuropsychological Society : JINS 2020-11-03 Genetics

    As predicted, we observed a differential impact of CBE status on cognition as a function of APOE ε4 status, in which CBE ε4 carriers displayed significantly worse neuropsychological performance, specifically in the domain of memory.

  3. Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2020-10-21 Tau biomarkers

    Alzheimer's disease (AD) lacks protein biomarkers reflective of its diverse underlying pathophysiology, hindering diagnostic and therapeutic advancements.

  4. MicroRNAs Related to Cognitive Impairment After Hearing Loss

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Clinical and experimental otorhinolaryngology 2020-07-11 Risk factors

    The deaf group showed considerably lower scores on the OPT, OLT, and Y-maze test than the control group.

  5. Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of extracellular vesicles 2020-06-04 Biomarkers

    Alzheimer's disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinical or end-stage disease.

  6. A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain : a journal of neurology 2020-05-01 Genetics

    Aetiological and clinical heterogeneity is increasingly recognized as a common characteristic of Alzheimer's disease and related dementias.

  7. DNA Methylation Biomarkers in Aging and Age-Related Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in genetics 2020-03-10 Genetics

    Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.

  8. The multiplex model of the genetics of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2020-02-28 Genetics

    Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability of 58-79% and early-onset AD showing over 90%.

  9. Expansion of Human-Specific GGC Repeat in Neuronal Intranuclear Inclusion Disease-Related Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. American journal of human genetics 2019-06-06 Genetics

    Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative disease characterized by eosinophilic intranuclear inclusions in the nervous system and multiple visceral organs.

  10. Single-cell transcriptomics unveils gene regulatory network plasticity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Genome biology 2019-06-03 Genetics

    We devise a conceptually different computational framework based on a holistic view, where single-cell datasets are used to infer global, large-scale regulatory networks.

  11. APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019-04-08 Disease mechanisms

    Apolipoprotein E ( APOE ) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD).

  12. The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Lancet. Neurology 2019-02-19 Genetics

    Emerging evidence suggests that these morphological changes reflect functional alterations that affect disease.

  13. Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Social science & medicine (1982) 2018-11-10 Genetics

    Both social and genetic factors contribute to cognitive impairment and decline, yet genetic factors identified through genome-wide association studies (GWAS) explain only a small portion of trait variability.

  14. DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer s Disease 2018-10-22 Biomarkers

    Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer's disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes.

  15. Disease prediction using graph convolutional networks: Application to Autism Spectrum Disorder and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Medical image analysis 2018-06-02 Long-term cohort studies

    Graphs are widely used as a natural framework that captures interactions between individual elements represented as nodes in a graph.

  16. An epigenetic biomarker of aging for lifespan and healthspan

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging 2018-04-01 Disease mechanisms

    Identifying reliable biomarkers of aging is a major goal in geroscience.

  17. Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2018-03-05 Genetics

    Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear.

  18. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Genome medicine 2017-11-29 Biomarkers

    Our results suggest that RAB10 could be a promising therapeutic target for AD prevention.

  19. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2017-09-18 Genetics

    Early expression disturbance of hub genes is an important feature of AD development, and interfering with this process may reverse the disease progression.

  20. A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell systems 2016-12-15 Genetics

    Here, we report proteomic analyses of 129 human cortical tissues to define changes associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD).

  21. Mechanisms linking circadian clocks, sleep, and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 2016-11-01 Risk factors

    Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health.

  22. Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuropathology and experimental neurology 2016-08-11 Genetics

    Apolipoprotein E (apoE) is associated with lipoproteins in the cerebrospinal fluid (CSF).

  23. Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of human genetics : EJHG 2016-05-18 Genetics

    Genome-wide association studies (GWAS) have traditionally been undertaken in homogeneous populations from the same ancestry group.

  24. Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2016-04-27 Risk genes beyond APOE

    The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells.

  25. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2015-05-07 Genetics

    SMC ε4+ showed greater amyloid deposition than SMC ε4-, but no hypometabolism or medial temporal lobe (MTL) atrophy.

From across this topic

9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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