Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in cognitive sciences 2016-03-01 Risk factors

    Research on cognitive aging has focused on how decline in various cortical and hippocampal regions influence cognition.

  2. Brain atrophy in Alzheimer's Disease and aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Ageing research reviews 2016-01-28 Brain scans and imaging

    Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used in clinical routine and research field, largely contributing to our understanding of the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD).

  3. Smartphone for smart living: Using new technologies to cope with everyday limitations in semantic dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychological Rehabilitation 2015-10-19 Cognitive tests and assessment

    New technologies have considerable potential to support people with semantic dementia-a form of progressive aphasia-in their everyday lives, but evidence is still sparse.

  4. MDS research criteria for prodromal Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Movement disorders : official journal of the Movement Disorder Society 2015-10-01 Mild cognitive impairment

    This article describes research criteria and probability methodology for the diagnosis of prodromal PD.

  5. Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Ageing research reviews 2015-08-28 Digital health tools

    Age-related cognitive changes often include difficulties in retrieving memories, particularly those that rely on personal experiences within their temporal and spatial contexts (i.e., episodic memories).

  6. Gait Monitoring for Early Neurological Disorder Detection Using Sensors in a Smartphone: Validation and a Case Study of Parkinsonism

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Telemedicine Journal and e-Health 2015-08-24 Cognitive tests and assessment

    On average, the accuracy of our step length estimation was about 98%.

  7. Altered cortical and subcortical local coherence in PTSD: evidence from resting-state fMRI

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Acta Radiologica 2015-06 Brain scans and imaging

    Compared with the normal controls, PTSD patients showed increased local coherence in subcortical regions, including amygdala, hippocampus, thalamus, and putamen, and decreased local coherence in cortical regions, including medial prefrontal cortex and dorsolateral prefrontal cortex.

  8. Down syndrome: Cognitive and behavioral functioning across the lifespan

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American journal of medical genetics. Part C, Seminars in medical genetics 2015-05-18 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) commonly possess unique neurocognitive and neurobehavioral profiles that emerge within specific developmental periods.

  9. Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2015-05-14 Brain scans and imaging

    Midlife may be an ideal window for intervention in Alzheimer's disease (AD).

  10. Identifying patients with Alzheimer's disease using resting-state fMRI and graph theory

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2015-04-01 Digital health tools

    Classification based on the resting-state fMRI can be used as a non-invasive and automatic tool to diagnosis of Alzheimer's disease.

  11. Levels of Processing in Working Memory: Differential Involvement of Frontotemporal Networks

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Cognitive Neuroscience 2015-03-01 Lewy body dementia

    How does the brain maintain to-be-remembered information in working memory (WM), particularly when the focus of attention is drawn to processing other information?

  12. The psychological and neurocognitive consequences of critical illness. A pragmatic review of current evidence

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the Intensive Care Society 2015-01-26 Clinical safety

    Mortality rates alone are no longer a sufficient guide to quality of care.

  13. Sleep-related behaviors in Alzheimer’s disease and dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Reviews in the Neurosciences 2015-01-01 Risk factors

    Prevalence studies suggest that Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly.

  14. Sleep, Cognition, and Normal Aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Perspectives on Psychological Science 2015-01 Risk factors

    Sleep is implicated in cognitive functioning in young adults.

  15. White Matter Microstructural Damage in Small Vessel Disease Is Associated With Montreal Cognitive Assessment But Not With Mini Mental State Examination Performances

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Stroke 2015-01 Cognitive tests and assessment

    MoCA is suited for the cognitive screening of patients with small vessel disease.

  16. Anosognosia in Alzheimer's disease: diagnosis, frequency, mechanism and clinical correlates

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cortex; a journal devoted to the study of the nervous system and behavior 2014-12-01 Caregiving

    Anosognosia is present in a large proportion of patients with mild Alzheimer's disease (AD), and its frequency increases with the progression of the illness.

  17. Multimodal neuroimaging feature learning for multiclass diagnosis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. IEEE transactions on bio-medical engineering 2014-11-20 Digital health tools

    The accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and will be increasingly important as disease modifying agents become available, early in the course of the disease.

  18. Functional connectivity dynamics: modeling the switching behavior of the resting state

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2014-11-10 Brain scans and imaging

    Functional connectivity (FC) sheds light on the interactions between different brain regions.

  19. Machine learning framework for early MRI-based Alzheimer's conversion prediction in MCI subjects

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2014-10-12 Digital health tools

    Mild cognitive impairment (MCI) is a transitional stage between age-related cognitive decline and Alzheimer's disease (AD).

  20. Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2014-09-29 Brain scans and imaging

    Brain stimulation, a therapy increasingly used for neurological and psychiatric disease, traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and noninvasive approaches, such as transcranial magnetic stimulation.

  21. Pain and decreased cognitive function negatively impact physical functioning in older adults with knee osteoarthritis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pain medicine (Malden, Mass.) 2014-07-08 Cognitive tests and assessment

    Worse pain scores and executive function scores were associated with worse physical function in older adults with painful knee OA.

  22. Sleep and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Sleep medicine reviews 2014-04-03 Risk factors

    Sleep disorders are frequent in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization.

  23. Alzheimer's disease in African Americans: risk factors and challenges for the future

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Health affairs (Project Hope) 2014-04-01 Disparities

    As the US elderly population continues to expand rapidly, Alzheimer's disease poses a major and increasing public health challenge, and older African Americans may be disproportionately burdened by the disease.

  24. Functional brain connectivity using fMRI in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychology review 2014-02-23 Brain scans and imaging

    Normal aging and Alzheimer's disease (AD) cause profound changes in the brain's structure and function.

  25. What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2014-02-16 Brain scans and imaging

    What can be expected in normal aging, and where does normal aging stop and pathological neurodegeneration begin?

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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