alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topic

Brain imaging, connectivity and assessment

1,533 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Overlapping Phenotypes and Associations

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-09-14 Risk factors

    Traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), and Alzheimer's disease (AD) share several neuropathophysiological mechanisms, including axonal injury, neuroinflammation, and abnormal protein aggregation, which may contribute to overlapping clinical manifestations.

  2. Hybrid Computational-Human Synthesis of the Human Connectome Project: Network Stability, Lifespan Reorganization and Biomarker Potential

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-09-14 Risk factors

    Launched in 2010 by the National Institutes of Health, the Human Connectome Project (HCP) represents a foundational initiative in systems neuroscience, designed to map the structural and functional architecture of the human brain.

  3. Exercise effects on balance confidence and concerns about falling in older adults with cognitive impairment: a construct-stratified meta-analysis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-14 Mild cognitive impairment

    Older adults with mild cognitive impairment (MCI) or dementia have elevated fall risk, but fall-related psychological outcomes represent distinct constructs that should not be pooled indiscriminately.

  4. Vocal acoustic biomarkers predict amyloid positivity in non-demented individuals

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-11 Digital health tools

    Amyloid-β deposition begins in the earliest preclinical stages of Alzheimer's disease, long before cognitive decline is detectable by standard clinical assessments, which are often limited by ceiling effects and create a need for non-invasive, scalable markers.

  5. Gender bias in the diagnosis of Alzheimer's Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-11 Mild cognitive impairment

    Fairness in clinical machine-learning (ML) remains a critical challenge, particularly in neurodegenerative disease where demographic factors may confound disease-related patterns.

  6. Hypertension is associated with better brain health outcomes in older-age asymptomatic carotid disease populations - A Multi-Cohort Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Risk factors

    Hypertension is associated with lower risk of dementia-related outcomes in aECAD patients.

  7. Coronary artery disease and neurocognitive performance among older adults in Uganda

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Risk factors

    CAD was not associated with global or domain-level neurocognitive performance.

  8. Brain Iron Accumulation and Its Cognitive and Olfactory Correlates in Late-Life Depression

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Risk factors

    Late-life depression (LLD) is associated with cognitive impairment, olfactory dysfunction and dementia risk, while brain iron accumulation has been linked to depressive symptoms, cognitive impairment and Alzheimer’s disease progression.

  9. nterpretable Alzheimer’s Disease Detection from CHAT Transcripts Using Criterion-Guided LLM Prompting and In-Context Learning

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Digital health tools

    Early detection of Alzheimer’s disease (AD) from spontaneous speech remains a clinically significant challenge.

  10. Digital motor and cognitive variability as early markers of the prodromal Parkinson’s disease spectrum

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-09-10 Mild cognitive impairment

    Performance variability precedes measurable linear decline across PD-risk stratified groups.

  11. Comparative Analysis of Individual Graph Construction Methods from Static FDG-PET Images: an ADNI study in Alzheimer’s Disease Subjects

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Mild cognitive impairment

    Our findings indicate that all methods captured AD disconnection patterns but exhibited variability in preserving connectivity profiles, which seemed non-random but rather systematically linked to clinical measures and predictive power for AD classification.

  12. Stage-dependent indirect association between mobility and the cognition-ADL relationship: a cross-sectional study of older adults across the cognitive continuum

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-10 Mild cognitive impairment

    In this cross-sectional sample, mobility showed a progressively stronger statistical indirect association with the cognition-ADL relationship as cognitive impairment deepened.

  13. Universal Dimensional Scaling in Information-Geometric Rendering: Substrate-Independent Metric Conservation Across Holographic, Biological, and Engineered Manifolds

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-09-09 Brain scans and imaging

    In the primary visual cortex (V1), we show that cortical magnification (M) is a deterministic Riemannian coordinate transformation (M \propto 1/\sqrt{\det g}) that equalizes information pressure between the spherical retina and planar cortex.2.

  14. Association Between Combined Multiple Behaviors and Cognitive Impairment in Older Adults: A 10-Year Cohort Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-09-09 Risk factors

    Of total 8,321 participants, 24.88% (2,070) developed cognitive impairment during a 10-year follow-up.

  15. Comparative comorbidity burden in hospitalized primary Parkinson's disease and secondary parkinsonism: a cross-sectional study from Southwest China

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-09 Risk factors

    The study evaluated 1,457 PD patients (1,050 primary; 407 secondary) alongside 2,100 matched non-PD controls.

  16. How Reliable and Explainable Are Machine Learning Models for Dementia Detection? A Leakage-Aware Evaluation

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-09 Cognitive tests and assessment

    Reported dementia-classification performance depends on how the label is defined, which clinical information the model sees, and whether participants are separated between training and test data.

  17. Specification dependence of EEG theta/alpha ratio associations with cognitive impairment: a multiverse analysis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-08 Lewy body dementia

    The theta/alpha ratio is a promising but specification-dependent marker of cognitive impairment, contingent particularly on ICA and spectral power quantification.

  18. A 2-Level Stacking Ensemble Framework for Multi-Class Alzheimer’s Disease Diagnosis Using CNN Feature Extractors and SVM-XGBoost Classifiers

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-07 Long-term cohort studies

    Alzheimer's disease classification by means of Magnetic Resonance Imaging demands strong models that are able to generalise to different stages of dementia.

  19. Face Processing Impairments in Dementia Syndromes: A Systematic Review

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-09-06 Lewy body dementia

    Face processing abilities are critical for social interaction, yet impairments are common across dementia syndromes and constitute a core diagnostic feature of some neurocognitive disorders.

  20. Dyadic self- and informant-reported cognitive concern and subsequent MCI/AD diagnosis in ADNI: an exploratory prognostic modelling study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-04 Caregiving

    M2 C-index 0.682, M3 0.692, M4 0.687. Adding the dyadic mean yielded an estimated ΔC of 0.010 (95% CI -0.003 to 0.024).

  21. Repetitive negative thinking moderates the association between self-referential thoughts and cognition amongst older adults: a natural speech analysis approach

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-04 Digital health tools

    Natural language processing has been examined as a possible biomarker for cognitive decline and dementia, but it has also been associated with components of well-being and psychological distress.

  22. Alzheimer disease risk estimates lose clinical calibration across study phases despite useful patient ranking

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-04 Long-term cohort studies

    Risk prediction in Alzheimer disease can guide follow-up, biomarker testing, trial referral, and prognostic counseling.

  23. Alzheimer's Disease Detection via Large Pre-Trained Speech and Language Models: Taxonomy, Progress, and Open Challenges

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-09-03 Digital health tools

    Alzheimer's Disease (AD) detection from spoken language has advanced considerably with the rise of large pre-trained speech and language models, including wav2vec 2.0, BERT, generative LLMs, and emerging audio-LLMs.

  24. Insomnia symptoms, daytime sleepiness, and quality of life in people with Alzheimer’s disease: a secondary cross-sectional analysis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-02 Risk factors

    Participants were aged 60–94 years, with a mean age of 78.5 ± 7.9 years, and 45.7% were women.

  25. A Study on the Association Between the Course of Heart Failure and Cognitive Function in Older Adults: Based on Data from the 2011–2014 National Health and Nutrition Examination Survey

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-02 Prevention and risk

    The 2,885 participants had a mean age of 69.5 years.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

Other topics