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Brain tissue volumes in relation to cognitive function and risk of dementia
Ikram MA, Vrooman HA, Vernooij MW, den Heijer T, Hofman A, Niessen WJ, van der Lugt A, Koudstaal PJ et al.. Neurobiology of aging, 2008-05-23
Topic: Risk, prevention and care in population studies
We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia. Participants (n=490; 60-90 years) were non-demented at baseline (1995-1996). From baseline brain MRI-scans we obtained global and lobar volumes of CSF, GM, normal WM, white matter lesions and hippocampus. We performed neuropsychological testing at baseline to assess information processing speed, executive function, memory function and global cognitive function. Participants were followed for incident dementia until January 1, 2005. Larger volumes of CSF and WML were associated with worse performance on all neuropsychological tests, and an increased risk of dementia. Smaller WM volume was related to poorer information processing speed and executive function. In contrast, smaller GM volume was associated with worse memory function and increased risk of dementia. When investigating lobar GM volumes, we found that hippocampal volume and temporal GM volume were most strongly associated with risk of dementia, even in persons without objective and subjective cognitive deficits at baseline, followed by frontal and parietal GM volumes.
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APA 7th
Ikram, M. A., Vrooman, H. A., Vernooij, M. W., den Heijer, T., Hofman, A., Niessen, W. J., et al. (2010). Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2008.04.008
Vancouver
Ikram MA, Vrooman HA, Vernooij MW, den Heijer T, Hofman A, Niessen WJ, et al. Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of aging. 2010. doi:10.1016/j.neurobiolaging.2008.04.008. PMID: 18501994.
BibTeX
@article{ikram2010-18501994,
author = {Ikram, M. A. and Vrooman, H. A. and Vernooij, M. W. and den Heijer, T. and Hofman, A. and Niessen, W. J. and van der Lugt, A. and Koudstaal, P. J. and others},
title = {{Brain tissue volumes in relation to cognitive function and risk of dementia}},
journal = {Neurobiology of aging},
year = {2010},
doi = {10.1016/j.neurobiolaging.2008.04.008},
pmid = {18501994},
url = {https://doi.org/10.1016/j.neurobiolaging.2008.04.008}
}
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Key findings
- Larger volumes of CSF and WML were associated with worse performance on all neuropsychological tests, and an increased risk of dementia.
- In contrast, smaller GM volume was associated with worse memory function and increased risk of dementia.
- When investigating lobar GM volumes, we found that hippocampal volume and temporal GM volume were most strongly associated with risk of dementia, even in persons without objective and subjective cognitive deficits at baseline, followed by frontal and parietal GM volumes.
Study details
- Study designcohort study
- Participants490
- Evidence strengthModerate
How this study scored 60/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 35 of the 58 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 490 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18501994) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 35 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 35 of the 58 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
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