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You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Activity Engagement and Cognitive Performance Amongst Older Adults

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in psychology 2021-03-11 Risk factors

    Research supporting cognitive reserve theory suggests that engaging in a variety of cognitive, social, and physical activities may serve as protective factors against age-related changes in mental functioning, especially if the activities are cognitively engaging.

  2. Sleep in the Aging Brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain sciences 2021-02-12 Risk factors

    We have entered an era of a steep increase in the absolute and relative number of older people.

  3. Bilingualism's Effects on Resting-State Functional Connectivity in Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain connectivity 2021-01-21 Brain scans and imaging

    We found no significant differences between the groups in age, sex, education, or cognitive level, but bilinguals showed higher FC than monolinguals between the posterior part of the superior temporal gyrus and the precuneus, positively correlated with Mini-Mental State Examination scores, and higher fALFF in the thalamus bilaterally.

  4. Crosstalk between Depression and Dementia with Resting-State fMRI Studies and Its Relationship with Cognitive Functioning

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomedicines 2021-01-16 Risk factors

    Alzheimer's disease (AD) is the most common type of dementia, and depression is a risk factor for developing AD.

  5. Computerized cognitive stimulation for people with dementia or with mild cognitive impairment: a bibliometric review

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Dementia & neuropsychologia 2021 Cognitive tests and assessment

    The data show that dementia research is exponentially developing following the evolution of widespread use of computer science.

  6. Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current topics in behavioral neurosciences 2021 Risk factors

    Evidence from epidemiological studies on the general population suggests that midlife cardiovascular disease (CVD) and/or metabolic syndrome (MetS) are associated with an increased risk of cognitive impairment and dementia later in life.

  7. Cost of Illness of Major Neurocognitive Disorders in India

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurology India 2021 Costs and economics

    The annual cost of care per patient with mild to moderate and severe major MCD was INR 78288 and INR 167808, respectively.

  8. Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage. Clinical 2020-12-16 Risk factors

    Compared to healthy controls, patients with FTD showed glucose hypometabolism in bilateral frontal and temporal brain areas whereas cognition was only associated with deteriorated glucose metabolism in the left temporal lobe.

  9. Cognitive reserve relates to executive functioning in the old-old

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging clinical and experimental research 2020-12-06 Risk factors

    Cognitive reserve (CR) is known to reduce or even protect against the negative effects of aging on cognitive functioning.

  10. Hi-GCN: A hierarchical graph convolution network for graph embedding learning of brain network and brain disorders prediction

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Computers in biology and medicine 2020-11-03 Digital health tools

    The proposed hi-GCN method performs the graph embedding learning from a hierarchical perspective while considering the structure in individual brain network and the subject's correlation in the global population network, which can capture the most essential embedding features to improve the classification performance of disease diagnosis.

  11. High-resolution functional connectivity of the default mode network in young adults with down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain imaging and behavior 2020-10-18 Brain scans and imaging

    Studies of resting-state functional connectivity MRI in Alzheimer's disease suggest that disease stage plays a role in functional changes of the default mode network.

  12. Detection of Mild Cognitive Impairment Through Natural Language and Touchscreen Typing Processing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in digital health 2020-10-08 Cognitive tests and assessment

    Mild cognitive impairment (MCI), an identified prodromal stage of Alzheimer's Disease (AD), often evades detection in the early stages of the condition, when existing diagnostic methods are employed in the clinical setting.

  13. Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of geriatric psychiatry and neurology 2020-10-08 Brain scans and imaging

    Apathy severity was significantly associated with cortical thinning of the lateral parts of the right sided frontal, temporal and parietal lobes.

  14. Supervised Digital Neuropsychological Tests for Cognitive Decline in Older Adults: Usability and Clinical Validity Study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. JMIR mHealth and uHealth 2020-09-21 Cognitive tests and assessment

    The positive results pave the way for the deployment of the system to a nonsupervised environment, thus representing a potential efficacious and ecological solution to support clinicians in the identification of early signs of cognitive decline.

  15. A Comprehensive Evaluation of the Process of Copying a Complex Figure in Early- and Late-Onset Alzheimer Disease: A Quantitative Analysis of Digital Pen Data

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of medical Internet research 2020-08-12 Cognitive tests and assessment

    The digitalized complex figure test evaluated copying performance quantitatively and further elucidated the patients' ongoing process during copying.

  16. Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain : a journal of neurology 2020-06-01 Biomarkers

    BvFTD shows significant symptomatic overlap with non-degenerative primary psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders.

  17. Early Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2020-05-13 Digital health tools

    The result revealed an accuracy rate of 0.84 ± 0.05, 0.79 ± 0.04, and 0.62 ± 0.06, respectively, for classifying AD vs. These results suggest that as a data-driven method, the combined CNN and EL approach can locate the most discriminable brain regions indicated by the trained ensemble model while the generalization ability of the ensemble model was maximized to successfully capture AD-related brain variations early in the disease process; it can also provide new insights into understanding the complex heterogeneity of whole-brain MRI changes in AD.

  18. The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG)

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of clinical medicine 2020-05-06 Cognitive tests and assessment

    Due to the lack of pharmacological treatment for dementia, timely detection of subjects at risk can be of seminal importance for preemptive rehabilitation interventions.

  19. Bias-adjustment in neuroimaging-based brain age frameworks: A robust scheme

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage. Clinical 2019-11-04 Digital health tools

    The level of prediction error in the brain age estimation frameworks is associated with the authenticity of statistical inference on the basis of regression models.

  20. Layer-Wise Relevance Propagation for Explaining Deep Neural Network Decisions in MRI-Based Alzheimer's Disease Classification

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2019-07-31 Digital health tools

    Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer's disease (AD) detection based on structural magnetic resonance imaging (MRI) data.

  21. Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. BMJ open 2019-03-23 Cognitive tests and assessment

    Recent failures of potential novel therapeutics for Alzheimer's disease (AD) have prompted a drive towards clinical studies in prodromal or preclinical states.

  22. A Review on a Deep Learning Perspective in Brain Cancer Classification

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cancers 2019-01-18 Digital health tools

    A World Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent.

  23. A Smartphone Application for Automated Decision Support in Cognitive Task Based Evaluation of Central Nervous System Motor Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. IEEE Journal of Biomedical and Health Informatics 2019-01-09 Cognitive tests and assessment

    The system uses a collected dataset of 1928 records, taken from 11 HD patients and 11 healthy persons in Lithuania, to gather statistics about examinations and presents the results as medical evaluation with prediction on the state of health.

  24. Hierarchical Fully Convolutional Network for Joint Atrophy Localization and Alzheimer's Disease Diagnosis Using Structural MRI

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. IEEE transactions on pattern analysis and machine intelligence 2018-12-21 Digital health tools

    Structural magnetic resonance imaging (sMRI) has been widely used for computer-aided diagnosis of neurodegenerative disorders, e.g., Alzheimer's disease (AD), due to its sensitivity to morphological changes caused by brain atrophy.

  25. Structural neuroimaging as clinical predictor: A review of machine learning applications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage. Clinical 2018-08-10 Digital health tools

    In this paper, we provide an extensive overview of machine learning techniques applied to structural magnetic resonance imaging (MRI) data to obtain clinical classifiers.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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