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Preeclampsia and eclampsia: the conceptual evolution of a syndrome
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F.. American journal of obstetrics and gynecology, 2022-02-01
Topic: Risk, prevention and care in population studies
We review the epidemiologic data that led to the recommendation to use diastolic hypertension and proteinuria as diagnostic criteria, as their combined presence was associated with an increased risk of fetal death and the birth of small-for-gestational-age neonates. The search for putative toxins has challenged investigators for more than a century, and a growing body of evidence suggests that products of an ischemic or a stressed placenta are responsible for the vascular changes that characterize this syndrome. Early-onset preeclampsia has many features in common with atherosclerosis, whereas late-onset preeclampsia seems to result from a mismatch of fetal demands and maternal supply, that is, a metabolic crisis. However, these adverse events may be the result of a preexisting vascular pathologic process; it is not known if the occurrence of preeclampsia increases the baseline risk.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Erez, O., Romero, R., Jung, E., Chaemsaithong, P., Bosco, M., Suksai, M., et al. (2022). Preeclampsia and eclampsia: the conceptual evolution of a syndrome. American journal of obstetrics and gynecology. https://doi.org/10.1016/j.ajog.2021.12.001
Vancouver
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, et al. Preeclampsia and eclampsia: the conceptual evolution of a syndrome. American journal of obstetrics and gynecology. 2022. doi:10.1016/j.ajog.2021.12.001. PMID: 35177220.
BibTeX
@article{erez2022-35177220,
author = {Erez, O. and Romero, R. and Jung, E. and Chaemsaithong, P. and Bosco, M. and Suksai, M. and Gallo, D. M. and Gotsch, F.},
title = {{Preeclampsia and eclampsia: the conceptual evolution of a syndrome}},
journal = {American journal of obstetrics and gynecology},
year = {2022},
doi = {10.1016/j.ajog.2021.12.001},
pmid = {35177220},
url = {https://doi.org/10.1016/j.ajog.2021.12.001}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- We review the epidemiologic data that led to the recommendation to use diastolic hypertension and proteinuria as diagnostic criteria, as their combined presence was associated with an increased risk of fetal death and the birth of small-for-gestational-age neonates.
- The search for putative toxins has challenged investigators for more than a century, and a growing body of evidence suggests that products of an ischemic or a stressed placenta are responsible for the vascular changes that characterize this syndrome.
- Early-onset preeclampsia has many features in common with atherosclerosis, whereas late-onset preeclampsia seems to result from a mismatch of fetal demands and maternal supply, that is, a metabolic crisis.
- However, these adverse events may be the result of a preexisting vascular pathologic process; it is not known if the occurrence of preeclampsia increases the baseline risk.
Why it matters
This review does not report any test of a treatment, cure, or prevention for Alzheimer's disease. It only discusses ideas about the causes of preeclampsia and eclampsia and notes that it is not known whether preeclampsia increases baseline risk.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of obstetrics and gynecology) |
| Journal's citation record | 3 / 4 | American Journal of Obstetrics and Gynecology: journal h-index 383 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 282 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 47.0 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 6 / 6 | Cited 51.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 191 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Francesca Gotsch: h-index 63 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 11 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35177220) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.ajog.2021.12.001
- PubMed: 35177220
- Original source →
- Free full text: American Journal of Obstetrics and Gynecology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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