Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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In a multivariate analysis, associations of MS4A6A (rs610932; odds ratio = 0.632, Bonferroni corrected P = .019) and CD33 (rs3865444; odds ratio = 1.492, Bonferroni corrected P = .017) with LOAD were replicated successfully.
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Within this region, we defined a 42-SNP haplotype that was associated with significantly increased risk of ALS (p=7·47×10(-33) when people with familial ALS were compared with controls, odds ratio 21·0, 95% CI 11·2-39·1) and which overlapped with an association locus recently reported for frontotemporal dementia.
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Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder.
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Over the course of an individual’s lifetime, genomic alterations accumulate in somatic cells.
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The APOE4 variant was the strongest genetic risk factor for sporadic Alzheimer's disease (AD).
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Sporadic Alzheimer's disease (sAD) is marked by dysregulated lipid metabolism, prominently involving apolipoprotein E (ApoE).
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Compared to individuals carrying two copies of the ε4 allele of apolipoprotein E (APOE), ε2 homozygotes have an approximate 99% reduction in late-onset Alzheimer's disease (AD) risk.
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Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence.
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Exercise's protective effects in Alzheimer's disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear.
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Hypertension or diabetes before age 62 exerted greater AD risk than APOEε4 alone.
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APOE4-KI mice showed impaired retinal structure, vasculature, function, vision, increased gliosis and neuroinflammation, and downregulation of synaptogenesis.
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The same vulnerable inhibitory neuron subtype was depleted in both AD and DLB.
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The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable factors, with its molecular etiology still unclear.
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46/100
While amyloid precursor protein and the microtubule-associated protein tau demonstrated higher abundance in AD brains, no significant race-related differences were observed.
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Our analysis of common SNVs and indels confirmed known genetic loci at MAPT, MOBP, STX6, SLCO1A2, DUSP10, and SP1, and further uncovered novel signals in APOE, FCHO1/MAP1S, KIF13A, TRIM24, TNXB, and ELOVL1.
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The retina, an anatomical extension of the brain, forms physiological connections with the visual cortex of the brain.
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46/100
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer's disease (AD).
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Alzheimer's Disease (AD) pathology has been increasingly explored through single-cell and single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial transcriptomics (ST).
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We identified sex differences for several classes of metabolites, such as glycerophospholipids, sphingolipids, and amino acids.
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Levels of 24(S)-hydroxycholesterol (24-OHC), 27-hydroxycholesterol (27-OHC), and 24-OHC/27-OHC ratio did not differ by APOE status (p's > 0.05).
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Epidemiological studies reveal a correlation between hearing loss and the development and progression of Alzheimer’s disease (AD), but the underlying causal mechanisms remain unclear.
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Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4.
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The data processing pipelines, research-ready imputed genetic data, and PRS scores are now available on the DPUK platform and can be accessed upon request though the DPUK application process.
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As the population ages, neurodegenerative diseases are becoming more prevalent, making it crucial to comprehend the underlying disease mechanisms and identify biomarkers to allow for early diagnosis and effective screening for clinical trials.
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Some viruses, such as varicella zoster virus, are associated with severe dementia.
From across this topic
10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Investigating the Causal Relationship between Neuroticism and Alzheimer’s Disease Using Mendelian Randomization and the Mediating Role of Modifiable Risk Factors
- Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids
- Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
- Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome
- Towards understanding brain-gut-microbiome connections in Alzheimer's disease
- Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease
- Association of human, rat, and rabbit apolipoprotein E with beta-amyloid
- Droplet-based transcriptome profiling of individual synapses
- Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
- Human longevity: 25 genetic loci associated in 389,166 UK biobank participants