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Behavioral disorders in the frontal and temporal variants of frontotemporal dementia
W. Liu, Bruce L. Miller, Joel H. Kramer, Katherine P. Rankin, Christina Wyss-Coray, Rosalie Gearhart, La Phengrasamy, Michael Walter Weiner et al.. Neurology, 2004-03-09
Topic: Brain imaging, connectivity and assessment
Both variants of FTD showed significant increases in rates of elation, disinhibition, and aberrant motor behavior compared with AD. The fvFTD group also showed more anxiety, apathy, and eating disorders, and tvFTD showed a higher prevalence of sleep disturbances than AD. The only behaviors that differed significantly between fvFTD and tvFTD were apathy, greater in fvFTD, and sleep disorders, more frequent in tvFTD. FvFTD was associated with greater frontal atrophy and tvFTD was associated with more temporal and amygdala atrophy compared with AD, but both groups showed significant atrophy in the VMFC compared with AD, which was not associated with VMFC atrophy. In FTD, the presence of many of the behavioral disorders was associated with decreased volume in right-hemispheric regions. FvFTD and tvFTD show many similarities in behavior, which appear to be associated with damage to right frontal and temporal structures.
Key findings
- Both variants of FTD showed significant increases in rates of elation, disinhibition, and aberrant motor behavior compared with AD.
- The fvFTD group also showed more anxiety, apathy, and eating disorders, and tvFTD showed a higher prevalence of sleep disturbances than AD.
- The only behaviors that differed significantly between fvFTD and tvFTD were apathy, greater in fvFTD, and sleep disorders, more frequent in tvFTD.
- FvFTD was associated with greater frontal atrophy and tvFTD was associated with more temporal and amygdala atrophy compared with AD, but both groups showed significant atrophy in the VMFC compared with AD, which was not associated with VMFC atrophy.
- In FTD, the presence of many of the behavioral disorders was associated with decreased volume in right-hemispheric regions.
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Study details
- Participants51
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 29 of the 58 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 1 / 4 | 51 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15007124) |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 58 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Liu, W., Miller, B. L., Kramer, J. H., Rankin, K. P., Wyss-Coray, C., Gearhart, R., et al. (2004). Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology. https://doi.org/10.1212/01.wnl.0000113729.77161.c9
Vancouver
Liu W, Miller BL, Kramer JH, Rankin KP, Wyss-Coray C, Gearhart R, et al. Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology. 2004. doi:10.1212/01.wnl.0000113729.77161.c9. PMID: 15007124.
BibTeX
@article{liu2004-15007124,
author = {Liu, W. and Miller, Bruce L. and Kramer, Joel H. and Rankin, Katherine P. and Wyss-Coray, Christina and Gearhart, Rosalie and Phengrasamy, La and Weiner, Michael Walter and others},
title = {{Behavioral disorders in the frontal and temporal variants of frontotemporal dementia}},
journal = {Neurology},
year = {2004},
doi = {10.1212/01.wnl.0000113729.77161.c9},
pmid = {15007124},
url = {https://doi.org/10.1212/01.wnl.0000113729.77161.c9}
}
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